Exploration of adjuvant for optimization of transcutaneous vaccine
Project/Area Number |
25670076
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | ワクチン / アジュバント / マイクロニードル |
Outline of Final Research Achievements |
We have developed a dissolving microneedle array for use as a transcutaneous vaccination (TCV) device, and reported that TCV with the dissolving microneedle array induced an immune response against antigens as well as systemic injection. In this study, I searched for the adjuvant which aimed at optimization of TCV. As a result, Monophosphoryl Lipid A (MPLA) and ODN1826 enhanced antibody production against ovalbumin as a model antigen on TCV used dissolving microneedle. ODN1826 and MPLA will be useful as TCV adjuvant.
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Report
(3 results)
Research Products
(22 results)
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[Presentation] 貼るワクチンについて2015
Author(s)
中川晋作
Organizer
日本薬学会第135年会 市民公開講座
Place of Presentation
大阪(大阪大学中之島センター)
Year and Date
2015-03-29
Related Report
Invited
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