| Project/Area Number |
25670082
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Showa Pharmaceutical University |
|---|
Principal Investigator |
KOIZUMI Naoya 昭和薬科大学, 薬学部, 講師 (80433845)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | ターゲティング / がん / タンパク質医薬品 / ＤＤＳ / 組織深部 / タンパクデリバリー |
|---|
| Outline of Final Research Achievements |
As the cancer tissue is increased, medicine is less likely to reach the central portion of the cancer tissue. In particular, protein pharmaceuticals having a relatively large molecular weight, low arrival rate to the central portion of the cancerous tissue as its size, which decrease therapeutic effect. Therefore, the present study was conducted to develop a new technology to transport efficiently therapeutic protein in deep (center portion) of cancer tissue. As a result, a therapeutic protein using the viral proteins successfully be delivered to deep of cancer tissue. However, from the fact that you've been delivered also to normal tissue as well as cancer tissue, the grant of the only transport available functions in cancer tissue was cited as future challenges.
|
