a mechanism underlying microglial activation by chronic stress
| Project/Area Number |
25670093
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Nagoya University |
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Principal Investigator |
KIYAMA Hiroshi 名古屋大学, 医学(系)研究科(研究院), 教授 (00192021)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ミクログリア / 疼痛 / 慢性疲労 / 線維筋痛症 / 慢性ストレス |
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| Outline of Final Research Achievements |
Patients with fibromyalgia (FM) and chronic fatigue syndrome (CFS) suffer from chronic pain and severe fatigue. To analyze molecular mechanisms underlying the pain, we employed CFS and FM animal models. We found significant accumulation and activation of microglia in the lumber level of dorsal horn of spinal cord, although no inflammatory and injurious incidents were observed in peripheral tissues and peripheral blood. Minocycline treatment suppressed both microglial activation and pain behavior in CFS animal model. Further analysis on dorsal root ganglia and anti-gravity muscle suggests that a chronic hyper-activation of proprioceptor may activate microglia in the dorsal horn, and the locally activated microglia may be associated with the abnormal pain.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents2014
Author(s)
Akagi T, Matsumura Y, Yasui M, Minami E, Inoue H, Masuda T, Tozaki-Saitoh H, Tamura T, Mizumura K, Tsuda M, Kiyama H, Inoue K
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Journal Title
Journal of Pharmacological Sciences
Volume: 126
Issue: 2
Pages: 172-176
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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