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Molecular role for Geminin in maintaining cardiac muscles

Research Project

Project/Area Number 25670096
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General anatomy (including histology/embryology)
Research InstitutionHiroshima University

Principal Investigator

TAKIHARA Yoshihiro  広島大学, 原爆放射線医科学研究所, 教授 (60226967)

Co-Investigator(Kenkyū-buntansha) YASUNAGA Shin'ichiro  広島大学, 原爆放射線医科学研究所, 准教授 (50336111)
OHNO Yoshinori  広島大学, 原爆放射線医科学研究所, 助教 (10548986)
SHIRAI Manabu  独立行政法人国立循環器病研究センター, 研究所, 室長 (70294121)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsポリコーム遺伝子群 / Geminin / 心筋 / 心臓発生 / 心筋維持 / 維持 / ポリコーム複合体1
Outline of Final Research Achievements

Polycomb-group of (PcG) genes maintain expression of Nkx2.5 gene, a developmental regulator for cardiac development and further act as an E3 ubiquitin ligase for Geminin. On the other hand, overexpression of Rae28 and Pcgf5 deficiency gave rise to dilated cardiomyopathy. Thus, PcG genes are not only involved in cardiac development but also in maintenance of cardiac muscle. We visualized a Geminin molecule by generating Geminin-EYFP knock-in mice. Curiously, we identified cardiac muscles with high Geminin expression in the adult, indicating that these are corresponding with cycling cardiac muscles or cardiac stem cells.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] Transcription of the Geminin gene is regulated by a negative-feedback loop.2014

    • Author(s)
      Ohno, Y., Saeki, K., Yasunaga, S., Kurogi. T., Suzuki-Takedachi, K., Shirai, M., Mihara K., Yoshida, K., Voncken J. W, Ohtsubo, M. & Takihara Y.
    • Journal Title

      Mol. Biol. Cel

      Volume: 25(8) Issue: 8 Pages: 1374-1383

    • DOI

      10.1091/mbc.e13-09-0534

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Functional roles of Polycomb Ring Finger 5 (Pcgf5) in the heart of adult mice.2014

    • Author(s)
      Shirai, M., Otani, K., Tsuchimochi, H., Takihara, Y., Morisaki, T.
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Molecular role for Geminin in governing hematopoietic stem cell activity2014

    • Author(s)
      Takihara, Y.
    • Organizer
      Views into nuclear function: A See Drug Workshop
    • Place of Presentation
      Patras, Greece
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Functional analysis of Pcgf5 (Polycomb ring finger 5) in developing heart2013

    • Author(s)
      Shirai, M.
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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