Circulation physiology of continuous flow with artificial heart

• Project/Area Number: 25670105
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: The University of Tokyo
• Principal Investigator: INOUE Yusuke 東京大学, 工学(系)研究科(研究院), 研究員 (80611079)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 微小循環 / 循環生理学 / 末梢循環 / 循環調節 / 顕微鏡 / 体内埋込 / 人工心臓 / 駆動方式 / 生体内観察 / 血管新生 / 組織工学 / 足場 / 拍動流

Outline of Final Research Achievements

We developed microscope for micro circulation. We developed 3 type devices. The observation microscope has scaffold for angiogenesis. The PGA fabric and polyester fabric was used as scaffolds. And we get stable data with this device. We experiment with Total Artificial Heart. The animal with artificial heart living, and we observed our observation device. We change the heart drive pattern, exercise stress test, dose a medicine. We analyze the data. We found the difference of flow in the micro circulation via pattern of artificial heart moving.

Research Products

• [Journal Article] Hydrodynamic characteristics of the helical flow pump (2015)
  • Author(s): Ishii K, Hosoda K, Nishida M, Isoyama T, Saito I, Ariyoshi K, Inoue Y, Ono T, Nakagawa H, Sato M, Hara S, Lee X, Wu S, Imachi K, Abe Y
  • Journal Title: J Artif Organs Volume: 18 Issue: 3 Pages: 206-212
  • DOI: 10.1007/s10047-015-0828-y
  • Peer Reviewed
• [Journal Article] Concept of left atrial pressure estimation using its pulsatile amplitude in the helical flow total artificial heart (2014)
  • Author(s): Wu S, Saito I, Isoyama T, Inoue Y, Sato M, Hara S, Li X, Yurimoto T, Murakami H, Kawase K, Ono T, Abe Y
  • Journal Title: J Artif Organs Volume: 17 Issue: 4 Pages: 301-307
  • DOI: 10.1007/s10047-014-0788-7
  • Peer Reviewed
• [Journal Article] Computational fluid dynamics analysis of the pump parameters in the helical flow pump (2014)
  • Author(s): Hosoda K, Ishii K, Isoyama T, Saito I, Inoue Y, Ariyoshi K, Ono T, Nakagawa H, Imachi K, Kumagai H, Abe Y
  • Journal Title: J Artif Organs Volume: 17 Issue: 1 Pages: 9-15
  • DOI: 10.1007/s10047-013-0739-8
  • Peer Reviewed
• [Journal Article] The helical flow total artificial heart: implantation in goats (2013)
  • Author(s): Abe Y
  • Journal Title: Proc 35th Ann Intern Conf IEEE EMBS Volume: なし Pages: 2720-2723
  • Peer Reviewed
• [Presentation] 次世代完全人工心臓の実用化を目指して：螺旋流完全人工心臓の開発 (2015)
  • Author(s): 阿部裕輔、磯山隆、斎藤逸郎、原伸太郎、佐藤雅巳、圦本晃海、李欣陽、村上遥、小野俊哉、川瀬由季乃、前野映里奈、田代彩夏、井上雄介、深沢今日子、石原一彦、高井まどか、小野稔、井街宏
  • Organizer: 第43回人工心臓と補助循環懇話会学術集会
  • Place of Presentation: 静岡県・熱海・後楽園ホテル
  • Year and Date: 2015-02-20
• [Presentation] Histopathology image analysis in 4 animal experiments with helical flow total artificial heart (HF-TAH) (2014)
  • Author(s): Wotke Jiri, Vasku Jaromir, Dobsak Petr, 井上雄介、斎藤逸郎、磯山隆、井街宏、阿部裕輔
  • Organizer: 第52回人工臓器学会
  • Place of Presentation: 北海道・札幌・京王プラザホテル札幌
  • Year and Date: 2014-10-19
• [Presentation] 螺旋流完全人工心臓による長期生存ヤギの病態生理 (2014)
  • Author(s): 阿部裕輔、磯山隆、斎藤逸郎、圦本晃海、原伸太郎、李欣陽、村上遥、佐藤雅巳、川瀬由季乃、前野映里奈、田代彩夏、井上雄介、小野俊哉、深沢今日子、石原一彦、高井まどか、小野稔、井街宏
  • Organizer: 第52回人工臓器学会
  • Place of Presentation: 北海道・札幌・京王プラザホテル札幌
  • Year and Date: 2014-10-19
• [Presentation] 完全人工心臓による微小循環血行動態の実時間観察 (2014)
  • Author(s): 井上雄介、斎藤逸郎、磯山隆、小野俊哉、井街宏、阿部裕輔
  • Organizer: 第52回人工臓器学会
  • Place of Presentation: 北海道・札幌・京王プラザホテル札幌
  • Year and Date: 2014-10-19
• [Presentation] Development of the Helical Flow Total Artificial Heart: Results of Animal Experiment with the First Version Model (2014)
  • Author(s): Yusuke Abe,Takashi Isoyama,Itsuro Saito,Terumi yurimoto,Shintaro Hara,Xin-Yang Li,Yusuke Inoue
  • Organizer: 22nd International Society for Rotary Blood Pumps
  • Place of Presentation: アメリカ・サンフランシスコ・ホテルニッコウ
  • Year and Date: 2014-09-25
• [Presentation] Investigation of the right blood pump for the helical flow total artificial heart (2014)
  • Author(s): Yurimoto Terumi,Itsuro Saito, Takashi Isoyama, Yusuke Inoue,Masami Sato, Shintaro Hara, Xin-Yang Li,Haruka Murakami, Yukino Kawase, Toshiya Ono, Kyoko Fukazawa, Kazuhiko Ishihara, Minoru Ono,Yusuke Abe
  • Organizer: 第53回日本生体医工学会大会
  • Place of Presentation: 宮城県・仙台・仙台国際会議場
  • Year and Date: 2014-06-26
• [Presentation] Design concept and elemental technologies of the helical flow total artificial heart (2014)
  • Author(s): "Yusuke Abe, Takashi Isoyama, Itsuro Saito, Terumi Yurimoto, Shintaro Hara, Xin-Yang Li, Haruka Murakami, Yukino Kawase, Masami Sato, Yusuke Inoue, Toshiya Ono, Kyoko Fukazawa, Kazuhiko Ishihara, Madoka Takai, Minoru Ono "
  • Organizer: 第53回日本生体医工学会大会
  • Place of Presentation: 宮城県・仙台・仙台国際会議場
  • Year and Date: 2014-06-26
• [Presentation] 生体調和エレクトロニクス
  • Author(s): 井上雄介
  • Organizer: 日本生体医工学会専門別研究会医用アクチュエーション研究会
  • Place of Presentation: 東京大学（東京都）
  • Invited
• [Presentation] 電気刺激に対する血 管系の応答
  • Author(s): 井上雄介
  • Organizer: 第6回医用生体電磁気学シンポジウム
  • Place of Presentation: 首都大学東京（東京都）
• [Presentation] 埋込型センサのため の生体反応のリアルタイム観察
  • Author(s): 井上雄介
  • Organizer: 東大病院先端医療開発フォーラム
  • Place of Presentation: 東京大学（東京都）
• [Presentation] Development of hybrid blood inflow cannula using titanium core for ventricular assist device
  • Author(s): Yukino Kawase
  • Organizer: IEEE EMBS 2013
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
• [Presentation] The nonlinearity of left atrium volume-pressure relationship and the applicability in the pressure sensor calibration of helical flow total artificial heart (HFTAH)
  • Author(s): Sheng-Yuan Wu
  • Organizer: JSAO & IFAO Joint Congress 2013
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Presentation] ハイブリッド材料を用いた 補助人工心臓用脱血カニューレの開発
  • Author(s): 井上雄介
  • Organizer: 代用臓器再生医学研究会
  • Place of Presentation: 北海道大学（北海道）