Study of a novel sexually dimorphic structure in the hypothalamus
| Project/Area Number |
25670114
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Saitama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Kenichi 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (40315932)
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| Co-Investigator(Renkei-kenkyūsha) |
OGAWA Sonoko 筑波大学, 人間総合研究科(系), 教授 (50396610)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 視床下部 / エストロゲン受容体 / 性差 / 性分化 / エストラジオール / テストステロン |
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| Outline of Final Research Achievements |
Morphological sex differences in the brain underlie sex-biased brain functions. We recently found a hypothalamic area that has a female-biased sex difference in estrogen receptor-alpha expression (hereafter called the area X). In the current study, we examined the morphology of the area X, the effects of sex steroids on formation of the area X, and physiological roles of the area X. We found that the number of neurons in the area X of female mice was greater than that in male mice. Sex steroids affected this female-biased sex difference. Testicular testosterone in the postnatal and pubertal periods acts to decrease the number of neurons in the area X, while ovarian estradiol in the pubertal period acts to increase the number. Physiological function of the area X is still unclear, although our study showed that the area X is not related to female sexual behavior. Further studies are needed to determine the physiological functions of the area X.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Collapsin response mediator protein 4 affects the number of tyrosine hydroxylase-immunoreactive neurons in the sexually dimorphic nucleus in female mice.2013
Author(s)
Iwakura T, Sakoh M, Tsutiya A, Yamashita N, Ohtani A, Tsuda M, Ogawa S, Tsukahara S, Nishihara M, Shiga T, Goshima Y, Kato T, Ohtani-Kaneko R.
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Journal Title
Dev Neurobiol.
Volume: 237
Issue: 7
Pages: 502-517
DOI
Related Report
Peer Reviewed
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[Journal Article] Visualization of oestrogen receptorα-positive neurons in transgenic mice expressing GFP under the control of the oestrogen receptor α promoter.2013
Author(s)
Matsuda, K., Yanagisawa, M., Sano, K., Ochiai, I., Musatov, S., Okoshi, K., Tsukahara, S., Ogawa, S., and Kawata, M.
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Journal Title
European Journal of Neuroscience
Volume: 38
Issue: 2
Pages: 2242-2249
DOI
Related Report
Peer Reviewed
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[Presentation] Regional differences in sex steroid action on formation of sexually dimorphic nuclei in mice.2014
Author(s)
Kanaya M, Tsuda CM, Sagoshi S, Nagata K, Morimoto C, Chaw Kyi Tha Thu, Toda K, Kato S, Ogawa S, Tsukahara S
Organizer
8th International Congress of Neuroendocrinology
Place of Presentation
Sydney, Australia
Year and Date
2014-08-17 – 2014-08-20
Related Report
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