Investigation of mechanism for Aschoff's rule

• Project/Area Number: 25670115
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Chiba University
• Principal Investigator: Takiguchi Masaki 千葉大学, 大学院医学研究院, 教授 (40179578)
• Co-Investigator(Kenkyū-buntansha): 岩瀬 克郎 千葉大学, 大学院医学研究院, 講師 (80322030)
• Co-Investigator(Renkei-kenkyūsha): MATSUMOTO ERIKO 千葉大学, 大学院医学研究院, 技術職員 (20422256)
• Research Collaborator: ARITA EMIKO 千葉大学, 大学院医学研究院, 技術職員 ; TAMAI KEIKO 千葉大学, 大学院医学研究院, 技術補佐員 ; KIMURA RISA 千葉大学, 大学院医学研究院, 技術補佐員 ; TAIRA AKIKO 千葉大学, 大学院医学研究院
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 生物時計 / 神経ペプチド / 時間生物学 / 概日リズム / 神経ぺプチド

Outline of Final Research Achievements

Aschoff's rule states that, under constant light conditions, brighter light shortens period length in diurnal animals and prolongs in nocturnal animals. This rule applies to the animal kingdom widely, but its mechanism remains to be clarified. In this study, we aimed to reveal that light responsiveness of the circadian locomotor rhythm is hypersensitized in a gene-modified mouse strain, which shows enhancement of prolongation in the circadian locomotion period under the constant lightness and then exhibits the phenotype of emphasized Aschoff's rule.

Research Products

• [Journal Article] Novel serum autoantibodies against talin1 in multiple sclerosis: Possible pathogenetic roles of the antibodies (2015)
  • Author(s): Muto M, Mori M, Hiwasa T, Takiguchi M, Iwadate Y, Uzawa A, Uchida T, Masuda H, Sugimoto K, Kuwabara S.
  • Journal Title: Journal of Neuroimmunology Volume: 284 Pages: 30-36
  • DOI: 10.1016/j.jneuroim.2015.05.005
  • NAID: 120007088198
  • Peer Reviewed / Open Access
• [Journal Article] Elevated serum antibody levels against cyclin L2 in patients with esophageal squamous cell carcinoma. (2015)
  • Author(s): Shimada H, Ito M, Kagaya A, Shiratori T, Kuboshima M, Suzuki M, Liu TL, Nabeya Y, Matsubara H, Matsushita K, Nomura F, Takiguchi M, Hiwasa T
  • Journal Title: J Cancer Sci Ther Volume: 7(2) Issue: 02 Pages: 60-66
  • DOI: 10.4172/1948-5956.1000326
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Up-regulation of growth-inhibitory or tumor suppressive genes by overexpression of C/EBPα or C/EBPβ in ras-transformed NIH3T3 cells. (2015)
  • Author(s): Kuroiwa, N., Iwase, K., Morii, S., Takiguchi, M., and Hiwasa, T.
  • Journal Title: Integr. Mol. Med. Volume: 2 Pages: 150-157
  • Peer Reviewed / Open Access
• [Journal Article] Identification of the p53-responsive element in the promoter region of the human decorin gene. (2015)
  • Author(s): Hiwasa T, Iwase K, Suichi T, Hino Y, Kimura R, Shinmen N, Takiguchi M
  • Journal Title: Mol Biol Volume: 4 Issue: 01 Pages: 1-1
  • DOI: 10.4172/2168-9547.1000124
  • Peer Reviewed / Open Access
• [Journal Article] Identification of stroke-associated-antigens via screening of recombinant proteins from the human expression cDNA library (SEREX) (2015)
  • Author(s): Machida, T., Kubota, M., Kobayashi, E., Iwadate, Y., Saeki, N., Yamaura, A., Nomura, F., Takiguchi, M., Hiwasa, T.
  • Journal Title: Journal of Translational Medicine Volume: 13 Issue: 1 Pages: 71-71
  • DOI: 10.1186/s12967-015-0393-4
  • Peer Reviewed / Open Access
• [Journal Article] Circulating anti-filamin C autoantibody as a potential serum biomarker for low-grade gliomas (2014)
  • Author(s): Adachi-Hayama, M., Adachi, A., Shinozaki, N., Matsutani, T., Hiwasa, T., Takiguchi, M., Saeki, N., Iwadate, Y.
  • Journal Title: BMC Cancer Volume: 14 Issue: 1 Pages: 452-452
  • DOI: 10.1186/1471-2407-14-452
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of cell growth by nuclear receptor COUP-TFI: Possible involvement of decorin in growth inhibition (2014)
  • Author(s): Morii, S., Kato, M., Seki, N., Shinmen, N., Iwase, K., Takiguchi, M., Hiwasa, T.
  • Journal Title: Biochemistry & Physiology Volume: S4
  • DOI: 10.4172/2168-9652.s4-001
  • Peer Reviewed / Open Access
• [Journal Article] The secretogranin II gene is a signal integrator of glutamate and dopamine inputs. (2014)
  • Author(s): Iwase, K., Ishihara, A., Yoshimura, S., Andoh, Y., Kato, M., Seki, N., Matsumoto, E., Hiwasa, T., Muller, D., Fukunaga, K., and Takiguchi, M.
  • Journal Title: Journal of Neurochemistry Volume: 128 Issue: 2 Pages: 233-245
  • DOI: 10.1111/jnc.12467
  • Peer Reviewed
• [Journal Article] Efficient subtractive cloning of genes activated by lipopolysaccharide and interferon γ in primary-cultured cortical cells of newborn mice. (2013)
  • Author(s): Miyauchi, O., Iwase, K., Itoh, K., Kato, M., Seki, N., Braissant, O., Bachmann, C., Shozu, M., Sekiya, S., Osada, H., and Takiguchi, M.
  • Journal Title: PLoS ONE Volume: 8 Issue: 11 Pages: e79236-e79236
  • DOI: 10.1371/journal.pone.0079236
  • Peer Reviewed