| Project/Area Number |
25670115
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岩瀬 克郎 千葉大学, 大学院医学研究院, 講師 (80322030)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO ERIKO 千葉大学, 大学院医学研究院, 技術職員 (20422256)
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| Research Collaborator |
ARITA EMIKO 千葉大学, 大学院医学研究院, 技術職員
TAMAI KEIKO 千葉大学, 大学院医学研究院, 技術補佐員
KIMURA RISA 千葉大学, 大学院医学研究院, 技術補佐員
TAIRA AKIKO 千葉大学, 大学院医学研究院
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 生物時計 / 神経ペプチド / 時間生物学 / 概日リズム / 神経ぺプチド |
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| Outline of Final Research Achievements |
Aschoff's rule states that, under constant light conditions, brighter light shortens period length in diurnal animals and prolongs in nocturnal animals. This rule applies to the animal kingdom widely, but its mechanism remains to be clarified. In this study, we aimed to reveal that light responsiveness of the circadian locomotor rhythm is hypersensitized in a gene-modified mouse strain, which shows enhancement of prolongation in the circadian locomotion period under the constant lightness and then exhibits the phenotype of emphasized Aschoff's rule.
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