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Elucidation of local, niche environment that determines pancreatic islet regeneration.

Research Project

Project/Area Number 25670116
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionChiba University

Principal Investigator

MIKI Takashi  千葉大学, 医学(系)研究科(研究院), 教授 (50302568)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords膵島 / 再生 / 前駆細胞 / 糖尿病 / インスリン
Outline of Final Research Achievements

Acceleration of islet regeneration can be a radical therapy for diabetes mellitus. However, the cells involved in the regeneration have not been characterized and its regulatory mechanism remains unclarified. By analyzing the precise regeneration processes in our mouse model, we found that β-cell proliferation is regulated by the changes in β-cell mass, that the mass is maintained by the frequent cell division of the highly proliferative cells, and that several genes involved in the maintenance of stem/progenitor niche environment or in β-cell development are highly expressed during regeneration.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (27 results)

All 2015 2014 2013 Other

All Journal Article (12 results) (of which Peer Reviewed: 10 results,  Open Access: 5 results,  Acknowledgement Compliant: 4 results) Presentation (11 results) (of which Invited: 1 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Distinct action of the alpha-glucosidase inhibitor miglitol on SGLT3, enteroendocrine cells, and GLP1 secretion2015

    • Author(s)
      Lee EY, Kaneko S, Jutabha P, Zhang X, Seino S, Jomori T, Anzai N, Miki T
    • Journal Title

      J Endocrinol

      Volume: 224 Issue: 3 Pages: 205-214

    • DOI

      10.1530/joe-14-0555

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1.2015

    • Author(s)
      Matsushita K, Kitamura K, Rahmutulla B, Tanaka N, Ishige T, Satoh M, Hoshino T, Miyagi S, Mori T, Itoga S, Shimada H, Tomonaga T, Kito M, Nakajima-Takagi Y, Kubo S, Nakaseko C, Hatano M, Miki T, Matsuo M, Fukuyo M, Kaneda A, Iwama A, Nomura F.
    • Journal Title

      Oncotarget

      Volume: 6 Pages: 5102-5117

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Refeeding with glucose rather than fructose elicits greater hepatic inflammatory gene expression in mice2015

    • Author(s)
      Oarada M, et al.
    • Journal Title

      Nutrition

      Volume: 31 Issue: 5 Pages: 757-65

    • DOI

      10.1016/j.nut.2014.11.014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fructose induces KATP channel-independent GIP and GLP-1 secretion and KATP channel-dependent insulin secretion.2015

    • Author(s)
      Seino, Y., Ogata, H., Maekawa, R., Iida, A., Harada, N., Miki, T., Inagaki, N., Tsunekawa, S., Seino, S., Oiso, Y., Hamada, Y.
    • Journal Title

      J Diabetes Investig

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] グルカゴン抑制作用を有する抗糖尿病薬2015

    • Author(s)
      三木隆司
    • Journal Title

      実験医学

      Volume: 33 Pages: 908-913

    • Related Report
      2014 Annual Research Report
  • [Journal Article] KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state2014

    • Author(s)
      Ogata H, Seino Y, Harada N, Iida A, Suzuki K, Izumoto T, Ishikawa K, Uenishi E, Ozaki N, Hayashi Y, Miki T, Inagaki N, Tsunekawa S, Hamada Y, Seino S, Oiso Y
    • Journal Title

      J Endocrinol

      Volume: 222 Issue: 2 Pages: 191-200

    • DOI

      10.1530/joe-14-0161

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Murine insulinoma cell-conditioned medium with ΒETA2/Neurod1 transduction efficiently induces the differentiation of adipose-derived mesenchymal stem cells into β-like cells both in vitro and in vivo.2014

    • Author(s)
      Kawamoto, K., Yabe, S., Konno, M., Ishii, H., Nishida. N., Jun Koseki, J., Fukuda, S., Tomimaru, Y., Hama, N., Wada, H., Kobayashi, S., Eguchi, H., Tanemura, M., Ito, T., Lee, E-Y., Mukai, E., Miki, T., Doki, Y., Mori, M., Hamazaki, T., Nagano, H., Okochi, H.
    • Journal Title

      J Stem Cell Res Ther

      Volume: 4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced vascular endothelial growth factor signaling in islets contributes to β cell injury and consequential diabetes in Spontaneously Diabetic Torii rats.2014

    • Author(s)
      Mukai E, Ohta T, Kawamura H, Lee EY, Morita A, Sasase T, Miyajima K, Inagaki N, Iwanaga T, Miki T.
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 106 Issue: 2 Pages: 303-311

    • DOI

      10.1016/j.diabres.2014.08.023

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] GLP-1の膵α細胞における作用とその機序2014

    • Author(s)
      三木隆司
    • Journal Title

      内分泌糖尿病代謝内科

      Volume: 38 Pages: 424-430

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Refeeding with a standard diet after a 48-h fast elicits an inflammatory response in the mouse liver2013

    • Author(s)
      Oarada M, Miki T, Kohno S, Sakai K, Nikawa T, Yoneyama M, Gonoi T.
    • Journal Title

      J Nutr Biochem

      Volume: (in press) Issue: 7 Pages: 1314-1323

    • DOI

      10.1016/j.jnutbio.2012.10.006

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cephalic phase insulin secretion is KATP channel-independent.2013

    • Author(s)
      Seino, Y., Miki, M., Fujimoto, W., Lee, EY., Takahashi, Y., Minami, K., Oiso, Y., Seino, S.
    • Journal Title

      J Endocrinol

      Volume: 218 Issue: 1 Pages: 25-33

    • DOI

      10.1530/joe-12-0579

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of Type 1 diabetes with nocturnal hypoglycemia after desensitization therapy for insulin allergy.2013

    • Author(s)
      Kitamoto, T., Sakurai, K., Tachibana K., Yokoh H., Ishikawa, K., Miki, T., Yokote K.
    • Journal Title

      Diabetes Care

      Volume: 36 Issue: 7 Pages: 89-89

    • DOI

      10.2337/dc12-2591

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Metabolite sensing and regulation of glucose metabolism in liver. Symposium in A better understanding of liver metabolism by multifaceted approaches2015

    • Author(s)
      Takashi Miki, Eun Young Lee, Yasuhiko Minokoshi
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸交際会議場(兵庫県、神戸市)
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dual roles of a DPP-4 inhibitor on cytoprotection and proliferation of pancreatic β-cells in a mouse model of β-cell injury/regeneration.2014

    • Author(s)
      Mukai, E., Morita, A., Hiratsuka, A., Takatani, T., Lee, EY., Miki, T.
    • Organizer
      50th EASD Annual Meeting
    • Place of Presentation
      Vienna (Austria)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mechanism and physiological roles of glucose sensing in enteroendocrine cells.2014

    • Author(s)
      Lee, EY., Zhang, X., Miki, T.
    • Organizer
      50th EASD Annual Meeting
    • Place of Presentation
      Vienna (Austria)
    • Year and Date
      2014-09-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 単糖類はKATPチャネル依存性の経路と非依存性の経路によりGIP分泌を惹起する2014

    • Author(s)
      尾方秀忠、清野祐介、原田範雄、飯田淳史、鈴木和代、泉本貴子、石川孝太、上西栄太、尾崎信暁、林良敬、三木隆司、稲垣暢也、清野進、濱田洋司、恒川新、大磯ユタカ
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪交際会議場(大阪府、大阪市)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腸内分泌L細胞のグルコース感知と脳への情報伝達2014

    • Author(s)
      李恩瑛 、張錫麟、 三木隆司
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪交際会議場(大阪府、大阪市)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] DPP-Ⅳ阻害薬による膵β細胞死抑制と増殖促進-膵β細胞傷害/再生マウスを用いた検討-2014

    • Author(s)
      森田亜州華、向英里、平塚文乃、高谷具純、李恩瑛、三木隆司
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪交際会議場(大阪府、大阪市)
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] VEGFシグナル阻害はSDTラットにおけるβ細胞傷害と糖尿病発症を抑制する

    • Author(s)
      向英里、太田毅、河村治清、李恩瑛、森田亜州華、笹瀬智彦、稲垣暢也、岩永敏彦、三木隆司
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] インスリン受容体変異マウスの高脂肪食感受性糖尿病発症のメカニズム

    • Author(s)
      李恩瑛 櫻井健一 戸田知得 箕越靖彦 三木隆司
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 高脂肪餌により糖尿病を発症する変異インスリン受容体ノックインマウスの肝臓における遺伝子発現

    • Author(s)
      櫻井健一、李恩瑛、橘香穂里、石川耕、三木隆司
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] Unsuppressed Lipolysis in Adipose Tissue by Insulin Is Critical for Glucose Homeostasis under High Fat Diet

    • Author(s)
      Lee, E-Y., Sakurai, K., Toda,C., Minokoshi, Y., Miki, T.
    • Organizer
      49th EASD Annual Meeting
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Dynamic regulation of metabolite flow between adipose tissues and liver by insulin

    • Author(s)
      Miki, T.
    • Organizer
      第91回日本生理学会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Research-status Report
  • [Book] ギャノング生理学 原書24版、「肝臓の輸送機能と代謝機能」2014

    • Author(s)
      三木隆司
    • Total Pages
      860
    • Publisher
      丸善出版株式会社
    • Related Report
      2013 Research-status Report
  • [Book] イオンチャネル病の全て.「ATP感受性K+チャネルと疾患」2013

    • Author(s)
      三木隆司
    • Total Pages
      100
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Research-status Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.m.chiba-u.ac.jp/class/physiol/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 代謝生理学ホームページ

    • URL

      http://www.m.chiba-u.ac.jp/class/physiol/index.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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