Development of pharmacological treatment of aortic aneurysm

• Project/Area Number: 25670131
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Yokohama City University
• Principal Investigator: ISHIKAWA YOSHIHIRO 横浜市立大学, 医学(系)研究科(研究院), 教授 (40305470)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 薬理学 / 循環器・高血圧 / シグナル伝達 / 病理学 / 外科

Outline of Final Research Achievements

Many drugs that have been developed in the past decade in the cardiovascular field. However, none for treating aortic aneurisms has been developed. It is well known that chronic inflammation or atherosclerosis worsen the fragility of aorta, leading to dilatation or dissection of aorta and thus development of aortic aneurysm. The incidence of aortic aneurysm increases with age. However, surgical treatment is the only treatment choice without pharmacological therapy. From remodeling study of vessels, we have identified pharmacological treatment for suppressing aneurysm.

Research Products

• [Journal Article] Oscillation of cAMP and Ca(2+) in cardiac myocytes: a systems biology approach (2015)
  • Author(s): Kamide T, Okumura S, Ghosh S, Shinoda Y, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Fujita T, Yokoyama U, Sato M, Furutani K, Kitano H, Ishikawa Y
  • Journal Title: The Journal of Physiological Sciences Volume: 65(2) Issue: 2 Pages: 195-200
  • DOI: 10.1007/s12576-014-0354-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Coupling of beta1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes. (2015)
  • Author(s): Tsunematsu T, Okumura S, Mototani Y, Ohnuki Y, Jin H, Cai W, SuitaK, Sato I, Umemura M, Yokoyama U, Sato M, Fujita T, and Ishikawa Y.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 458 Issue: 3 Pages: 531-535
  • DOI: 10.1016/j.bbrc.2015.01.149
  • Peer Reviewed / Open Access
• [Journal Article] A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging. (2015)
  • Author(s): Eguchi H, Umemura M, Kurotani R, Fukumura H, Sato I, Kim J-H, Hoshino Y, Lee J, Amemiya N, Sato M, Hirata K, Sigh DJ, Masuda T, Yamamoto M, Urano T, Yoshida K, Tanigaki K, Yamamoto M, Sato M, Inoue S, Aoki I and Ishikawa Y.
  • Journal Title: Sci. Rep. Volume: 5 Issue: 1 Pages: 9194-9194
  • DOI: 10.1038/srep09194
  • Peer Reviewed / Open Access
• [Journal Article] Prostaglandin E2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling. (2014)
  • Author(s): Yokoyama U, Minamisawa S, Sh ioda A, Ishiwata R, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki II, Nakamura T, and Ishikawa Y
  • Journal Title: Circulation. Volume: 129 Issue: 4 Pages: 487-496
  • DOI: 10.1161/circulationaha.113.004726
  • Peer Reviewed / Open Access
• [Journal Article] Store-operated Ca2 entry (SOCE) Regulates Melanoma Proliferation and Cell Migration. (2014)
  • Author(s): Umemura M, Baljinnyam E, Feske S, De Lorenzo MS, Lai-Hua Xie LH, Feng X, 1, Itoh K, Makino A, Fujita T, Yokoyama U, Iw atsubo M, Chen S, Goydos JS, I shikawa Y, and Iwatsubo K
  • Journal Title: PLoS ONE. Volume: 9 Issue: 2 Pages: e89292-e89292
  • DOI: 10.1371/journal.pone.0089292
  • Peer Reviewed / Open Access
• [Journal Article] Hyperthermia generated with ferucarbotran (Resovis®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells. (2014)
  • Author(s): Sato I, Umemura M, Mitsudo K, Kioi M, Nakashima H, Iwai T Fujita T, Yokoyama U, Okumura S, Feng X, Ito K, Miyajima A, Makino A, Iwai M, Eguchi H, I wai T, and Ishikawa Y.
  • Journal Title: J. Physiol. Sci. Volume: 64 Issue: 3 Pages: 177-183
  • DOI: 10.1007/s12576-014-0309-8
  • Peer Reviewed / Open Access
• [Journal Article] Decreased serum osmolality promotes ductus arteriosus constriction. (2014)
  • Author(s): Aoki R, Yokoyama U, Ichikawa Y, Taguri M, Kumagaya S, Ishiwata R, Yanai C, Fujita S, Umemura M, Fujita T, Okumura S, Sato M, Minamisawa S, Asou T, Masuda M, Iwasaki S, Nishimaki S, Seki K, Yokota S, Ishikawa Y.
  • Journal Title: Cardiovascular Research Volume: 104(2) Issue: 2 Pages: 326-36
  • DOI: 10.1093/cvr/cvu199
  • Peer Reviewed / Open Access
• [Journal Article] Three-Dimensional Multilayers of Smooth Muscle Cells as a New Experimental Model for Vascular Elastic Fiber Formation Studies. (2014)
  • Author(s): Ishiwata R, Yokoyama U, Matsusaki M, Yoshiya A, Kadowaki K, Ichikaww Y, Umemura M, Fujita T, Minamisawa S, Shimoda H, Mitsuru Akashi M, and Ishikawa Y.
  • Journal Title: Atherosclerosis. Volume: 233 Issue: 2 Pages: 590-600
  • DOI: 10.1016/j.atherosclerosis.2014.01.045
  • Peer Reviewed / Open Access
• [Journal Article] Protection of cardiomyocytes from the hypoxia-mediated injury by a peptide targeting the activator of G-protein signaling 8. (2014)
  • Author(s): Sato M, Hiraoka M, Suzuki H, Sakima M, Mamun, AA, Yamane Y, Fujita T, Yokoyama U, Okumura S, and Ishikawa Y.
  • Journal Title: PLoS ONE. Volume: 9 Issue: 3 Pages: e91980-e91980
  • DOI: 10.1371/journal.pone.0091980
  • Peer Reviewed / Open Access
• [Journal Article] Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses (2014)
  • Author(s): Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y
  • Journal Title: J Clin Invest. Volume: 124 Issue: 6 Pages: 2785
  • DOI: 10.1172/jci64784
  • URL: https://localhost/en/publications/36b42ba8-faa2-4af8-8b0f-f7a856c64b49
  • Peer Reviewed / Open Access
• [Journal Article] Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3. (2014)
  • Author(s): Tsutsumi YM, Tsutsumi R, Hamaguchi E, Sakai Y, Kasai A, Ishikawa Y, Yokoyama U, and Tanaka K.
  • Journal Title: Cardiovasc Diabetol. Volume: 13 Issue: 1 Pages: 132-132
  • DOI: 10.1186/s12933-014-0132-9
  • Peer Reviewed / Open Access
• [Journal Article] Geranylgeranylacetone protects the heart via caveloae and caveolin-3. (2014)
  • Author(s): Tsutsumi YM, Tsutsumi R, Hirokawa YT, Sakai Y, Hamaguchi E, Ishikawa Y, Yokoyama U, Kasai A, Kambe N, and Tanaka K.
  • Journal Title: Life Sciences. Volume: 101 Issue: 1-2 Pages: 43-48
  • DOI: 10.1016/j.lfs.2014.02.019
  • Peer Reviewed / Open Access
• [Journal Article] Epacl increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling. (2014)
  • Author(s): Baljinnyam E, Umemura M, C huang C, De Lorenzo M, Iwatsubo M, Chen S, Goydos J, Ishikawa Y, Whitelock J, and Iwatsubo K.
  • Journal Title: Pigment Cell & Melanoma Research. Volume: (Epub ahead of print) Issue: 4 Pages: 611-620
  • DOI: 10.1111/pcmr.12250
  • Peer Reviewed
• [Journal Article] A Case of R-II-B Type Single Coronary Artery Evaluated by Multi-Detector Computed Tomography and Coronary Angiography. (2014)
  • Author(s): Narikawa M, Kiyokuni M, Umemura M, Kawashima C, Doi H, Hisa A, Tomari S, Mitsuhashi T, Ishikawa Y and Endo T.
  • Journal Title: J Clin Exp Cardiolog, Volume: 5 Pages: 10-10
  • Peer Reviewed
• [Journal Article] Impaired NO Production and Increased Blood Pressure in Systemic Heterozygous ATP2B1 Null Mice. (2014)
  • Author(s): Fujiwara A, Hirawa N, Fujita M, Kobayashi Y, Okuyama Y, Yatsu K, Katsumata M, Yamamoto y, Ichihara N, Saka S, Toya Y, Yasuda G, Tabara Y, Miki T, Ueshima H, Ishikawa Y, and Umemura S
  • Journal Title: J Hypertension. Volume: 32 Issue: 7 Pages: 1415-1423
  • DOI: 10.1097/hjh.0000000000000206
  • Peer Reviewed / Open Access
• [Journal Article] Role of Cyclic AMP Sensor Epac1 in Masseter Muscle Hypertrophy and Myosin Heavy Chain Transition Induced by 2-Adrenoceptor Stimulation. (2014)
  • Author(s): Ohnuki Y, Umeki D, Mototani Y, Jin H, Cai W, Shiozawa K, Suita K, Saeki Y, Fujita T, Ishikawa Y, and Okumura S.
  • Journal Title: J. Physiol. Volume: 592 Issue: 24 Pages: 5461-5475
  • DOI: 10.1113/jphysiol.2014.282996
  • Peer Reviewed
• [Journal Article] Obstructive Sleep Apnea and Hypertension:A New Way to Go. (2014)
  • Author(s): Ishikawa Y.
  • Journal Title: J Sleep Disorders Ther. Volume: 3 Pages: 4-4
  • Peer Reviewed
• [Journal Article] Disruption of Epac1 decreasesphosphorylation of phospholamban and protects theheart against stresses. (2014)
  • Author(s): Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin HL, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita Km Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, and Ishikawa Y.
  • Journal Title: J. Clin. Invest. Volume: 印刷中
• [Journal Article] Deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertension. (2013)
  • Author(s): Ohsawa M, Tamura K, Wakui H, Maeda A, Dejima T, Kanaoka T, Azushima K, Uneda K, Tsurumi-Ikeya Y, Kobayashi R, Matsuda M, Uchida S, Toya Y, Kobori H, Nishiyama A, Yamashita A, Ishikawa Y, Umemura S.
  • Journal Title: Kidney Int. Volume: 86(3) Issue: 3 Pages: 570-81
  • DOI: 10.1038/ki.2014.95
  • Peer Reviewed / Open Access
• [Journal Article] The prostanoid EP4 receptor and its signaling pathway. (2013)
  • Author(s): Yokoyama U, Iwatsubo K, Umemura M, Fujita T, and Ishikawa Y.
  • Journal Title: Pharmacol Rev. Volume: 65 Issue: 3 Pages: 1010-1052
  • DOI: 10.1124/pr.112.007195
  • Peer Reviewed
• [Journal Article] Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of MnSOD via the Sirtl/FoxO3a Pathway. (2013)
  • Author(s): Lai L, et al.
  • Journal Title: Circulation. Volume: 127 Issue: 16 Pages: 1692-1701
  • DOI: 10.1161/circulationaha.112.001212
  • Peer Reviewed
• [Journal Article] A role for Piezo2 in EPAC1-dependent mechanical allodynia. (2013)
  • Author(s): Eijkelkamp N, Linley JE, Torres JM, Bee L, Dickenson AH, Gringhuis M, Minett MS, Hong GS, Lee E, Oh U, Ishikawa Y, Zwartkuis FJ, Cox JJ, and Wood, J N.
  • Journal Title: Nature Commun. Volume: 4 Issue: 1 Pages: 1682-1682
  • DOI: 10.1038/ncomms2673
  • Peer Reviewed
• [Journal Article] Hight-dose zoledronic acid narrows the periodontal space in rats. (2013)
  • Author(s): Okamoto Y, Hirota M, Monden Y, Murata S, Koyama C, Mitsudo K, Iwai T, Ishikawa Y, and Tohnai I.
  • Journal Title: Int J Oral Maxillofac Surg. Volume: 2 Issue: 5 Pages: 627-631
  • DOI: 10.1016/j.ijom.2012.11.011
  • Peer Reviewed
• [Journal Article] Balancing GRK2/ Epac1levels prevents and relieves chronic pain. (2013)
  • Author(s): Wang H, Heijnen CJ, van Velth oven CTJ, Willemen HLDM, Ishikawa Y, Zhang X, Sood AK, Vroon A, Eijkelkamp N, and Kavelaars A.
  • Journal Title: J. Clin. Invest. Volume: 123 Issue: 12 Pages: 5023-5034
  • DOI: 10.1172/jci66241
  • Peer Reviewed
• [Journal Article] Adenylyl cyclase type 5 in cardiac disease, metabolism and aging. (2013)
  • Author(s): Vatner SF, Park M, Yan L, Lee G, Lai L, Iwatsubo K, Ishikawa Y, Pessin J, and Vatner DE
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 305 Issue: 1 Pages: H1-H8
  • DOI: 10.1152/ajpheart.00080.2013
  • Peer Reviewed
• [Presentation] Cardiac overexpression of Translationally Controlled Tumor Protein (TCTP) prevents the development of Dihydroartemisinin (DHA)-induced heart. (2015)
  • Author(s): Cai W, Fujita T, Hidaka Y, Jin H, Hasegawa N, Ishikawa Y
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場、リーガロイヤルホテル大阪、堂島リバーフォーラム、ＡＢＣホール(大阪府）
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Transient receptor potential cation channel 3 (TRPC3) regulates tumor proliferation and migration of BRAF wild type human malignant melanoma. (2015)
  • Author(s): Oda K, Umemura M, Baljinntam E, Yamaguchi Y, Aihara M, Iwatsubo K, Ishikawa Y.
  • Organizer: The 106th American Association for Cancer Research Annual meeting.
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-18 – 2015-04-22
• [Presentation] Methotrexate derivative with intrinsic magnetism. (2015)
  • Author(s): Umemura M, Katsumata M, Sato I, Nagasako A, Aoyama H, Makino A, Ohatake M, Oda K, Eguchi H, Ishikawa Y.
  • Organizer: The 106th American Association for Cancer Research Annual meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-18 – 2015-04-22
• [Presentation] Simultaneous hyperthermic-chemotherapy for glioblastoma using a single anti-cancer compound with magnetism. (2015)
  • Author(s): Ohtake M, Umemura M, Sato I, Oda K, Nagasako A, Makino A, Aoyama H, Katsumata M, Eguchi H, Kawahara N , Ishikawa Y
  • Organizer: The 106th American Association for Cancer Research Annual meeting.
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-18 – 2015-04-22
• [Presentation] A novel methotrexate derivative with intrinsic magnetism. (2015)
  • Author(s): Katsumata M, Umemura M, Sato I, Ohtake M, Oda K, Nagasako A, Makino A, Aoyama H, Eguchi H, Ishikawa Y.
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県）
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Magnetized paclitaxel derivative for novel triple negative breast cancer therapy. (2015)
  • Author(s): Makino A, Umemura M, Sato I, Katsumata M, Nagasako A, Oda K, Ohtake M, Aoyama H, Eguchi H, Ishikawa Y.
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県）
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] A novel methotrexate derivative with intrinsic magnetism. (2015)
  • Author(s): Katsumata M, Umemura M, Sato I, Ohtake M, Oda K, Nagasako A, Makino A, Aoyama H, Eguchi H, Ishikawa Y.
  • Organizer: 第88回日本薬理学会
  • Place of Presentation: 名古屋国際会議場（愛知県）
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] プロスタグランディンE－EP4はfibulin-1を介して生理的・病的血管内膜肥厚の形成に関与する． (2014)
  • Author(s): 矢内千春, 横山詩子, 熊谷 駿, 手島隆之, 佐藤綾美, 石川義弘
  • Organizer: 第13回日本心臓血管発生研究会
  • Place of Presentation: 磐梯熱海温泉 ホテル 華の湯(福島県）
  • Year and Date: 2014-10-17 – 2014-10-18
• [Presentation] 抗ヘルペス薬による心房細動抑制． (2014)
  • Author(s): 吹田憲治, 藤田孝之, 奥村 敏, 石川義弘
  • Organizer: 第131回日本薬理学会関東部会
  • Place of Presentation: 横浜市立大学医学部ﾍﾎﾞﾝﾎｰﾙ（神奈川県）
  • Year and Date: 2014-10-11
• [Presentation] A novel paclitaxel with intrinsic magnetism. (2014)
  • Author(s): Makino A, Umemura M, Sato I, Oda K, Otake M, Nagasako A, Eguchi H, Ishikawa Y.
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Development of combination therapy with cisplatin and hyperthermia generated with ferucarbotran (Resovist) in an alternating magnetic field for oral cancer. (2014)
  • Author(s): Sato I, Mitsudo K, Umemura M, Nakashima H, Kioi M, Eguchi H, Ishikawa Y,Tohnai.I
  • Organizer: The 6th Asian Congress of Hyperthermic Oncology (ACHO)
  • Place of Presentation: 福井県民ホール、福井市地域交流プラザ（福井県）
  • Year and Date: 2014-09-05 – 2014-09-06
• [Presentation] EPAC1 plays an important role in regulation of renin and AQP2 expression in the kidney of mice. (2014)
  • Author(s): Jin H, Fujita T, Cai W, Hidaka Y, Sagara S, Kubota K, Suita K, Ishikawa Y.
  • Organizer: European Society of Cardiorogy Congress.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Prostaglandin E2-EP4 plays a protective role against cardiac fibrosis. (2014)
  • Author(s): Ishiwata R, Yokoyama U, Inoue S, Ichikawa Y, Ishikawa Y.
  • Organizer: European Society of Cardiorogy Congress.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Cardiac overexpression ofure. Chronic Treatment with Dihydroartemisinin, a TCTP Down-regulating Agent, Results in Cardiac Dysfunction in Mice． (2014)
  • Author(s): Cai W, Fujita T, Hidaka Y, Jin H, K. Sagara S, Kubota K, Suita K, Ishikawa Y.
  • Organizer: European Society of Cardiorogy Congress.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced atrial fibrillation in mice. (2014)
  • Author(s): Suita K, Fujita T, Cai W, Hidaka Y, Jin H, Jin M, Okumura S, Ishikawa Y.
  • Organizer: European Society of Cardiorogy Congress.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] 体液量調節におけるEPAC1の役割についての検討. (2014)
  • Author(s): Jin H, Fujita T, Cai W, Hidaka Y, Sagara S, Suita K, Ishikawa Y
  • Organizer: 第５７会日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] ヒト大動脈瘤組織におけるPGE2-EP4誘導性分泌タンパク質の網羅的解析. (2014)
  • Author(s): 石渡 遼, 横山詩子, 荒川憲昭, 安田章沢, 郷田素彦, 鈴木伸一, 益田宗孝, 石川義弘
  • Organizer: 第35回日本循環制医学会総会
  • Place of Presentation: 九州大学医学部百年講堂（福岡県）
  • Year and Date: 2014-07-04 – 2014-07-05
• [Presentation] 心臓型アデニル酸シクラーゼの選択的阻害剤ビダラビンによる心房細動抑制. (2014)
  • Author(s): 吹田憲治, 藤田孝之, 蔡 文倩, 金 慧玲, 奥村 敏, 石川義弘
  • Organizer: 第35回日本循環制御医学会総会
  • Place of Presentation: 九州大学医学部百年講堂（福岡県）
  • Year and Date: 2014-07-04 – 2014-07-05
• [Presentation] MRI造影剤フェルカルボトランを用いた新しい温熱化学療法の開発. (2014)
  • Author(s): 佐藤 格, 光藤健司, 梅村将就, 宮島章嘉, 中島英行, 來生 知, 石川義弘, 藤内 祝.
  • Organizer: 第38回日本頭頚部癌学会
  • Place of Presentation: 東京ファッションタウンビルホール（東京都）
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] Nuclear Factor kappa B Inhibition Promotes Closure of the Rat Ductus Arteriosus. (2014)
  • Author(s): Kajimura I, Yokoyama U, Ishikawa Y, Minamisawa S.
  • Organizer: Experimental Biology Annual Meeting.
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-26 – 2014-04-30
• [Presentation] Prostaglandin E2 receptor EP4 signaling in vascular smooth muscle cells decreases aortic elasticity. (2014)
  • Author(s): Ichikawa Y, Yokoyama U, Ishikawa Y.
  • Organizer: Experimental Biology Annual Meeting.
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-26 – 2014-04-30
• [Presentation] Development of thermochemotherapy using cisplatin and ferucarbotran (Resovist®) in head and neck cancer. (2014)
  • Author(s): Sato I, Umemura M, Mitsudo K, Feng X, Nakashima H, Kioi M, Eguchi H, Tohnai I, Ishikawa Y
  • Organizer: The 105th American Association for Cancer Research Annual meeting.
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-05 – 2014-04-09
• [Presentation] A novel treatment for triple-negative breast cancer using intrinsic magnetized paclitaxel. (2014)
  • Author(s): Umemura M, Makino A, Sato I, Feng X, Iwai M, Oda K, Miyajima A, Otake M, Nagasako A, Matsuo K, Eguchi H, and Ishikawa Y.
  • Organizer: The 105th American Association for Cancer Research Annual meeting.
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-05 – 2014-04-09
• [Presentation] Store-operated Ca2+ entry (SOCE) regulates melanoma progression. (2013)
  • Author(s): Umemura M, Baljinnyam E, Lorenzo M.S.De, Feske S, Xie L, Ishikawa Y, and Iwatsubo K
  • Organizer: The 104 American Association for Cancer Research Annual meeting.
  • Place of Presentation: Washington DC, USA
• [Presentation] Application of a novel nano-magnetic anti-cancer drug to hyperthermia. (2013)
  • Author(s): Umemura M, Fukumura H, Sato I, Feng X, Izuka H, Eguchi H, Ishikawa Y.
  • Organizer: The 104 American Association for Cancer Research Annual meeting.
  • Place of Presentation: Washington DC, USA
• [Presentation] Targeted drug delivery system and magnetic resonance imaging with intrinsic ferromagnetic nano-particle compound. (2013)
  • Author(s): Eguchi H, Hirata K, Kurotani R, Fukumura H, Singh D.J, Yamamoto M, Sato I, Umemura M, Yamamoto M, Nagashima Y, Ishikawa Y.
  • Organizer: The 104 American Association for Cancer Research Annual meeting.
  • Place of Presentation: Washington DC, USA
• [Presentation] Thermochemotherapy with controlled drug delivery using a novel magnetic anti-cancer drug. (2013)
  • Author(s): Sato I, Mitsudo K, Umemura M, Feng X, Fukumura H, Eguchi H, Nakashima H, Kioi M, Tohnai, Ishikawa Y..
  • Organizer: The 104 American Association for Cancer Research Annual meeting.
  • Place of Presentation: Washington DC, USA
• [Presentation] Novel thermo-chemotherapy using a new magnetic anti-cancer drug. (2013)
  • Author(s): Sato I, Umemura M, Mitsudo K, Feng X, Baba J, Nakashima H, Kioi M, Eguchi H, Tohnai I, Ishikawa Y.
  • Organizer: The 104 American Association for Cancer Research Annual meeting, Washington.
  • Place of Presentation: Washington DC, USA
• [Presentation] Inhibitor of cardiac adenylyl cyclase prevents atrial fibrillation in mice. HD Physiology. (2013)
  • Author(s): Suita K, Cai W, Jin H, Jin M, Fujita T, Okumura S, Ishikawa Y.
  • Organizer: HD Physiology, the 2nd International Symposium.
  • Place of Presentation: 丸ノ内ＭＹＰＬＡＺＡ（東京都）
• [Presentation] Mouse Overexpressing Prostaglandin E Receptor EP4 in Vascular Smooth Muscle Cells Decreased Elasticity of the Aorta. (2013)
  • Author(s): Ichikawa Y, Yokoyama U, Jin M, Ishikawa Y.
  • Organizer: The 7th TAKAO International symposium.
  • Place of Presentation: 国立オリンピック記念青少年総合センター（東京都）
• [Presentation] Prostaglandin E2-EP4 signaling promotes secretion of the lipid-relating proteoglycan buglycan in human coronary arteries during development. (2013)
  • Author(s): Kumagaya S, Yokoyama U, Sato A, Nishihara H, Inoue T, Minamisawa S, Ishikawa Y.
  • Organizer: The 7th TAKAO International symposium.
  • Place of Presentation: 国立オリンピック記念青少年総合センター（東京都）
• [Presentation] Prostaglandin E2-EP4 signaling inhibits vascular elastic fiber formation in the ductus arteriosus. (2013)
  • Author(s): Ishiwata R, Yokoyama U, Jin M, Masuda M, Asou T, Sugimoto Y, Aoki H, Nakamura T, Minamisawa S, Ishikawa Y.
  • Organizer: The 7th TAKAO International symposium.
  • Place of Presentation: 国立オリンピック記念青少年総合センター（東京都）
• [Presentation] Cardiac overexpression of Translationally Controlled Tumor Protein (TCTP) prevents the development of doxorubicin-induced heart failure. (2013)
  • Author(s): Fujita T, Cai W, Hidaka Y, Jin H, Jin M, Suita K, Ishikawa Y.
  • Organizer: European Socirty of Cardiology.
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] A novel nano-magnetic particle with cytotoxic and a novel technology of designing intrinsic ferromagnetism compound. (2013)
  • Author(s): Umemura M, Eguchi H, Ishikawa Y.
  • Organizer: The 72nd Annual Meeting of the Japanese Cancer Association.
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] A conventional anti-cancer drug designed artificially with ferromagnetic, EI2573M. (2013)
  • Author(s): Iwai M, Umemura M, Sato I, Nagasako A, Feng X, Hoshino Y, Inoue S, Aoki I, Eguchi H. Ishikawa Y
  • Organizer: The 72nd Annual Meeting of the Japanese Cancer Association.
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] Therapeutic Effect of EP4 Antagonist on Advanced Abdominal Aortic Aneurysm. (2013)
  • Author(s): Yokoyama U, Ishiwata R, Arakawa N, Suzuki S, Masuda M, Ishikawa Y.
  • Organizer: The 86th Scientific Session, American Heart Association.
  • Place of Presentation: Dallas, USA
• [Presentation] Decreased Serum Osmolality Augments the Closure of the Ductus Arteriosus in Neonates. (2013)
  • Author(s): Yokoyama U, Aoki R, Ichikawa Y, Iwasaki S, Seki K, Nishimaki S, Yokota S, Minamisawa S, Ishikawa Y.
  • Organizer: The 86th Scientific Session, American Heart Association.
  • Place of Presentation: Dallas, USA
• [Presentation] Prostaglandin E2 Receptor EP4 Signaling in Vascular Smooth Muscle Decreased Elasticity of the Aorta. (2013)
  • Author(s): Ichikawa Y, Yokoyama U, Iwamoto M, Yokota S, Minamisawa S, Ishikawa Y.
  • Organizer: The 86th Scientific Session, American Heart Association.
  • Place of Presentation: Dallas, USA
• [Presentation] Anti-fibrotic Effect of Prostaglandin E2-EP4 in the Heart. (2013)
  • Author(s): Ishiwata R, Yokoyama U, Inoue S, Ichikawa Y, Ishikawa Y.
  • Organizer: The 86th Scientific Session, American Heart Association.
  • Place of Presentation: Dallas, USA
• [Presentation] 温熱治療における新規磁性抗がん剤の役割 (2013)
  • Author(s): 石川義弘
  • Organizer: 第30回日本ハイパーサーミア学会
  • Place of Presentation: 横浜シンポジア（神奈川県）
  • Invited
• [Presentation] 新規抗癌剤を用いた口腔癌に対するハイパーサーミアの開発. (2013)
  • Author(s): 佐藤 格, 光藤健司, 梅村将就, 江口晴樹, 石川義弘, 藤内 祝
  • Organizer: 第37回日本頭頸部癌学会
  • Place of Presentation: 京王プラザホテル（東京都）
• [Presentation] 出生後血清浸透圧変化からみた動脈管開存症発症リスク因子の検討. (2013)
  • Author(s): 青木理加, 横山詩子, 藤田秀次郎, 市川泰広, 岩崎志穂, 関 和男, 西巻 滋, 横田俊平, 石川義弘
  • Organizer: 第49回日本周産期新生児学会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] EP4シグナル制御による大動脈瘤の治療開発. (2013)
  • Author(s): 石渡 遼, 横山詩子, 石川義弘
  • Organizer: 新学術領域 「自然炎症」+「脂質マシナリー」若手ワークショップ
  • Place of Presentation: ルネッサンスリゾート鳴門（徳島県）
• [Presentation] 大動脈瘤進展におけるプロスタグランディンE-EP4の役割. (2013)
  • Author(s): 石渡 遼, 横山詩子, 石川義弘
  • Organizer: 第6回大動脈分子病態研究会
  • Place of Presentation: 久留米大学循環器病研究所（福岡県）
• [Presentation] 抗がん作用を有する新規磁性微粒子を用いたハイパーサーミアへの応用. (2013)
  • Author(s): 佐藤 格, 光藤健司, 梅村将就, 來生 知, 中島英行, 馮 先鋒, 江口晴樹, 石川義弘, 藤内 祝
  • Organizer: 第30回ハイパーサーミア学会
  • Place of Presentation: 横浜シンポジア（神奈川県）
• [Presentation] Prostaglandin Eシグナルによるlysyl oxidase分解亢進が動脈管弾性線維の形成不良を引き起こす. (2013)
  • Author(s): 南沢 享, 横山詩子, 青木浩樹, 中邨智之, 石川義弘
  • Organizer: 生理研研究会―心血管膜輸送分子の構造・機能・病態の統合的研究戦略
  • Place of Presentation: 自然科学研究機構 生理学研究所（愛知県）
• [Presentation] 心臓型アデニル酸シクラーゼの選択的阻害剤ビダラビンによる不整脈治療の可能性. (2013)
  • Author(s): 吹田憲治, 藤田孝之, 石川義弘
  • Organizer: 生理学研究所研究会, ―心血管膜輸送分子の構造・機能・病態の統合的研究戦略.
  • Place of Presentation: 自然科学研究機構 生理学研究所（愛知県）
• [Presentation] 新生児期における浸透圧感受性TRPチャネルの役割. (2013)
  • Author(s): 横山詩子, 青木理加, 南沢 享, 石川義弘
  • Organizer: 筋生理の集い
  • Place of Presentation: 東京慈恵会医科大学 (東京都）
• [Book] 標準生理学 第8版 第29章「赤血球」 (2014)
  • Author(s): 石川義弘
  • Total Pages: 1140
  • Publisher: 医学書院
• [Book] 標準生理学 第8版 第39章 「局所循環」 (2014)
  • Author(s): 石川義弘
  • Total Pages: 1140
  • Publisher: 医学書院
• [Book] 遺伝子医学ＭＯＯＫ24 最新生理活性脂質研究-実験手法、基礎的知識とその応用- 「大動脈瘤の進展とPGE2」 (2013)
  • Author(s): 横山詩子、金美花、石川義弘
  • Total Pages: 312
  • Publisher: メディカルドゥ社
• [Remarks] 横浜市立大学大学院医学研究科 循環制御医学 ホームページ
  • URL: http://www-user.yokohama-cu.ac.jp/~seiri1/index.html
• [Remarks] 横浜市立大学大学院医学研究科 循環制御医学 ホームページ
  • URL: http://www-user.yokohama-cu.ac.jp/~seiri1/
• [Patent(Industrial Property Rights)] グルタミン酸による動脈管開存症の予防又は治療 (2015)
  • Inventor(s): 横山詩子、石川義弘、藤田秀次郎
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-02-17
  • Overseas
• [Patent(Industrial Property Rights)] 三次元細胞集合体の作製方法 (2015)
  • Inventor(s): 横山詩子、石川義弘、金子真、佐久間臣耶、新井史人
  • Industrial Property Rights Holder: 横浜市立大学、大阪大学、名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-033064
  • Filing Date: 2015-02-23
• [Patent(Industrial Property Rights)] 三次元組織体及びその製造方法 (2014)
  • Inventor(s): 横山詩子、石川義弘、明石満、松崎典弥
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学、国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-10-09
  • Overseas
• [Patent(Industrial Property Rights)] 三次元組織体及びその製造方法 (2013)
  • Inventor(s): 横山詩子、石川義弘、明石満、松崎典弥
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学、国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-212966
  • Filing Date: 2013-10-10