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The analysis for molecular mechanism of lifespan regulation by RNA binding protein

Research Project

Project/Area Number 25670138
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

AKIYAMA Tetsu  東京大学, 分子細胞生物学研究所, 教授 (70150745)

Project Period (FY) 2013-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords寿命 / 老化 / 脂肪組織 / 分化
Outline of Final Research Achievements

Mex-3B is an RNA-binding protein, but its function is poorly understood, We found that Mex-3B-deficient mice are long-lived. We therefore attempted to elucidate the molecular mechanisms underlying lifespan regulation by Mex-3B.We found that Mex-3B deficient mice were resistant to obesity and showed significantly decreased adipocyte tissue weights. In addition, we found that Mex-3B were down-regulated in adipocyte tissues by caloric restriction, a well-known method to extend lifespan. These results suggest that Mex-3B regulates lipid metabolism in adipocyte tissues, and Mex-3B deficiency prolongs lifespan by a mechanism similar to that involved in lifespan extension by caloric restriction.
We also performed adipocyte differentiation assays using Mex-3B-deficient cells. We found that Mex-3B deficiency suppressed adipocyte differentiation. Thus, lifespan extension and resistance to obesity seen in Mex-3B-deficient mice may be resulted from suppression of adipocyte differentiation.

Report

(2 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (18 results)

All 2014 2013

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 5 results) Presentation (6 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] The miR-363-GATA6-Lgr5 pathway is critical for colorectal tumorigenesis2014

    • Author(s)
      Tsuji S
    • Journal Title

      Nat. Commun.

      Volume: 5 Issue: 1 Pages: 3150-3150

    • DOI

      10.1038/ncomms4150

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PCDH10 is required for the tumorigenicity of glioblastoma cells2014

    • Author(s)
      Kanae Echizen, Mitsutoshi Nakada , Tomoatsu Hayashi, Hemragul Sabit, Takuya Furuta, Miyuki Nakai, Ryo Koyama-Nasu, Yukiko Nishimura, Kenzui Taniue, Yasuyuki Morishita, Shinji Hirano, Kenta Terai, Tomoki Todo, Yasushi Ino, Akitake Mukasa, Shunsaku Takayanagi, Ryohei Ohtani, Nobuhito Saito, Tetsu Akiyama
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 444 Issue: 1 Pages: 13

    • DOI

      10.1016/j.bbrc.2013.12.138

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia2014

    • Author(s)
      Takanori Onouchi, Katsunori Kobayashi, Kazuyoshi Sakai, Atsushi Shimomura, Ron Smits, Chiho Sumi-Ichinose, Masafumi Kurosumi Keizo Takao, Ryuji Nomura, Akiko Iizuka-Kogo, Hidenori Suzuki,Kazunao Kondo, Tetsu Akiyama Tsuyoshi Miyakawa Riccardo Fodde and Takao Senda, Riccardo Fodde, Takao
    • Journal Title

      Molecular Brain

      Volume: 7 Issue: 1 Pages: 21-21

    • DOI

      10.1186/1756-6606-7-21

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The miR-1-NOTCH3-Asef Pathway Is Important for Colorectal Tumor Cell Migration2013

    • Author(s)
      Shiori Furukawa,Yoshihiro Kawasaki, Masaya Miyamoto, Masaya Hiyoshi,Joji Kitayama, Tetsu Akiyama
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 11 Pages: e80609-e80609

    • DOI

      10.1371/journal.pone.0080609

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The pleiotrophin-ALK axis is required for tumorigenicity of glioblastoma stem cells2013

    • Author(s)
      R Koyama-Nasu, R Haruta, Y Nasu-Nishimura, K Taniue, Y Katou, K Shirahige, T Todo, Y Ino, A Mukasa, N Saito, M Matsui, R Takahashi, A Hoshino-Okubo, H Sugano, E Manabe, K Funato and T Akiyam
    • Journal Title

      Oncogene

      Volume: 33 Issue: 17 Pages: 2236

    • DOI

      10.1038/onc.2013.168

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in the localization of the APC-Asef/Asef2 complex between APC wild-type and mutant cells2013

    • Author(s)
      Yoshihiro Kawasaki, Shiori Furukawa, Rina Sato, Tetsu Akiyama
    • Journal Title

      Cancer Sci.

      Volume: 8 Issue: 8 Pages: 1135-1138

    • DOI

      10.1111/cas.12180

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The critical role of cyclin D2 in cell cycle progression and tumorigenicity of glioblastoma stem cells2013

    • Author(s)
      R Koyama-Nasu, Y Nasu-Nishimura, T Todo, Y Ino, N Saito, H Aburatani, K Funato, K Echizen, H Sugano, R Haruta, M Matsui, R Takahashi, E Manabe, T Oda and T Akiyama
    • Journal Title

      Oncogene

      Volume: 32 Issue: 33 Pages: 3840

    • DOI

      10.1038/onc.2012.399

    • URL

      https://pure.teikyo.jp/en/publications/e70c2970-6caa-4438-92cd-ad93bd0eb776

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the guanylate kinase domain from Discs large homolog 1 (DLG1/SAP97)2013

    • Author(s)
      Shinji Mori, Yuta Tezuka, Akihiko Arakawa, Noriko Handa, Mikako Shirouzu, Tetsu Akiyama, Shigeyuki Yokoyama
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 435 Issue: 3 Pages: 334-338

    • DOI

      10.1016/j.bbrc.2013.04.056

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alendronate attenuates eosinophilic airway inflammation associated with suppression of Th2 cytokines, Th17 cytokines, and eotaxin-2.2013

    • Author(s)
      Oh Sasaki, Mitsuru Imamura, Yusuke Yamazumi, Hiroaki Harada, Taku Matsumoto, Katsuhide Okunishi, Kazuyuki Nakagome, Ryoichi Tanaka, Tetsu Akiyama, Kazuhiko Yamamoto and Makoto Dohi
    • Journal Title

      J. Immunol

      Volume: 191 Issue: 6 Pages: 2879-2889

    • DOI

      10.4049/jimmunol.1300460

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epub ahead of print2013

    • Author(s)
      Toki H, Inoue M, Motegi H, Minowa O, Kanda H, Yamamoto N, Ikeda A, Karashima Y, Matsui J, Kaneda H, Miura I, Suzuki T, Wakana S, Masuya H, Gondo Y, Shiroishi T, Akiyama T, Yao R, Noda T
    • Journal Title

      Cancer Sci

      Volume: PMID: 23551873 Issue: 7 Pages: 937-944

    • DOI

      10.1111/cas.12161

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased apoptosis and persistence of the common nephric duct during the development of an aberrant vesicoureteral junction in dlg1 gene-targeted mice2013

    • Author(s)
      Akiko Iizuka-Kogo, Tetsu Akiyama, Takao Senda
    • Journal Title

      Anat Rec.

      Volume: 296 Issue: 12 Pages: 1936-1942

    • DOI

      10.1002/ar.22814

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] ”Long non-coding RNA ASBEL required for tumorigenicity of colon cancer2014

    • Author(s)
      Kenzui Taniue, Tetsu Akiyama
    • Organizer
      Long Noncoding RNAs: Marching toward Mechanism
    • Place of Presentation
      Santa Fe, New Mexico, USA
    • Year and Date
      2014-02-27 – 2014-03-04
    • Related Report
      2013 Annual Research Report
  • [Presentation] ASBEL, an ANA/BTG3 antisense transcript required for tumorigenicity of ovarian carcinoma.2013

    • Author(s)
      谷上 賢瑞、秋山 徹
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-10-03 – 2013-10-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] RNA結合タンパク質D8はc-junの転写後制御を介してAPC (Min/+)マウスにおける腫瘍形成を制御する2013

    • Author(s)
      山角 祐介、渡邊 紘介、小田 健昭、佐藤 裕美、秋山 徹
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-10-03 – 2013-10-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経膠芽腫の発症における5-hydroxymethylcytosineの役割 / Role of 5-hydroxymethylcytosine in the tumorigenicity of glioblastoma cells2013

    • Author(s)
      高井 弘基、秋山 徹
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-10-03 – 2013-10-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] The role of miR-363-GATA6-Lgr5 pathway in colorectal tumorigenesis2013

    • Author(s)
      川崎 善博、辻 真之介、古川 史織、谷上 賢瑞、林 寛敦、日吉 雅也 、北山 丈二 、秋山 徹
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-10-03 – 2013-10-05
    • Related Report
      2013 Annual Research Report
  • [Presentation] Functional analysis of a novel long ncRNA involved in the tumorigenicity of colorectal cancer.2013

    • Author(s)
      Kenzui Taniue,Akiko Kurimoto,Hironobu Sugimasa, Emiko Nasu, Takeshi Nagashima,Mariko Okada-Hatakeyama,Tetsu Akiyama
    • Organizer
      AACR
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2013-04-06 – 2013-04-10
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 延寿命制御活性を有する物質をスクリーニングする方法2013

    • Inventor(s)
      秋山徹 他3名
    • Industrial Property Rights Holder
      秋山徹 他3名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-07-24
    • Related Report
      2013 Annual Research Report

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Published: 2014-07-25   Modified: 2016-09-08  

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