• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanism of misfolded protein transportation to outside cells

Research Project

Project/Area Number 25670143
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionOsaka University

Principal Investigator

ARASE Hisashi  大阪大学, 微生物病研究所, 教授 (10261900)

Co-Investigator(Renkei-kenkyūsha) KOHYAMA Masako  大阪大学, 微生物病研究所, 助教 (70311339)
SUENAGA Tadahiro  大阪大学, 微生物病研究所, 助教 (20396675)
HIRAYASU Kouyuki  大阪大学, 免疫学フロンティア研究センター, 特任助教 (30585170)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywordsミスフォールドタンパク質 / 分子シャペロン / MHCクラスⅡ / 自己抗体 / 自己免疫疾患 / MHCクラスII
Outline of Final Research Achievements

We have identified MHC class II molecules as a molecule that transports cellular misfolded MHC class I molecules to the cell surface. When we analyzed other proteins, hen egg lysozeme, immunoglobulin heavy chain and β2-glycoprotein I were also transported to the cell surface by MHC class II molecules upon association with MHC class II molecules. Furthermore, these misfolded proteins transported to the cell surface by MHC class II molecules were found to be specific targets for autoantibodies produced in rheumatoid arthritis and antiphospholipid syndrome. In order to identify molecules that transport misfolded proteins to the cell surface, we analyzed molecules that associate with misfolded proteins at the cell surface. We found that several molecules are associated with misfolded proteins by mass spectrometry.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (63 results)

All 2015 2014 2013 Other

All Journal Article (16 results) (of which Peer Reviewed: 12 results,  Acknowledgement Compliant: 1 results,  Open Access: 3 results) Presentation (39 results) (of which Invited: 17 results) Book (4 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] β2-glycoprotein I/ HLA class II complexes are novel autoantigens in antiphospholipid syndrome.2015

    • Author(s)
      Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada H, Arase H.
    • Journal Title

      Blood

      Volume: 125 Issue: 18 Pages: 2835-2844

    • DOI

      10.1182/blood-2014-08-593624

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ミスフォールド蛋白質/MHCクラスII分子複合体による新たな自己免疫疾患発症機構2015

    • Author(s)
      荒瀬 尚
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63(2) Pages: 187-192

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Negative regulation of DSS-induced experimental colitis by PILRα.2015

    • Author(s)
      Kishida, K., Kohyama, M., Kurashima, Y., Kogure, Y., Wang, J., Hirayasu, K., Suenaga, T., Kiyono, H., Kunisawa, J. and Arase, H.
    • Journal Title

      Int. Immunol.

      Volume: - Issue: 6 Pages: 307-314

    • DOI

      10.1093/intimm/dxv004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 自己免疫疾患におけるMHC(HLA)クラスⅡ分子のあらたな機能2014

    • Author(s)
      荒瀬 尚
    • Journal Title

      週刊医学のあゆみ 「HLAのブレイクスルー ー臨床応用と疾患研究の進歩」

      Volume: 251(4) Pages: 283-288

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Engineering large viral DNA genomes using the CRISPR-Cas9 system.2014

    • Author(s)
      Suenaga T, Kohyama M, Hirayasu K, Arase H.
    • Journal Title

      Microbiol Immunol.

      Volume: 58(9) Issue: 9 Pages: 513-522

    • DOI

      10.1111/1348-0421.12180

    • NAID

      40020207309

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A motif in LILRB2 critical for Angptl2 binding and activation.2014

    • Author(s)
      Deng M, Lu Z, Zheng J, Wan X, Chen X, Hirayasu K, Sun H, Lam Y, Chen L, Wang Q, Song C, Huang N, Gao GF, Jiang Y, Arase H, Zhang CC.
    • Journal Title

      Blood.

      Volume: 124(6) Issue: 6 Pages: 924-935

    • DOI

      10.1182/blood-2014-01-549162

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自己免疫疾患の新たな発症メカニズム2014

    • Author(s)
      荒瀬 規子、金 暉、荒瀬 尚
    • Journal Title

      感染・炎症・免疫

      Volume: 44(2) Pages: 67-69

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 自己免疫疾患の新たな発症メカニズム2014

    • Author(s)
      荒瀬 規子、金 暉、荒瀬 尚
    • Journal Title

      細胞工学

      Volume: 33(7) Pages: 762-763

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRα.2014

    • Author(s)
      Kuroki K, Wang J, Ose T, Yamaguchi M, Tabata S, Maita N, Nakamura S, Kajikawa M, Kogure A, Satoh T, Arase H, Maenaka K.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111(24) Issue: 24 Pages: 8877-8882

    • DOI

      10.1073/pnas.1324105111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of immune responses by neutrophils2014

    • Author(s)
      Jing, W., Arase, H.
    • Journal Title

      Ann. N. Y. Acad. Sci.

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility2014

    • Author(s)
      Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H
    • Journal Title

      Proceedings of National Academy of Science USA

      Volume: 111 Issue: 10 Pages: 3787-3792

    • DOI

      10.1073/pnas.1401105111

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages.2014

    • Author(s)
      Haldar, M., Kohyama, M., So, A.Y., Kc, W., Wu, X., Briseno, C.G., Satpathy, A.T., Kretzer, N.M., Arase, H., Rajasekaran, N.S., Wang, L., Egawa, T., Igarashi, K., Baltimore, D., Murphy, T.L., and Murphy, K.M.
    • Journal Title

      Cell

      Volume: 156 Issue: 6 Pages: 1223-1234

    • DOI

      10.1016/j.cell.2014.01.069

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis.2013

    • Author(s)
      Minami T, Kijima T, Kohmo S, Arase H, Otani Y, Nagatomo I, Takahashi R, Miyake K, Higashiguchi M, Morimura O, Ihara S, Tsujino K, Hirata H, Inoue K, Takeda Y, Kida H, Tachibana I, Kumanogoh A.
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 2669-2669

    • DOI

      10.1038/srep02669

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Us3 kinase encoded by herpes simplex virus 1 mediates down regulation of cell surface major histocompatibility complex class Iand evasion of CD8+ T cells.2013

    • Author(s)
      Imai, T., et al.
    • Journal Title

      PLos One

      Volume: 8 Issue: 8 Pages: e72050-e72050

    • DOI

      10.1371/journal.pone.0072050

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion.2013

    • Author(s)
      Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H.
    • Journal Title

      J Virol.

      Volume: 87(19) Issue: 19 Pages: 10900-10903

    • DOI

      10.1128/jvi.01427-13

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] CD1a-positive familial cutaneous mastocytosis without germ-line or somatic mutations in c-kit2013

    • Author(s)
      Arase, N., Wataya-Kaneda, M., Oiso, N., Arase, H., Katayama, I.
    • Journal Title

      Br. J. Dermatol.

      Volume: 169 Issue: 1 Pages: 201-204

    • DOI

      10.1111/bjd.12265

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Cellular misfolded proteins rescued from protein degradation by MHC class II molecules are targets for autoantibodies in autoimmune diseases2015

    • Author(s)
      Hisashi Arase
    • Organizer
      Immunology at the Forefront, the 6th IFReC International Symposium
    • Place of Presentation
      KNOWLEDGE THEATER, Grand Front Osaka, Japan
    • Year and Date
      2015-02-23 – 2015-02-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 自己免疫疾患の新たな標的分子:ミスフォールド蛋白質/MHCクラスⅡ分子複合体2015

    • Author(s)
      荒瀬 尚
    • Organizer
      第22回自己抗体と自己免疫シンポジウム
    • Place of Presentation
      丸ビルホール(東京)
    • Year and Date
      2015-02-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Cellular misfolded proteins rescued from protein degradation by MHC class II molecules are targets for autoantibodies in autoimmune diseases2015

    • Author(s)
      Hui Jin, Lewis L. Lanier and Hisashi Arase
    • Organizer
      Keystone Symposia on Autoimmunity and Tolerance
    • Place of Presentation
      Keystone (U.S.A)
    • Year and Date
      2015-02-02 – 2015-02-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cellular misfolded proteins complexed with MHC class II molecules are targets for autoimmune diseases2015

    • Author(s)
      荒瀬 尚
    • Organizer
      第4回眉山免疫シンポジウム
    • Place of Presentation
      徳島大学(徳島)
    • Year and Date
      2015-01-29 – 2015-01-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ミスフォールド蛋白質/MHCクラスII分子複合体による新たな自己免疫疾患発症機構2015

    • Author(s)
      荒瀬 尚
    • Organizer
      千葉アレルギークリニカルカンファレンス2015
    • Place of Presentation
      オークラ千葉ホテル(千葉)
    • Year and Date
      2015-01-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Inhibition of melanogenesis by HLA class II molecules2014

    • Author(s)
      Noriko Arase, Atsushi Tanemura, You Reiri, Megumi Nishioka, Jin Hui, Hisashi Arase, Ichro Katayama
    • Organizer
      日本研究皮膚科学会 第39回年次学術大会・総会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪)
    • Year and Date
      2014-12-12 – 2014-12-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Myeloperoxidase/HLA class II complexes are targets for autoantibodies in microscopic polyangiitis.2014

    • Author(s)
      Hiwa Ryosuke, Ohmura Koichiro, Arase Noriko, Jin Hui, Hirayasu Kouyuki, Kohayama Masako, Suenaga Tadahiro, Matsuoka Sumiko, Iwatani Hirotsugu, Atsumi Tatsuya, Terao Chikashi, Mimori Tsuneyo, Arase Hisashi
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Processing of cellular misfolded protein complexed with MHC class II molecules2014

    • Author(s)
      Kishida Kazuki, Arase Hisashi
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] PILRα negatively regulates size of adipose tissue by controlling monocyte mobility2014

    • Author(s)
      Kohyama Masako, Kishida Kazuki, Arase Hisashi
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] MHC class II-restricted recognition of self-antigen/MHC class II complexes by autoantibodies2014

    • Author(s)
      Jin Hui, Arase Noriko, Matsuoka Sumiko, Hirayasu Kouyuki, Kohayama Masako, Suenaga Tadahiro, Nakamaru Yuji, Imatani Yoshinori, Katayama Ichiro, Arase Hisashi
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ペア型レセプターPILRによる糖鎖認識を介した免疫制御機構2014

    • Author(s)
      荒瀬 尚
    • Organizer
      第12回糖鎖学コンソーシアムシンポジウム
    • Place of Presentation
      千葉大学医学部記念講堂(千葉)
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ペア型レセプターを介した宿主病原体相互作用2014

    • Author(s)
      荒瀬 尚
    • Organizer
      千葉大学感染症グローバルネットワークフォーラム2014
    • Place of Presentation
      東京医科歯科大学鈴木章夫記念講堂(東京)
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] CRISPR/Cas9システムを用いた DNA ウイルスのゲノム改変2014

    • Author(s)
      末永忠広、荒瀬尚
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cellular misfolded proteins complexed with MHC class II molecules are targets for autoantibodies in autoimmune diseases2014

    • Author(s)
      Hisashi Arase
    • Organizer
      France-Japan Workshop
    • Place of Presentation
      The conference room in Cassis is l'Oustau Calendal, Cassis (France)
    • Year and Date
      2014-10-22 – 2014-10-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Paired receptors in host pathogen interaction2014

    • Author(s)
      Hisashi Arase
    • Organizer
      2014 NHRI/IBMS Joint International Conference on Inflammation & Disease
    • Place of Presentation
      Institute of Biomedical Sciences, Academia Sinica(Taiwan)
    • Year and Date
      2014-10-16 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Cellular misfolded proteins transported to the cell surface by MHC class II molecules are targets for autoantibodies2014

    • Author(s)
      荒瀬 尚
    • Organizer
      Novo Nordisk Innovation Summit 2014
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2014-10-01 – 2014-10-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Engineering of large viral DNA genomes using the CRISPR-Cas9 system2014

    • Author(s)
      Tadahiro Suenaga, Hisashi Arase
    • Organizer
      第13回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      奈良県新公会堂(奈良)
    • Year and Date
      2014-09-23 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Immune sensing system for bacterially degraded immunoglobulin via activating receptor DIR2014

    • Author(s)
      Kouyuki Hirayasu, Fumiji Saito, Hiroki Nagai, Kyoko Shida, Noriko Arase, Yasuhiko Horiguchi, Yuji Nakamaru, Ichiro Katayama, Hisashi Arase
    • Organizer
      第13回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      奈良県新公会堂(奈良)
    • Year and Date
      2014-09-23 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] ミスフォールド蛋白質/MHCクラスII分子複合体による新たな自己免疫疾患発症機構2014

    • Author(s)
      荒瀬 尚
    • Organizer
      第57回日本臨床検査医学会近畿支部総会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Year and Date
      2014-09-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Regulation of Immune Response by Paired Receptors2014

    • Author(s)
      Hisashi Arase
    • Organizer
      Taishan Academic Forum on Cancer & Immune Singnaling Pathways And First Session Stem Cell Immunology Qilu International Forum
    • Place of Presentation
      Yantai,China
    • Year and Date
      2014-08-09 – 2014-08-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Sialic Acids on N-glycosylated VZV gB are Required for Membrane Fusion Mediated by Myelin-associated Glycoprotein (MAG)2014

    • Author(s)
      Tadahiro Suenaga, Fuminori Arisawa, Maki Matsumoto, Hisashi Arase
    • Organizer
      The 39th Annual International Herpesvirus Workshop (IHW2014)
    • Place of Presentation
      Kobe International Exhibition Hall
    • Year and Date
      2014-07-19 – 2014-07-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Autoantibodies in Rheumatoid Arthritis Specifically Recognize IgG Heavy Chain Complexed with HLA-DR, Which is Strongly Associated with Rheumatoid Arthritis Susceptibility.2014

    • Author(s)
      Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H.
    • Organizer
      The 15th Annual European Congress of Rheumatology EULAR 2014
    • Place of Presentation
      Paris(France)
    • Year and Date
      2014-06-11 – 2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 病原体とペア型レセプター2014

    • Author(s)
      荒瀬 尚
    • Organizer
      第31回日本産婦人科感染症研究会 学術集会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Year and Date
      2014-06-07 – 2014-06-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] MHCクラスⅡ分子によって細胞外へ輸送された細胞内ミスフォールド蛋白質が自己抗体の標的分子である2014

    • Author(s)
      金暉、荒瀬規子、平安恒幸、香山雅子、末永忠広、松岡須美子、斉藤隆、Lewis L. Lanier、荒瀬尚
    • Organizer
      第24回Kyoto T cell Conference
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2014-05-16 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] PILRαの糖鎖認識機構と機能

    • Author(s)
      荒瀬 尚
    • Organizer
      糖鎖免疫2014
    • Place of Presentation
      東京医科歯科大学(東京)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Regulation of Immune Response by Paired Receptors

    • Author(s)
      Hisashi Arase
    • Organizer
      The 3rd NIF Winter School on Advanced Immunology
    • Place of Presentation
      Awaji (Japan)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Rheumatoid factor binding to IgG heavy chain presented on HLA-DR is associated with Rheumatoid Arthritis susceptibility

    • Author(s)
      Jin Hui, Arase Noriko, Kohayama Masako, Saito Fumiji, Hirayasu Kouyuki, Matsumoto Maki, Shida Kyoko, Suenaga Tadahiro, Saito Takashi, Katayama Ichiro, Lanier Lewis L., Arase Hisashi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2013 Research-status Report
  • [Presentation] β2-glycoprotein I presented on MHC class II molecules are recognized by autoantibodies in antiphospholipid syndrome

    • Author(s)
      Tanimura Kenji, Suenaga Tadahiro, Jin Hui, Hirayasu Kouyuki, Arase Noriko, Kohayama Masako, Ebina Yasuhiko, Yasuda Shinsuke, Horita Tetsuya, Katayama Ichiro, Atsumi Tatsuya, Yamada Hideo, Arase Hisashi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2013 Research-status Report
  • [Presentation] PILRα negatively regulates DSS induced experimental colitis

    • Author(s)
      Kishida Kazuki, Kohyama Masako, Kurashima Yosuke, Wang Jing, Hirayasu Kouyuki, Suenaga Tadahiro, Kiyono Hiroshi, Kunisawa Jun, Arase Hisashi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Thymic epithelial cell-derived exsomes are responsible for MHC class II expression on thymoyctess

    • Author(s)
      Arisawa Fuminori, Arase Hisashi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Immune sensing system for immunoglobulin degradation by bacteria

    • Author(s)
      Hirayasu Kouyuki, Saito Fumiji, Horiguchi Yasuhiko, Nagai Hiroki, Arase Hisashi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2013 Research-status Report
  • [Presentation] PILRα negatively regulates monocyte mobility

    • Author(s)
      Kohyama Masako, Wang Jing Kishida Kazuki, Arase Hisashi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Misfolded proteins complexed with MHC class II molecules are targeted by autoantibodies

    • Author(s)
      Hisashi Arase
    • Organizer
      日独免疫セミナー
    • Place of Presentation
      日本平ホテル (Japan)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 水痘帯状疱疹ウイルス(VZV)の膜融合メカニズムの解析

    • Author(s)
      末永忠広、森康子、荒瀬尚
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 病原体とペア型レセプター

    • Author(s)
      荒瀬 尚
    • Organizer
      第67回日本細菌学会東北支部総会
    • Place of Presentation
      東北大学(宮城)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] MHCクラスII分子と自己抗体

    • Author(s)
      荒瀬 尚
    • Organizer
      免疫サマースクール2013
    • Place of Presentation
      ザ・ルイガンズ(福岡)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Herpesvirus 6 Glycoprotein B (gB), gH, gL and gQ are Necessary and Sufficient for Cell-to-Cell Fusion

    • Author(s)
      Tadahiro Suenaga, Yuki Tanaka, Misako Matsumoto, Tsukasa Seya, Hisashi Arase
    • Organizer
      38th International Herpesvirus Workshop
    • Place of Presentation
      Grand Rapids, Michigan (USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] 水痘帯状疱疹ウイルス(VZV)glycoprotein H (gH)受容体の解析

    • Author(s)
      末永忠広、松本麻紀、有澤史倫、森康子、荒瀬尚
    • Organizer
      第28回ヘルペスウイルス研究会
    • Place of Presentation
      淡路夢舞台国際会議場(淡路市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Misfolded ER proteins transported to the cell surface by MHC class II molecules are targeted by autoantibodies

    • Author(s)
      Hisashi Arase
    • Organizer
      Immune Regulation by Immunoreceptors
    • Place of Presentation
      筑波大学(つくば市)
    • Related Report
      2013 Research-status Report
  • [Book] 細胞工学2013

    • Author(s)
      荒瀬 尚
    • Publisher
      秀潤社
    • Related Report
      2013 Research-status Report
  • [Book] 臨床免疫・アレルギー科2013

    • Author(s)
      王 静, 荒瀬 尚
    • Publisher
      科学評論社
    • Related Report
      2013 Research-status Report
  • [Book] 血液フロンティア2013

    • Author(s)
      荒瀬 規子, 荒瀬 尚
    • Publisher
      医薬ジャーナル社
    • Related Report
      2013 Research-status Report
  • [Book] 週刊 医学のあゆみ「免疫グロブリン様受容体による免疫制御と疾患」2013

    • Author(s)
      王 静, 荒瀬 尚
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Research-status Report
  • [Remarks] 免疫化学分野ホームページ

    • URL

      http://immchem.biken.osaka-u.ac.jp

    • Related Report
      2014 Annual Research Report
  • [Remarks] 免疫化学分野ホームページ

    • URL

      http://immchem.biken.osaka-u.ac.jp/

    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 免疫用ペプチド、それを含む免疫疾患用医薬組成物、および免疫疾患の予防または治療方法2015

    • Inventor(s)
      荒瀬 尚, 岸田 一輝
    • Industrial Property Rights Holder
      荒瀬 尚, 岸田 一輝
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-068043
    • Filing Date
      2015-03-30
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 自己抗体の検出方法、自己免疫疾患の罹患の可能性を試験する方法、自己抗体の検出試薬および自己免疫疾患用の試験試薬2013

    • Inventor(s)
      荒瀬尚, 谷村憲司, 金暉,荒瀬規子
    • Industrial Property Rights Holder
      荒瀬尚, 谷村憲司, 金暉,荒瀬規子
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-148833
    • Filing Date
      2013-07-17
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2020-03-17  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi