Elucidation of molecular mechanisms underlying cell-adhesion molecule-dependent autism spectrum disorders
| Project/Area Number |
25670149
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
HARA Yuji 京都大学, 工学(系)研究科(研究院), 准教授 (60362456)
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| Co-Investigator(Kenkyū-buntansha) |
TANABE Kenji 東京女子医科大学, 医学部, テニュアトラック准教授 (80423341)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 細胞接着因子 / 自閉症 / Neurexinファミリー / CNTNAP2 / タンパク質ラベル化法 / ジストログリカン / 細胞外マトリックス / 神経接着因子 / プロテオーム解析 |
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| Outline of Final Research Achievements |
Interactions mediated by cell adhesion molecules are important for fine-tuning of neuronal activities. It has been shown that disrupted interactions between pre- and post-synaptic cells lead to a variety of neural diseases including autism spectrum disorders. In this study we aimed to elucidate the molecular mechanisms underlying autism spectrum disorders, by means of identification interacting molecules for autism spectrum disorder-related factor CNTNAP2.
We carried out proteomic approaches by utilizing the extracellular region of CNTNAP2 as an affinity column. However, during the course of this study, other researchers identified CNTNAP2-interacting molecules by complehensive proteomic approaches. Thus we decided to also focus on other cell-cell adhesion molecules such as CNTNAP4 that is involved in synaptic transmission in mice.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Dominant mutations in ORAI1 cause tubular-aggregate-myopathy with hypocalcemia by constitutive activation of store-operated Ca2+ channel2014
Author(s)
Endo Y, Noguchi S, Hara Y, Hayashi YK, Motomura K, Murakami N, Tanaka S, Yamashita S, Kizu R, Bamba M, Goto Y, Matsumoto N, Nonaka I, Nishino I.
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Journal Title
Hum Mol Genet
Volume: 24（3）
Issue: 3
Pages: 637-648
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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