| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Sphingosine 1-phosphate (S1P) is combined with a sphingosine 1-phosphate receptor (S1PR) emerging in the cell surface and shows bioactivity. Five subtypes of S1PR have been identified so far, and these are tissue-specific. Recently, it has been revealed that S1PR affected the malignant transformation of cancer deeply, and the positioning as the tumor marker became important. Therefore I used high polymer material called " RNA" with the artificial ligand which could be specifically combined with each subtype of S1PR and tried that it produced wounds. However, I succeeded in the construction of the S1PR surface presentation cell and tried whole Cell SELEX, but dominant RNA aptamer was not provided.
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