The neural circuits underlying the pathophysiologies of schizophrenia

• Project/Area Number: 25670154
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Research Institute, Shiga Medical Center
• Principal Investigator: TANIGAKI Kenji 滋賀県立成人病センター(研究所), その他部局等, 専門研究員 (70362473)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 統合失調症 / 神経回路網 / 22q11欠損症候群 / copy number variation / Cre / 動物モデル / レンチウイルス / 22q11

Outline of Final Research Achievements

22q11 deletion syndrome is a chromosome disorder. 20-30% of the patients with this disorder develop schizophrenia. 22q11-deleted region is conserved in mouse cromosome16, which facilitated a mouse model of 22q11 deletion syndrome. We performed neurodevelopmental analysis of this model mice, and found developmental abnormalities in the hippocampal dentate gyrus and the cortical interneurons. Our data demonstrated that these developmental abnormalities are caused by hemizygous deletion of Dgcr8, one of the genes in the 22q11-deleted region.

Research Products

• [Journal Article] Neuronal migration abnormalities and its possible implications for schizophrenia. (2015)
  • Author(s): Kazue Muraki, Kenji Tanigaki
  • Journal Title: Front Neurosci. Volume: 9 Pages: 74-74
  • DOI: 10.3389/fnins.2015.00074
  • Peer Reviewed / Open Access
• [Journal Article] 遺伝子研究と統合失調症 (2014)
  • Author(s): 谷垣健二
  • Journal Title: 精神科 Volume: 25 Pages: 593-597
  • Peer Reviewed
• [Journal Article] Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. (2013)
  • Author(s): Toritsuka M, Kimoto S, Muraki K, Landek-Salgado MA, Yoshida A, Yamamoto N, Horiuchi Y, Hiyama H, Tajinda K, Keni N, Illingworth E, Iwamoto T, Kishimoto T, Sawa A, Tanigaki K.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 110 Issue: 43 Pages: 17552-17557
  • DOI: 10.1073/pnas.1312661110
  • Peer Reviewed
• [Presentation] Comt-mediated regulation of GABAergic system in a 22q11 deletion syndrome model mice. (2014)
  • Author(s): 谷垣健二
  • Organizer: 日本神経化学会
  • Place of Presentation: 奈良
  • Year and Date: 2014-10-01
  • Invited
• [Presentation] 統合失調症とCxcr4/Cxcl12 シグナルの関与 (2014)
  • Author(s): 谷垣健二
  • Organizer: 第9回統合失調症学会
  • Place of Presentation: 京都
• [Presentation] Molecular mechanisms underlying schizophrenia-like phenotypes of 22q11 model mice (2013)
  • Author(s): Kenji Tanigaki
  • Organizer: 11th world congress of biological psychiatry
  • Place of Presentation: 京都
  • Invited
• [Presentation] Neuropathological analysis of 22q11.2 deletion syndrome model mice. (2013)
  • Author(s): Kenji Tanigaki
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
• [Remarks] 滋賀県立成人病センター 研究所
  • URL: http://www.shigamed.jp/index.html