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The neural circuits underlying the pathophysiologies of schizophrenia

Research Project

Project/Area Number 25670154
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionResearch Institute, Shiga Medical Center

Principal Investigator

TANIGAKI Kenji  滋賀県立成人病センター(研究所), その他部局等, 専門研究員 (70362473)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords統合失調症 / 神経回路網 / 22q11欠損症候群 / copy number variation / Cre / 動物モデル / レンチウイルス / 22q11
Outline of Final Research Achievements

22q11 deletion syndrome is a chromosome disorder. 20-30% of the patients with this disorder develop schizophrenia. 22q11-deleted region is conserved in mouse cromosome16, which facilitated a mouse model of 22q11 deletion syndrome. We performed neurodevelopmental analysis of this model mice, and found developmental abnormalities in the hippocampal dentate gyrus and the cortical interneurons. Our data demonstrated that these developmental abnormalities are caused by hemizygous deletion of Dgcr8, one of the genes in the 22q11-deleted region.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (4 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Neuronal migration abnormalities and its possible implications for schizophrenia.2015

    • Author(s)
      Kazue Muraki, Kenji Tanigaki
    • Journal Title

      Front Neurosci.

      Volume: 9 Pages: 74-74

    • DOI

      10.3389/fnins.2015.00074

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 遺伝子研究と統合失調症2014

    • Author(s)
      谷垣健二
    • Journal Title

      精神科

      Volume: 25 Pages: 593-597

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model.2013

    • Author(s)
      Toritsuka M, Kimoto S, Muraki K, Landek-Salgado MA, Yoshida A, Yamamoto N, Horiuchi Y, Hiyama H, Tajinda K, Keni N, Illingworth E, Iwamoto T, Kishimoto T, Sawa A, Tanigaki K.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 110 Issue: 43 Pages: 17552-17557

    • DOI

      10.1073/pnas.1312661110

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Comt-mediated regulation of GABAergic system in a 22q11 deletion syndrome model mice.2014

    • Author(s)
      谷垣健二
    • Organizer
      日本神経化学会
    • Place of Presentation
      奈良
    • Year and Date
      2014-10-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 統合失調症とCxcr4/Cxcl12 シグナルの関与2014

    • Author(s)
      谷垣健二
    • Organizer
      第9回統合失調症学会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] Molecular mechanisms underlying schizophrenia-like phenotypes of 22q11 model mice2013

    • Author(s)
      Kenji Tanigaki
    • Organizer
      11th world congress of biological psychiatry
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Neuropathological analysis of 22q11.2 deletion syndrome model mice.2013

    • Author(s)
      Kenji Tanigaki
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Remarks] 滋賀県立成人病センター 研究所

    • URL

      http://www.shigamed.jp/index.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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