Control of vascular barrier integrity by MTM family of phosphatidylinositol 3-phosphate phosphatase
| Project/Area Number |
25670162
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
TAKUWA Yoh 金沢大学, 医学系, 教授 (60171592)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIOKA Kazuaki 金沢大学, 医学系, 助教 (80333368)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ホスホイノシチド / ホスファターゼ / PI3-キナーゼ / 小胞 / 血管 / 内皮 / イノシトールリン脂質 / PI3キナーゼ / フォスファターゼ |
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| Outline of Final Research Achievements |
We studied phosphatidylinositol 3-phosphate (PI-3-P) phosphatase in vascular endothelial cells. Among 14 isoforms of MTM family members, we identified one isoform which was relatively abundantly expressed in endothelial cells. Fluorescent imaging showed the expression of GFP-tagged phosphatase in endosomes. The phosphatase negatively regulated cellular PI-3-P level and was involved in the regulation of endosomal movement. The PI-3-P phosphatase controlled migration, cell-cell adhesion and morphogenesis of endothelial cells through regulating PI-3-P level.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.2014
Author(s)
Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
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Journal Title
Diabetologia
Volume: 57
Issue: 9
Pages: 1968-1976
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells2014
Author(s)
Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, TakuwaY, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I.
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Journal Title
Pharmacology Research & Perspectives
Volume: 2
Issue: 5
Pages: 68-68
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] CCL2/CCR2 augments the production of transforming growth factor-beta1, type 1 collagen and CCL2 by human CD45-/collagen 1-positive cells under high glucose concentrations.2013
Author(s)
Hara A, Sakai N, Furuichi K, Sakai Y, Takeya M, Bucala R, Mukaida N, Takuwa Y, Matsushima K, Kaneko S, Wada T.
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Journal Title
Clin Exp Nephrol.
Volume: 17
Issue: 6
Pages: 793-804
DOI
Related Report
Peer Reviewed
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