Regulatory mechanisms of cancer soontaneous regression

• Project/Area Number: 25670163
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Nagoya University
• Principal Investigator: KADOMATSU Kenji 名古屋大学, 医学(系)研究科(研究院), 教授 (80204519)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 自然退縮 / がん / 神経芽腫

Outline of Final Research Achievements

Spontaneous regression is an intriguing phenomenon which is linked to the development of therapy of cancers. We found spontaneous regression in the neuroblastoma model MYCN Tg mice.
In this study, we could culture spheres from all specimen at early cancer stage, i.e., 2 weeks after birth. Furthermore, we succeeded sphere culture of embryonic sympathetic ganglia of MYCN Tg mice. Using these samples, we should be able to perform analyses at genome, epigenome and transcriptome levels, which may in turn lead to elucidation of mechanisms underlying cancer development and spontaneous regression.

Research Products

• [Journal Article] Atelocollagen-Mediated Intravenous siRNA Delivery Specific to Tumor Tissues Orthotopically Xenografted in Prostates of Nude Mice and Its Anticancer Effects. (2015)
  • Author(s): Yuan Y, Makita N, Cao D, Mihara K, Kadomatsu K, Takei Y.
  • Journal Title: Nucleic Acid Ther. Volume: 25 Issue: 2 Pages: 85-94
  • DOI: 10.1089/nat.2014.0526
  • Peer Reviewed
• [Journal Article] NeuroD1 promotes neuroblastoma cell growth by inducing the expression of ALK. (2015)
  • Author(s): Lu F, Kishida S, Mu P, Huang P, Cao D, Tsubota S, Kadomatsu K.
  • Journal Title: Cancer Science Volume: in press Issue: 4 Pages: 390-396
  • DOI: 10.1111/cas.12628
  • Peer Reviewed
• [Journal Article] EML4 promotes the loading of NUDC to the spindle for mitotic progression. (2015)
  • Author(s): Chen D, Ito S, Yuan H, Hyodo T, Kadomatsu K, Hamaguchi M, Senga T.
  • Journal Title: Cell Cycle. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] The nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation. (2015)
  • Author(s): Nakaguro M, Kiyonari S, Kishida S, Cao D, Murakami-Tonami Y, Ichikawa H, Takeuchi I, Nakamura S, Kadomatsu K
  • Journal Title: Cancer Science Volume: 106 Issue: 3 Pages: 237-243
  • DOI: 10.1111/cas.12598
  • Peer Reviewed / Open Access
• [Journal Article] Neuroblastoma models for insights into tumorigenesis and new therapies. (2015)
  • Author(s): Kiyonari S, Kadomatsu K.
  • Journal Title: Expert Opin Drug Discov. Volume: 10 Issue: 1 Pages: 53-62
  • DOI: 10.1517/17460441.2015.974544
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. (2014)
  • Author(s): Murakami-Tonami Y, Kishida S, Takeuchi I, Katou Y, Maris JM, Ichikawa H, Kondo Y, Sekido Y, Shirahige K, Murakami H, Kadomatsu K.
  • Journal Title: Cell Cycle. Volume: 13 Issue: 7 Pages: 1115-1131
  • DOI: 10.4161/cc.27983
  • Peer Reviewed / Open Access
• [Journal Article] A new tumorsphere culture condition restores potentials of self-renewal and metastasis of primary neuroblastoma in a mouse neuroblastoma model. (2014)
  • Author(s): Cao D, Kishida S, Huang P, Mu P, Tsubota S, Mizuno M, Kadomatsu K.
  • Journal Title: PLoS One. Volume: 9
  • Peer Reviewed
• [Journal Article] Midkine : an emerging target of drug development for treatment of multiple diseases (2014)
  • Author(s): Muramatsu T, Kadomatsu K
  • Journal Title: Br J Pharmacol Volume: 171(4) Issue: 4 Pages: 811-813
  • DOI: 10.1111/bph.12571
  • Peer Reviewed
• [Journal Article] Therapeutic potential of midkine in cardiovascular disease (2014)
  • Author(s): Kadomatsu K, Bencsik P, Görbe A, Csonka C, Sakamoto K, Kishida S, Ferdinandy P
  • Journal Title: Br J Pharmacol Volume: 171(4) Issue: 4 Pages: 936-944
  • DOI: 10.1111/bph.12537
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of midkine in neuroblastoma tumourigenesis (2014)
  • Author(s): Kishida S, Kadomatsu K
  • Journal Title: Br J Pharmacol Volume: 171(4) Issue: 4 Pages: 896-904
  • DOI: 10.1111/bph.12442
  • Peer Reviewed
• [Journal Article] Expression of midkine in normal human skin, dermatitis and neoplasms: association with differentiation of keratinocytes. (2013)
  • Author(s): Monma F, Hozumi Y, Ikematsu S, Kawaguchi M, Kadomatsu K, Suzuki T.
  • Journal Title: J Dermatol. Volume: 40 Issue: 12 Pages: 980-986
  • DOI: 10.1111/1346-8138.12333
  • Peer Reviewed
• [Journal Article] Discovering combinatorial interactions in survival data (2013)
  • Author(s): David duVerle, Ichiro Takeuchi, Yuko Murakami-Tonami, Kenji kadomatsu, Koji Tsuda
  • Journal Title: Bio in formatics Volume: 23 Issue: 23 Pages: 3053-3059
  • DOI: 10.1093/bioinformatics/btt532
  • Peer Reviewed
• [Journal Article] Midkine overcomes neurite outgrowth inhibition of chondroitin sulfate proteoglycan without glial activation and promotes functional recovery after spinal cord injury. (2013)
  • Author(s): Muramoto A, Imagama S, Natori T, Wakao N, Ando K, Tauchi R, Hirano K, Shinjo R, Matsumoto T, Ishiguro N, Kadomatsu K.
  • Journal Title: Neurosci Lett. Volume: 550 Pages: 150-155
  • DOI: 10.1016/j.neulet.2013.06.025
  • Peer Reviewed
• [Journal Article] The heparin-binding growth factor midkine : the biological activities and candidate receptors (2013)
  • Author(s): Kadomatsu K, Kishida S, Tsubota S
  • Journal Title: J Biochem Volume: 153(6) Issue: 6 Pages: 511-521
  • DOI: 10.1093/jb/mvt035
  • NAID: 40019655639
  • Peer Reviewed
• [Presentation] Biomedical research at Nagoya University: International joint symposium Nagoya University
  • Author(s): Kadomatsu, K.
  • Organizer: University of Adelaide, University of Freiburg,
  • Place of Presentation: Nagoya University, Nagoya
  • Invited
• [Presentation] 糖鎖と神経の融合研究へ ～硫酸化糖鎖と神経回路再編～
  • Author(s): 門松健治
  • Organizer: 生化学会大会シンポジウム「脳神経回路の可塑性の生化学研究：分子メカニズムから疾患まで
  • Place of Presentation: 横浜国際会議場、横浜
  • Invited
• [Book] Sugar Chains (2015)
  • Author(s): Kishida S, Kadomatsu K.
  • Total Pages: 288
  • Publisher: Springer
• [Remarks] 名古屋大学大学院医学系研究科分子生物学
  • URL: http://www.med.nagoya-u.ac.jp/biochem/
• [Remarks] 名古屋大学大学院医学系研究科分子生物学
  • URL: http://www.med.nagoya-u.ac.jp/biochem