| Project/Area Number |
25670182
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
Toyoda Masashi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (50392486)
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| Research Collaborator |
SASAKI Norihiko
ITAKURA Yoko
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ヒト幹細胞 / 糖タンパク質 / 糖脂質 / 老化 / 再生 / 糖鎖 / 細胞老化 / 幹細胞 / 組織環境 / 再生医学 / 移植・再生医療 |
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| Outline of Final Research Achievements |
The cell surface is covered with various glycans, which play a crucial role in biological function. The cell surface dynamics changes of glyccans regulate cellular function during development, differentiation and survival. We investigated glycan changes of the cellular senescence process on human fibroblast, vascular endothelial cells and mesenchymal stem cells with cellular senescence process and/or human aging. The glycan profile of cell surface glycoprotein on cellular senescence process and/or human aging had been significantly changed in fibroblast and mesenchymal stem cells. Thus it was easy to speculate that cellular senescence process was concerned with the change of glycan component of cell surface. Also, we reveal that ganglioside GM1 increase on cell surface vascular endothelial cells accompanying with cellular senescence process and human aging, and that the increased GM1 cause a state of insulin resistance in senescent vascular endothelial cells.
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