| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We revealed that a small G protein we identified play a role for type 1 Interferon expression via TLR7 activation. Because it is reported that both TLR7 and type 1 Interferon are related to Systemic Lupus Erythematosus (SLE). We analyzed small G protein deficient SLE model mice, MRL-lpr. As a result, they could not be found the onset of SLE. This result is more significantly inhibited than TLR7 deficient or type 1 interferon receptor deficient MRL-lpr mice. These results indicate that small G protein we identified has an important role for the onset of SLE.
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