Identification of an internal TLR7 ligand related to the onset of Systemic Lupus Erythematosus
Project/Area Number |
25670189
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 全身性エリトマトーデス / Toll-like receptor 7 / pristane / 内在性リガンド / SLEモデルマウス / TLR7 / 自己免疫疾患 / 1型インターフェロン / 形質細胞用樹状細胞 / RNA / 免疫 |
Outline of Final Research Achievements |
We revealed that a small G protein we identified play a role for type 1 Interferon expression via TLR7 activation. Because it is reported that both TLR7 and type 1 Interferon are related to Systemic Lupus Erythematosus (SLE). We analyzed small G protein deficient SLE model mice, MRL-lpr. As a result, they could not be found the onset of SLE. This result is more significantly inhibited than TLR7 deficient or type 1 interferon receptor deficient MRL-lpr mice. These results indicate that small G protein we identified has an important role for the onset of SLE.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases2015
Author(s)
Kanno A, Tanimura N, Ishizaki M, Ohko K, Motoi Y, Onji M, Fukui R, Shimozato T, Yamamoto K, Shibata T, Sano S, Sugahara-Tobinai A, Takai T, Ohto U, Shimizu T, Saitoh S, Miyake K.
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Journal Title
Nature Communications
Volume: 6
Issue: 1
Pages: 6119-6119
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing2013
Author(s)
Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K
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Journal Title
Nat. Commun.
Volume: 4
Issue: 1
Pages: 1949-1949
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in intramolecular disulfide bond, proteolytic cleavage, and RNA-sensing2013
Author(s)
Kanno A, Yamamoto C, Onji M, Fukui R, Saitoh SI, Motoi Y, Shibata T, Matsumoto F, Muta T, Miyake K
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Journal Title
Int Immunol.
Volume: 25
Issue: 7
Pages: 413-422
DOI
Related Report
Peer Reviewed
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