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IL-1beta production depending on size of insoluble material generated in vivo

Research Project

Project/Area Number 25670192
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionKyoto University

Principal Investigator

INABA Kayo  京都大学, 生命科学研究科, 教授 (00115792)

Co-Investigator(Kenkyū-buntansha) TAKAHARA Kazuhiko  京都大学, 大学院生命科学研究科, 講師 (90301233)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords微細粒子 / IL-1β / アミロイド β / 炎症 / 凝集体 / マイクログリア / アミロイド-b / 原子間力顕微鏡 / IL-1beta / アミロイド-beta / 尿酸結晶
Outline of Final Research Achievements

Small particles/aggregates are known to provoke inflammatory response of macrophages (Mφ). In this study, latex beads (LxB) of 1000 nm and 20 nm, but not 100 nm in diameter, were shown to induce IL-1β production of Mφ-like microglia in the brain. Although aggregates of amyloid β (Aβ) are believed as causative agent of Alzheimer disease, only nano-sized Aβ oligomers, but not large Aβ fibril, stimulated IL-1β production of MG. In addition, the induction of IL-1β by nano-sized Aβ oligomers was dependent on reactive oxygen species (ROS) and protease cathepsin B. These results suggest that size/form of small particles/aggregates affects IL-1β production of MG.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report

Research Products

(7 results)

All 2015 2014 2013 Other

All Journal Article Presentation Remarks

  • [Journal Article] Amyloid β oligomers induce interleukin-1β production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner2015

    • Author(s)
      Taneo, J., Adachi, T., Yoshida, A., Takeyasu, K.,Takahara, K. and Inaba, K.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 458 Pages: 561-567

    • DOI
      10.1016/j.bbrc.2015.02.006
    • NAID
      120005575184
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Functional Evaluation of Activation-dependent Alteration of Sialoglycans in T Cells2014

    • Author(s)
      Naito-Matsui Y, Takada S, Kano Y, Iyoda T, Sugai M, Shimizu A, Inaba K, Nitschke L, Tsubata T, Oka S, Kozutsumi Y, and Takematsu H.
    • Journal Title

      J.Bio.Chem.

      Volume: 289 Pages: 1564-1579

    • DOI
      10.1074/jbc.m113.523753
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tracking and quantification of dendritic cell migration and antigen trafficking between the skin and lymph nodes2014

    • Author(s)
      Tomura M, Hata A, Matsuoka S, Shand FH, Nakanishi Y, Ikebuchi R, Ueha S, Tsutsui H, Inaba K, Matsushima K, Miyawaki A, Kabashima K, Watanabe T, Kanagawa O.
    • Journal Title

      Scientific Reports

      Volume: 4 Pages: 1-11

    • DOI
      10.1038/srep06030
    • NAID
      120005749847
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Particle size of latex beads dictates IL-1β production mechanism2013

    • Author(s)
      Adachi, T., Takahara, K., Taneo, J., Uchiyama, Y. and Inaba, K.
    • Journal Title

      Plos One

      Volume: 8

    • DOI
      10.1371/journal.pone.0068499
    • NAID
      120005307064
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Amyloid b oligomers, but not fibrils, induced IL-1b production by mouse microglia2013

    • Author(s)
      Takumi Adachi, Kazuhiko Takahara, Jun Taneo and Kayo Inaba
    • Organizer
      日本免疫学会
    • Place of Presentation
      千葉、幕張
    • Related Report
      2013 Research-status Report
  • [Remarks] 京都大学生命科学研究科高次生命科学専攻体制統御学講座生体応答学分野

    • URL
      http://zoo.zool.kyoto-u.ac.jp/imm/
    • Related Report
      2014 Annual Research Report
  • [Remarks] 京都大学生命科学研究科高次生命科学専攻生体応答学分野ホームページ

    • URL
      http://zoo.zool.kyoto-u.ac.jp/imm/
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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