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Establishment of basic research system of bacterial infections in common marmoset

Research Project

Project/Area Number 25670207
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Bacteriology (including mycology)
Research InstitutionHirosaki University

Principal Investigator

NAKANE AKIO  弘前大学, 医学(系)研究科(研究院), 教授 (30164239)

Co-Investigator(Renkei-kenkyūsha) NARITA KOUJI  弘前大学, 医学(系)研究科(研究院), 助教 (30419220)
ONO HISAYA  弘前大学, 医学(系)研究科(研究院), 助教 (80704569)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords感染症 / 霊長類 / 毒素 / 細菌 / 嘔吐 / 下痢 / 肥満細胞 / セロトニン
Outline of Final Research Achievements

Experimental animals including mice and rats are usually used in research on medical science. However, we should recognize that experimental data from these animals may disparate in humans. We investigated availability of a small rodent, common marmoset, in research on bacterial infections containing toxins produced from Staphylococcus aureus.
Oral administration of staphylococcal enterotoxins (SEs) induced emesis in common marmosets. Moreover, we found that SEs induced diarrhea and other staphylococcal toxins can induce emesis in common marmosets. Therefore, common marmoset is a useful animal model for research on bacterial infections.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014 Other

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Goblet cells are involved in translocation of staphylococcal enterotoxin A in the intestinal tissue of house musk shrew (Suncs murinus)2016

    • Author(s)
      Hirose S, Ono HK, Omoe K, Hu DL, Asano K, Yamamoto Y, Nakane A
    • Journal Title

      Journal of Applied Microbiology

      Volume: 120 Issue: 3 Pages: 781-789

    • DOI

      10.1111/jam.13029

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification and characterization of a novel staphylococcal emetic toxin2015

    • Author(s)
      Ono HK, Sato'o Y, Narita K, Naito I, Hirose S, Hisatsune J, Asano K, Hu DL, Omoe K, Sugai M, Nakane A.
    • Journal Title

      Appl Environ Microbiol

      Volume: 81 Issue: 20 Pages: 7034-7040

    • DOI

      10.1128/aem.01873-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adipose tissue-derived mesenchymal stem cells attenuate staphylococcal enterotoxin A-induced toxic shock2015

    • Author(s)
      Asano K, Yoshimura S, Nakane A
    • Journal Title

      Infection and Immunity

      Volume: 83 Pages: 3490-3496

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vaccination with non-toxic mutant toxic shock syndrome toxin-1 induces IL-17-dependent protection against Staphylococcus aureus infection2015

    • Author(s)
      Narita K, Hu DL, Asano K, Nakane A.
    • Journal Title

      Pathog Dis

      Volume: 73 Issue: 4

    • DOI

      10.1093/femspd/ftv023

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Establishment of new emetic animal model using common marmoset and analysis of the emesis induced by staphylococcal enterotoxin2016

    • Author(s)
      Ono HK, Hirose S, Nakane A
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府、大阪市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Characterization of superantigenic activity and stability of novel staphylococcal emetic toxin2015

    • Author(s)
      Ono HK, Nakane A
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      長良川国際会議場、岐阜県岐阜市
    • Year and Date
      2015-03-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Identification and characterization of a novel staphylococcal emetic toxin encoded in Staphylococcus aureus core genome2014

    • Author(s)
      Ono HK, Sato’o Y, Naito I, Hisatsune J, Omoe K, Sugai M, Nakane A
    • Organizer
      ISSSI 14, International Symposium on Staphylococci & Staphylococcal Infections
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-08-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 黄色ブドウ球菌ゲノム中に存在する新規嘔吐毒の生物活性2014

    • Author(s)
      小野久弥、佐藤祐介、久恒順三、菅井基行、重茂克彦、中根明夫
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀、東京
    • Related Report
      2013 Research-status Report
  • [Remarks] 弘前大学大学院医学研究科感染生体防御学講座

    • URL

      http://www.med.hirosaki-u.ac.jp/~mai/

    • Related Report
      2015 Annual Research Report 2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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