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Development of new targeting-type adjuvant molecule derived from bacteria

Research Project

Project/Area Number 25670209
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Bacteriology (including mycology)
Research InstitutionThe University of Tokyo

Principal Investigator

MIMURO Hitomi  東京大学, 医科学研究所, 准教授 (80396887)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords細菌 / ヘリコバクターピロリ / ワクチン
Outline of Final Research Achievements

The purpose of the project is to identify molecules of Helicobacter pylori that are responsible for an adjuvanticity on gut-associated lymphoid tissues (GALT), and to consider the possibility as new GALT-targeting adjuvant molecules. We have performed shotgun LC-MS/MS proteomics analysis of proteins from Peyer’s patches-transmissive and non-transmissive bacterial outer membranes, and identified the candidate molecules. We have successfully selected the candidate of high importance by bioinformatics method, and produced deletion mutant strains of the factors. The in vitro and in vivo analysis of the deletion mutants revealed that the factors have potential to regulate ability of targeting Peyer’s patches.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2014 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 3 results)

  • [Journal Article] The Immune Receptor NOD1 and Kinase RIP2 Interact with Bacterial Peptidoglycan on Early Endosomes to Promote Autophagy and Inflammatory Signaling2014

    • Author(s)
      Irving AT, Mimuro H, Kufer TA, Lo C, Wheeler R, Turner LJ, Thomas BJ, Malosse C, Gantier MP, Casillas LN, Votta BJ, Bertin J, Boneca IG, Sasakawa C, Philpott DJ, Ferrero RL, Kaparakis-Liaskos M
    • Journal Title

      Cell Host Microbe

      Volume: 15 Issue: 5 Pages: 623-635

    • DOI

      10.1016/j.chom.2014.04.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection2014

    • Author(s)
      Kiga K et.al
    • Journal Title

      Nat Commun

      Volume: 5 Issue: 1 Pages: 4497-4497

    • DOI

      10.1038/ncomms5497

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Helicobacter pyloriの感染戦略2014

    • Author(s)
      三室仁美
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ヘリコバクターピロリ感染による宿主応答制御

    • Author(s)
      三室仁美
    • Organizer
      第19回日本ヘリコバクター学会学術集会
    • Place of Presentation
      長崎
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ヘリコバクターピロリ感染による宿主応答制御

    • Author(s)
      三室仁美
    • Organizer
      平成25年度遺伝子病制御研究所国際研究集会「Infection, Immunity, Inflammation, Cancer」
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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