Host defense against bacterial infection in Notch/IL-7Ralpha axis and CD30L dependent manner.
| Project/Area Number |
25670213
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | NOTCH / Bcl11b / IL-7R / IL-17A / IFN-γ / γδT細胞 / CD30L / CD30 / 細菌学 / T細胞 / 免疫学 / γδ細胞 / 細菌感染 |
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| Outline of Final Research Achievements |
Early T cell precursors at the double-negative (DN) 2 or 3 stages in fetal thymus are committed to IL-17A or IFN-γ γδ T cells.We found that IL-17A γδ T cells developed directly from DN2b cells in Notch/Hes1, Notch/Bcl11b and Notch/IL-7Rα-dependent pathways, whereas two types of IFN-γ γδ T cells developed from DN2a or DN3 stage in fetal thymus, respectively. CD30 and CD30L were selectively expressed by IL-17A γδ T cells and the number was drastically reduced in CD30L or CD30 knock out mice. In vivo administration of soluble CD30 protein (CD30-Ig) impaired the early protection against Listeria monocytogenes or Mycobacterium bovis Bacillus Calmette-Guerin infection,while agonistic anti-CD30 monoclonal antibody enhanced the protection by activating the IL-17A γδ T cells. CD30L/CD30 signaling plays an important role in the activation of IL-17A γδ T cells at the early stage for protection against bacterial infection.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] CD30 ligand is a new therapeutic target for central nervous system autoimmunity.2015
Author(s)
Shinoda K., Sun X., Oyamada A., Yamada H., Muta H., Podack E.R., Kira J., and Yoshikai Y.Shinoda K., Sun X., Oyamada A., Yamada H., Muta H., Podack E.R., Kira J., and Yoshikai Y.
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Journal Title
J.Autoimmunity
Volume: 57
Pages: 14-23
Related Report
Peer Reviewed
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[Journal Article] C-type lectin MCL is an FcR-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.2013
Author(s)
Miyake Y, Toyonaga K, Mori D., Kakuta S., Hoshino Y., Oyamada A., amada H., Ono K., Suyama M., Iwakura Y., Yoshikai Y. and Yamasaki.S
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Journal Title
Immunity
Volume: 38
Pages: 1050-1060
Related Report
Peer Reviewed
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