| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Post-translational modification of histones strongly affects chromatin functions and participates in the epigenetic regulation of the cell functions in eukaryotic cells. While bacteria produce the nucleoid-associated proteins, called histone-like proteins (HLP), but post-translational modification of HLP is hardly observed. Mycobacterium tuberculosis is a major human pathogen and kills over million people every year. This pathogen produces unique HLP, called MDP1 that is essential and controls expression of many sets of genes, and participates in regulation of mycobacterial growth and virulence. Interestingly post-translational modification occurs on MDP1, suggesting the possibility of post-translational modification-dependent control of MDP1 functions. In this research we analyzed the enzymes responsible for the modification of MDP1 in order to know the modification-dependent regulation of gene expression and epigenetic control in bacteria.
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