Possibility of epigenetic regulation in bacteria through the post-translational modification of a histone-like protein
Project/Area Number |
25670214
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Bacteriology (including mycology)
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Research Institution | Niigata University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | エピジェネティクス / ヒストン / 細菌 / 結核 / 修飾 / 抗酸菌 / MDP1 / 染色体 / 翻訳後修飾 / 遺伝子発現 |
Outline of Final Research Achievements |
Post-translational modification of histones strongly affects chromatin functions and participates in the epigenetic regulation of the cell functions in eukaryotic cells. While bacteria produce the nucleoid-associated proteins, called histone-like proteins (HLP), but post-translational modification of HLP is hardly observed. Mycobacterium tuberculosis is a major human pathogen and kills over million people every year. This pathogen produces unique HLP, called MDP1 that is essential and controls expression of many sets of genes, and participates in regulation of mycobacterial growth and virulence. Interestingly post-translational modification occurs on MDP1, suggesting the possibility of post-translational modification-dependent control of MDP1 functions. In this research we analyzed the enzymes responsible for the modification of MDP1 in order to know the modification-dependent regulation of gene expression and epigenetic control in bacteria.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Evaluation of Humoral Immunity to Mycobacterium tuberculosis-Specific Antigens for Correlation with Clinical Status and Effective Vaccine Development.2015
Author(s)
Niki, M., M. Suzukawa, S. Akashi, H. Nagai, K. Ohta, M. Inoue, M. Niki, Y. Kaneko, K. Morimoto, A. Kurashima, S. Kitada, S. Matsumoto, K. Suzuki, and Y. Hoshino
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Peer Reviewed
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[Journal Article] A New Screen for Tuberculosis Drug Candidates Utilizing a Luciferase-Expressing Recombinant Mycobacterium bovis Bacillus Calmette-Gueren2015
Author(s)
Ozeki, Y., M. Igarashi, M. Doe, A. Tamaru, N. Kinoshita, Y. Ogura, T. Iwamoto, R. Sawa, M. Umekita, S. Enany, Y. Nishiuchi, M. Osada-Oka, T. Hayashi, M. Niki, Y. Tateishi, M. Hatano, and S. Matsumoto*
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Peer Reviewed
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[Presentation] シフェラーゼ発現リコンビナントBCGによる新規結核薬の迅速スクリーニング系の確立と実践2016
Author(s)
尾関 百合子, 山口 雄大, Shymaa Enany, 五十嵐 雅之, 西内 由紀子, 岡 真優子, 岩本 朋忠, 小椋 義俊, 林 哲也, 立石 善隆, 西山 晃史, 松本 壮吉
Organizer
日本細菌学会総会
Place of Presentation
大阪国際交流センター(大阪市天王寺区)
Year and Date
2016-03-23
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[Presentation] 潜在期結核菌抗原の精製と感染診断への応用2016
Author(s)
西田 由貴子, 北所 健悟, 尾関 百合子, 立石 善隆, 井上 学, 仁木 満美子, 金子 幸弘, 松本 壮吉
Organizer
日本細菌学会総会
Place of Presentation
大阪国際交流センター(大阪市天王寺区)
Year and Date
2016-03-23
Related Report
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