• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Origin and evolution of the adaptive immune system

Research Project

Project/Area Number 25670229
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionUniversity of Fukui (2015)
The University of Tokyo (2013-2014)

Principal Investigator

Nishizumi Hirofumi  福井大学, 医学部, 准教授 (30292832)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords無顎類 / 抗原受容体 / VLR / 自己抗体 / アロ白血球抗原 / MHC / 獲得免疫 / 進化
Outline of Final Research Achievements

All vertebrates possess adaptive immune systems that can detect and inactivate non-self-antigens through a vast repertoire of antigen receptors. Unlike jawed vertebrates, the hagfish utilizes variable lymphocyte receptors (VLRs) that are unrelated to immunoglobulin molecules but are diversified by copy-choice gene conversion mechanism. Here, we report that hagfish VLRs react with allogenic leukocyte antigens but not with self-antigens. We found that a highly polymorphic membrane protein, NICIR3, is recognized by VLRs as an allogenic leukocyte antigen (ALA). In a serological cross-reactivity test, a close correlation was observed between the amino acid differences in the protein sequences and the VLR cross-reactivities. This leukocyte antigen was predominantly expressed in phagocytic leukocytes, where it was associated with phagocytosed protein antigens. These findings suggest that a polymorphic leukocyte antigen, NICIR3/ALA, plays a pivotal role in jawless vertebrate adaptive immunity.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Developmental regulation of neural map formation in the mouse olfactory system2015

    • Author(s)
      Nishizumi, H, and Sakano, H
    • Journal Title

      Dev. Neurobiol.

      Volume: 75 Issue: 6 Pages: 594-607

    • DOI

      10.1002/dneu.22268

    • Description
      【掲載確定】 印刷中
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decoding and deorphanizing an olfactory map2015

    • Author(s)
      H. Nishizumi and H. Sakano
    • Journal Title

      Nature Neuroscience

      Volume: 18 Issue: 10 Pages: 1432-1433

    • DOI

      10.1038/nn.4121

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmental regulation of neural map formation in the mouse olfactory system.2015

    • Author(s)
      Nishizumi H and Sakano H.
    • Journal Title

      Developmental Neurobiology

      Volume: 75 Pages: n/a-n/a

    • DOI

      10.1002/dneu

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A major allogenic leukocyte antigen in the agnathan hagfish.2013

    • Author(s)
      Hiroyuki Takaba
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 1716-1716

    • DOI

      10.1038/srep01716

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Circuit Formation of Mitral/Tufted Cells in the Mouse Olfactory System2015

    • Author(s)
      H. Nishizumi and H. Sakano
    • Organizer
      The 13th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A proximity model for synapse formation of mitral cells in the olfactory bulb.2014

    • Author(s)
      Nishizumi, H. and Sakano, H.
    • Organizer
      European Chemoreception Research Organization 24th Congress
    • Place of Presentation
      Dijon (France)
    • Year and Date
      2014-09-10 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Remarks] 高等生物繁栄の鍵「獲得免疫システム」の起源

    • URL

      http://www.s.u-tokyo.ac.jp/ja/story/newsletter/45/3.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi