The study to clarify the molecular mechanism of fate decision of activated CD4 T cells
Project/Area Number |
25670232
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | Ehime University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
OHARA Osamu 公益財団法人かずさDNA研究所, 副所長 (20370926)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 免疫 / T細胞 / 分化 / 老化 / 記憶 / 免疫学 / Bach2 / アレルギー / T細胞免疫記憶 |
Outline of Final Research Achievements |
In this study, we found that Menin plays a critical role in the fate decision of activated T cells. Menin was required for the memory CD4 and CD8 T cell generation. Furthermore, TCR/IL-2-mediated activation of Menin-deficient T cells in vitro resulted in the premature cellular senescence. Menin-deficient naive CD4 T cells preferentially differentiated into Th1 and Th2 cells in vitro, whereas Th17 cell differentiation was impaired. The phenotypes observed in the Menin-deficient T cells were partially mediated by the reduced expression of Bach2. Therefore, the Menin-Bach2 pathway plays an important role in the regulation T cell-mediated immune responses.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] The Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis2014
Author(s)
Kuwahara, M., Suzuki, J., Tofukuji, S., Yamada, T., Kanoh, M., Matsumoto, A., Maruyama, S., Kometani, K., Kurosaki, T., Ohara, O., Nakayama, T., Yamashita, M
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Journal Title
Nature Comm
Volume: 5
Issue: 1
Pages: 3555-3555
DOI
Related Report
Peer Reviewed / Open Access
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