• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Harmine regulates immune responses

Research Project

Project/Area Number 25670233
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionResearch Institute, International Medical Center of Japan (2014)
Keio University (2013)

Principal Investigator

KIMURA Akihiro  独立行政法人国立国際医療研究センター, その他部局等, その他 (20533318)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsハルミン / LPS / Th17 / Treg / アルカロイド / Th17細胞 / Treg細胞 / IL-6 / マクロファージ
Outline of Final Research Achievements

Harmine suppresses LPS-induced IL-6 production. Target X for harmine is required for the inhibition by harmine on IL-6 production. Furthermore, we found that harmine suppresses LPS-induced endotoxin shock.
While Harmine enhances the development of Treg cells, it inhibits Th17 cell differentiation. We demonstrated that Target X for harmine is required for enhancement of Treg cells and suppression of Th17 cells. These results indicate that harmine regulates the immune responses via the Target X for harmine.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells.2015

    • Author(s)
      Morita R, Suzuki M, Kasahara H, Shimizu N, Shichita T, Sekiya T, Kimura A, Sasaki K, Yasukawa H, Yoshimura A.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 112 Issue: 1 Pages: 160-165

    • DOI

      10.1073/pnas.1413234112

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aryl hydrocarbon receptor protects against bacterial infection by promoting macrophage survival and reactive oxygen species production2014

    • Author(s)
      Kimura A, Abe H, Tsuruta S, Chiba S, Fujii-Kuriyama Y, Sekiya T, Morita R, Yoshimura A.
    • Journal Title

      Int Immunol.

      Volume: 26 Issue: 4 Pages: 209-220

    • DOI

      10.1093/intimm/dxt067

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aryl hydrocarbon receptor plays protective roles in ConA-induced hepatic injury by both suppressing IFN-Y expression and inducing IL-222014

    • Author(s)
      Abe H, Kimura A, Tsuruta S, Fukaya T, Sakaguchi R, et al.
    • Journal Title

      Int Immunol.

      Volume: 26 Issue: 3 Pages: 129-137

    • DOI

      10.1093/intimm/dxt049

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.2013

    • Author(s)
      Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, et al.
    • Journal Title

      Nat Immunol.

      Volume: 14 Issue: 3 Pages: 230-237

    • DOI

      10.1038/ni.2520

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] IL-23-Independent Induction of IL-17 from γδT Cells and Innate Lymphoid Cells Promotes Experimental Intraocular Neovascularization2013

    • Author(s)
      Hasegawa E
    • Journal Title

      J Immunol

      Volume: 190 Issue: 4 Pages: 1778-1787

    • DOI

      10.4049/jimmunol.1202495

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Forced expression of stabilized c-Fos in dendritic cells reduces cytokine production and immune responses in vivo.2012

    • Author(s)
      Yoshida R
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 423 Issue: 2 Pages: 247-252

    • DOI

      10.1016/j.bbrc.2012.05.097

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Aryl hydrocarbon receptor controls autoimmunity through regulating the development of regulatory B cells.2013

    • Author(s)
      木村彰宏
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ、千葉
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] IL-10産生誘発AhRリガンドのスクリーニング方法2013

    • Inventor(s)
      木村彰宏、吉村昭彦
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-233833
    • Filing Date
      2013-11-12
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi