Harmine regulates immune responses
| Project/Area Number |
25670233
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Research Institute, International Medical Center of Japan (2014)
Keio University (2013) |
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Principal Investigator |
KIMURA Akihiro 独立行政法人国立国際医療研究センター, その他部局等, その他 (20533318)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ハルミン / LPS / Th17 / Treg / アルカロイド / Th17細胞 / Treg細胞 / IL-6 / マクロファージ |
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| Outline of Final Research Achievements |
Harmine suppresses LPS-induced IL-6 production. Target X for harmine is required for the inhibition by harmine on IL-6 production. Furthermore, we found that harmine suppresses LPS-induced endotoxin shock.
While Harmine enhances the development of Treg cells, it inhibits Th17 cell differentiation. We demonstrated that Target X for harmine is required for enhancement of Treg cells and suppression of Th17 cells. These results indicate that harmine regulates the immune responses via the Target X for harmine.
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Report
(3 results)
Research Products
(8 results)
