| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
In this study, we tried to expand our findings of ATP-medicated nucleotide excision inhibition, to biochemical, pharmacological, and structural aspects of DNA polymerases, via HIV reverse transcriptase as a model enzyme. We have established a novel assay system and screened over 5000 chemical compounds developed in the Tohoku University. Employing the identified several hits, structure-activity relation analysis is now in progress. In addition, we demonstrated that inhibitors for HIV reverse transcriptase appear to be experimentally suitable candidate to control differention process of mouse oocyte. Here we demonstrate that antiviral agents are useful for wide-range chemical biology tools as well as medical purpose.
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