Research for new therapeutic targets in multiple sclerosis
| Project/Area Number |
25670256
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Chiba University |
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Principal Investigator |
KASUYA Yoshitoshi 千葉大学, 医学(系)研究科(研究院), 准教授 (70221877)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 多発性硬化症 / 実験的自己免疫性脳脊髄炎 / p38 / エンドセリン / リン酸化酵素 / EAE / 発症メカニズム / 細胞内リン酸化酵素 / p38MAPK |
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| Outline of Final Research Achievements |
To research new therapeutic targets in multiple sclerosis, experimental autoimmune encephalomyelitis was conducted, and the following results were obtained. (1) Using p38α+/- mice resistant to the pathogenesis of EAE, plausible candidates involved in the development of EAE were evaluated. A DNA array analysis with the spinal cord samples showed that a significant difference in mRNA expression of sphingosine kinase 1, urokinase receptor, Ask2, Hexokinase 3 and STK32A was observed between WT and p38α+/- mice. (2) A bioactive substance, endothelin (ET) can regulate IL-17 production in Th17 cells through ETA receptor.
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] p38 mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease.2014
Author(s)
Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Kobayashi T, Ishida J, Fukamizu A, Sugiyama F, Sudo T, Kimura S, Tatsumi K, Kasuya Y.
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Journal Title
J Recept Signal Transduc
Volume: in press
Issue: 4
Pages: 299-306
DOI
Related Report
Peer Reviewed
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[Presentation] A role of p38 mitogen-activated protein kinase in emphysema induced by cigarette smoke solution and lipopolysaccharide in Mice.2014
Author(s)
Amano H, Murata K, Matsunaga H, Tanaka K, Kobayashi T, Ishida J, Fukamizu A, Sugiyama F, Kimura S, Tatsumi K, Kasuya Y.
Organizer
American Thoracic Society (ATS) 2014 International Conference
Place of Presentation
San Diego, USA
Year and Date
2014-05-16 – 2014-05-21
Related Report
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[Presentation] A simple and low-invasive sepsis mouse model.2014
Author(s)
Naito Y, Yoshioka Y, Tanaka K, Matsunaga H, Ishida J, Fukamizu A, Kimura S, Tatsumi K, Kasuya Y.
Organizer
American Thoracic Society (ATS) 2014 International Conference
Place of Presentation
San Diego, USA
Year and Date
2014-05-16 – 2014-05-21
Related Report
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