Investigation of the structuring of vasculogenic mimicry in rheumatoid arthritis synovium for novel therapy.

• Project/Area Number: 25670262
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Teikyo University
• Principal Investigator: Hirata Keiichi 帝京大学, 薬学部, 助手 (80424852)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 擬似血管 / 関節リウマチ / 滑膜

Outline of Final Research Achievements

The structuring of　vasculogenic mimicry (VM) is unknown in rheumatoid arthritis synovium. I propose the hypothesis that VM participates in disease malignancy of rheumatoid arthritis as well as cancer malignancy. And then, I focus on VM in rheumatoid arthritis synovium as the novel therapeutic target for rheumatoid arthritis. I investigated whether VM was assembled in rheumatoid arthritis synovium. The results suggested that VM was assembled in rheumatoid arthritis synovium of both human and mouse.