| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Based on the prototype peptide design, truncated form of the peptide which is enabled to restore the p14 tumor suppressor gene function was successfully obtained. The peptide could work inside the target tumor cells as a single functional form of p14-restoring sequence, by inserting the short motif which is cleaved in response to the tumor-specifically activated enzyme. The redesigned truncated p14 antitumor peptide efficiently exerted antitumor function in vitro and in vivo, which suggested to be practically available to suppress the growth of biologically aggressive tumors of the diverse origin.
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