Development of the novel peptide restoring the tumor suppressor function for peptide-based antitumor therapeutics
Project/Area Number |
25670263
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Applied pharmacology
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Research Institution | Niigata University (2014) 愛知県がんセンター(研究所) (2013) |
Principal Investigator |
KONDO Eisaku 新潟大学, 医歯学系, 教授 (30252951)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ペプチド / 分子治療 / がん / 癌抑制遺伝子 / p14ARF / 増殖抑制 |
Outline of Final Research Achievements |
Based on the prototype peptide design, truncated form of the peptide which is enabled to restore the p14 tumor suppressor gene function was successfully obtained. The peptide could work inside the target tumor cells as a single functional form of p14-restoring sequence, by inserting the short motif which is cleaved in response to the tumor-specifically activated enzyme. The redesigned truncated p14 antitumor peptide efficiently exerted antitumor function in vitro and in vivo, which suggested to be practically available to suppress the growth of biologically aggressive tumors of the diverse origin.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] NF-κB factors control the induction of NFATc1 in B lymphocytes.2014
Author(s)
Muhammad K, Alrefai H, Marienfeld R, Pham DA, Murti K, Patra AK, Avots A, Bukur V, Sahin U,Kondo E, Klein-Hessling S, Serfling E.
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Journal Title
Eur J Immunol.
Volume: 44(11)
Issue: 11
Pages: 3392-402
DOI
Related Report
Peer Reviewed
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[Journal Article] Antitumor Impact of p14ARF on Gefitinib-Resistant Non-Small Cell Lung Cancers.2013
Author(s)
Saito K, Takigawa N, Ohtani N, Iioka H, Tomita Y, Ueda R, Fukuoka J, Kuwahara K, Ichihara E, Kiura K, Kondo E.
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Journal Title
Molecule Cancer Therapeutics
Volume: 12
Issue: 8
Pages: 1616-1628
DOI
Related Report
Peer Reviewed
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