| Project/Area Number |
25670278
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
NAKAMURA Shinji 順天堂大学, 医学(系)研究科(研究院), 助教 (40207882)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUO Junji 北海道大学, 保健科学研究院, 講師 (50359486)
ISHIZU Akihiro 北海道大学, 保健科学研究院, 教授 (60321957)
|
|---|
| Research Collaborator |
YAMAGUCHI Hiroyuki 北海道大学, 保健科学研究院, 教授 (40221650)
ITO Shin
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | クラミジア / 性感染症 / インターロイキン１ / インターロイキン１レセプターアンタゴニスト / プロスタグランジンE2 / インターロイキン-1 / インターロイキン受容体アンタゴニスト / 診断マーカー / Chlamydia trachomatis / IL-1 / IL-1レセプターアンタゴニスト / 炎症性メディエーター / 感染症 |
|---|
| Outline of Final Research Achievements |
Chlamydia trachomatis is the most common sexually transmitted pathogen that the approximately 10% of infection are occurred. Leaving the chlamydia infection untreated, leading to complication such as tubal obstruction and fibrosis in part infected person is known, but the reason is unclear. In this study, we investigated the expression of inflammatory mediators including IL-1, IL-Ra, IL-6 and PGE2 to find a cause of complications, especially fibrosis by chlamydial infections. The positive cells of IL-1, IL-1Ra, and PGE2 were appeared in interstitial infiltrating cells, but there were no signification differences between infected patients with chlamydial and not infected patients. However, in chlamydia infected patient, squamous epithelium and columnar epithelium epithelium of the cervix. and glandular epithelia was celled IL-1 alpha and strong expressions of PGE2. The results suggest that PGE2 plays an important role in the precipitating factor of complication by chlamydia infection.
|
