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Healing and preventive approach with cellular senescence related gene, TARSH

Research Project

Project/Area Number 25670283
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionNational Center for Geriatrics and Gerontology

Principal Investigator

MARUYAMA Mitsuo  独立行政法人国立長寿医療研究センター, 老化機構研究部, 部長 (00212225)

Research Collaborator IWASHITA Yuji  独立行政法人国立長寿医療研究センター, 老化機構研究部, 流動研究員 (70730406)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺癌 / 細胞老化 / 遺伝子発現 / 転写 / TARSH / 転写制御 / 癌抑制 / バイオマーカー / 遺伝子発現制御
Outline of Final Research Achievements

Aging is known as an irreversible decline of various tissue functions. We have identified a gene, target of NESH-SH3 (TARSH/Abi3bp) that was robustly upregulated at the beginning of cellular senescence in mouse embryonic fibroblasts. In addition, TARSH gene was dominantly expressed in lung tissue but the expression was strongly suppressed in human lung cancer specimens. These results suggest TARSH gene expression is involved in regulation of cellular proliferation and tumorigenesis. We predicted the candidate promoter of TARSH gene that includes the upstream of transcriptional initiation site and first intron, and validated the promoter function of that region. We are now going to narrow the functional region of the TARSH promoter. Consequently elucidation of senescence-associated regulation of TARSH gene expression may contribute to understanding the potential common mechanism underlying senescence, physiological aging and geriatric diseases including cancer.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 Other

All Presentation (13 results) (of which Invited: 4 results)

  • [Presentation] Investigation of a cellular senescence-related gene, TARSH/Abi3bp in cellular proliferation and lung cancer metastasis2015

    • Author(s)
      岩下雄二、原田種展、石澤和也、松田剛典、寺内邦彦、島田順一、杉本昌隆、丸山光生
    • Organizer
      第7回NAGOYAグローバルリトリート
    • Place of Presentation
      愛知
    • Year and Date
      2015-02-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of functional promoter region of a cellular senescence-related gene, TARSH/Abi3bp2015

    • Author(s)
      石澤和也、岩下雄二、松田剛典、杉本昌隆、丸山光生
    • Organizer
      第7回NAGOYAグローバルリトリート
    • Place of Presentation
      愛知
    • Year and Date
      2015-02-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of functional promoter region of a cellular senescence-related gene, TARSH2014

    • Author(s)
      Ishizawa K, Iwashita Y, Matsuda T, Sugimoto M, Maruyama M
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Implication of a cellular senescence-related gene, TARSH/Abi3bp in cellular proliferation and lung cancer metastasis2014

    • Author(s)
      Iwashita Y, Harada T, Ishizawa K, Matsuda T, Terauchi K, Shimada J, Sugimoto M, Maruyama M
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Physiological implication of cellular senescence–related gene, TARSH/Abi3bp in cancer proliferation and metastasis.2014

    • Author(s)
      Maruyama M
    • Organizer
      2014 Mini-symposium on “Aging and Oxidative stress”
    • Place of Presentation
      Chunchoen, Gangwon-do Korea
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Functional role of a cellular senescence-related gene, TARSH/Abi3bp in cell proliferation and cancer metastasis2014

    • Author(s)
      Iwashita Y, Harada T, Matsuda T, Terauchi K, Shimada J, Sugimoto M, Maruyama M.
    • Organizer
      Molecular Genetics of Aging, Cold Spring Harbor Laboratory Meeting
    • Place of Presentation
      Cold Spring Harbor, NY, USA
    • Year and Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Implication of a cellular senescence-related gene, TARSH in cell proliferation and cancer metastasis2014

    • Author(s)
      Iwashita Y, Harada T, Matsuda T, Sugimoto M, Maruyama M.
    • Organizer
      The 37th Annual Meeting of Japan Society for Biomedical Gerontology
    • Place of Presentation
      Aichi
    • Year and Date
      2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Putative function of a cellular senescence-related gene, TARSH/Abi3bp in cell proliferation and cancer metastasis2014

    • Author(s)
      Iwashita Y, Harada T, Matsuda T, Sugimoto M, Maruyama M.
    • Organizer
      2014 Korea-Japan Joint Symposium and Annual Meeting of Korean Society for Gerontology
    • Place of Presentation
      Jeju Island, South Korea
    • Year and Date
      2014-06-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 老化関連因子TARSHの細胞老化と癌抑制に関する機能解析

    • Author(s)
      原田種展、松田剛典、杉本昌隆、寺内邦彦、島田順一、丸山光生
    • Organizer
      第36回日本基礎老化学会
    • Place of Presentation
      大阪市
    • Related Report
      2013 Research-status Report
  • [Presentation] 細胞老化関連分子TARSHの肺癌における機能解析

    • Author(s)
      原田種展、松田剛典、下村雅律、寺内邦彦、島田順一、杉本昌隆、丸山光生
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Research-status Report
  • [Presentation] Putative role of cellular senescence related gene, TARSH/Abi3bp in lung cancer.

    • Author(s)
      Maruyama Mitsuo
    • Organizer
      Asian Association of Aging Research(AAAR2013)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 細胞老化関連遺伝子TARSH/ABi3bpの肺癌における機能解析

    • Author(s)
      丸山光生
    • Organizer
      長崎大学大学院医歯薬総合研究科大学院セミナー
    • Place of Presentation
      長崎市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Implication of a cellular senescence-related gene, TARSH in cell proliferation and cancer metastasis

    • Author(s)
      IWASHITA Yuji, HARADA Tanenobu, MATSUDA Takenori, SUGIMOTO Masataka, MARUYAMA Mitsuo
    • Organizer
      第37回日本基礎老化学会大会
    • Place of Presentation
      知多郡東浦町
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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