| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Although CRPS accompanied a severe uncontrollable pain on a given tissue with a syndrome on autonomic nervous system. This highlight the characteristics of CRPS as not only pain syndrome but also suggesting an involvement of systematic control mechanism in the affected individual. The identification of metallothionein deficiency in the affected peripheral nerves has opened up a new paradigm in this field. This is the first example that an evidence for molecular changes and identification of particular protein molecule in the CRPS nerve tissues. In this proposal, we took advantage of proteomics to detect more proteins changes in the peripheral nerve tissues of CRPS in comparison with intact sensory nerves obtained from fresh cadaver. Using antibody array for proteomic analysis, we found a novel involvement of NGF system in CRPS. Using these new information, we are now trying to establish objective diagnosis system for neuropathic pain including CRPS.
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