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To assess the risk of Attention Deficit/ Hyper Activity Disorder cause by Epigenetic action and gene environment interaction.

Research Project

Project/Area Number 25670291
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Epidemiology and preventive medicine
Research InstitutionHokkaido University

Principal Investigator

KISHI Reiko  北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449)

Co-Investigator(Kenkyū-buntansha) MUROHASHI Harumitsu  北海道大学, 大学院教育学研究院, 教授 (00182147)
SHIRAISHI Hideaki  北海道大学, 北海道大学病院, 助教 (80374411)
IKENO Tamiko  北海道大学, 環境健康科学研究教育センター, 特任講師 (80569715)
MIYASHITA Chihiro  北海道大学, 環境健康科学研究教育センター, 特任講師 (70632389)
Co-Investigator(Renkei-kenkyūsha) TOMOYUKI Hanaoka  北海道大学, 環境健康科学研究教育センター, 教授 (00228503)
SEIKO Sasaki  北海道大学, 大学院医学研究院, 助教 (30448831)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords環境疫学 / ADHD / 喫煙曝露 / 環境遺伝交互作用 / 葉酸
Outline of Final Research Achievements

Concerning 8 year old children who participated in Hokkaido study on Environmental and Children’s health, we investigated with the Conner3P Japanese version (attention deficit hyperactivity disorder), ADHD-RS and clarified the risk of environmental factors. For example, smoking during pregnancy, taking the folic acid supplements etc. The result of the 2,545 collected questionnaires was that smoking during pregnancy increased the prevalence of the ADHD trend (OR=2.2;95%CI,1.002-4.631).
Furthermore, the ADHD -suspected group (N=138) and control group in nested case control study, the SNPs of neurotransmitter related gene (DRD4,DAT1,HTR1B,COMT,SNAP25)and brain-derived neurotrophic factor (BDNF)were investigated by EP1 system (Fludigm.com). Analyzing 200 cases have completed and 190 cases are ongoing analyzing SNPs.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (35 results)

All 2015 2014 2013 Other

All Journal Article (11 results) (of which Peer Reviewed: 8 results,  Open Access: 6 results) Presentation (17 results) Book (3 results) Remarks (4 results)

  • [Journal Article] Demographic, behavioral, dietary and socioeconomic characteristics related to persistent organic pollutants and mercury levels in pregnant woman in Japan2015

    • Author(s)
      Miyashita C., Sasaki S., Saijo Y., Okada E., Kobayashi S., Baba T., Kajiwara J., Todaka T., Iwasaki Y., Nakazawa H., Hachiya N., Yasutake A., Murata K., Kishi R.
    • Journal Title

      Chemosphere

      Volume: 133 Pages: 13-21

    • DOI

      10.1016/j.chemosphere.2015.02.062

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attention that covers letters is necessary ofr the left-lateralization of an erarly print-tuned ERP in Japanese hiragana.2015

    • Author(s)
      Okumura,Y., Kasai,T., and Murohashi,H.
    • Journal Title

      Neuropychologia

      Volume: 69 Pages: 22-30

    • DOI

      10.1016/j.neuropsychologia.2015.01.026

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【公害・環境問題の変貌と新展開】環境化学物質の次世代影響 出生コホート研究による成果と今後の課題2014

    • Author(s)
      岸 玲子
    • Journal Title

      公衆衛生

      Volume: 78(8) Pages: 547-552

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] Early print-tuned ERP response with minimal involvement of linguistic processing in Japanese Hiragana strings2014

    • Author(s)
      Okumura Y., Kasai T., & Murohashi H.
    • Journal Title

      Neuroreport

      Volume: 25 Issue: 6 Pages: 410-414

    • DOI

      10.1097/wnr.0000000000000110

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 発達障害におけるワーキングメモリー特性を生かした学習支援2014

    • Author(s)
      室橋 春光
    • Journal Title

      LD研究―研究と実践

      Volume: 23(2) Pages: 134-141

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] 発達とは何かー特別支援教育の視点から2014

    • Author(s)
      室橋 春光
    • Journal Title

      子ども発達臨床研究

      Volume: 6 Pages: 49-53

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] Association between maternal antenatal depression and infant development: a hospital-based prospective cohort study2014

    • Author(s)
      Otake Y, Nakajima S, Uno A, Kato S, Sasaki S, Yoshioka E, Ikeno T, Kishi R
    • Journal Title

      Environment Health Preventive Medicine

      Volume: 19(1) Issue: 1 Pages: 30-45

    • DOI

      10.1007/s12199-013-0353-7

    • NAID

      210000000292

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetoencephalography localizing spike sources of atypical benign partial epilepsy2014

    • Author(s)
      Shiraishi H, Haginoya K, Nakagawa E,Saitoh S, Kaneko Y, Nakasato N, Chan D, Otsubo H
    • Journal Title

      Brain Dev

      Volume: 36 Issue: 1 Pages: 21-27

    • DOI

      10.1016/j.braindev.2012.12.011

    • NAID

      120005397862

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies2013

    • Author(s)
      Yamada T, Morikawa M, Yamada T, Kishi R, Sengoku K, Endo T, Saito T, Cho K, Minakami H.
    • Journal Title

      Archives of gynecology and obstetrics

      Volume: 287 Issue: 1 Pages: 9-14

    • DOI

      10.1007/s00404-012-2501-5

    • NAID

      120005358926

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ten years of progress in the Hokkaido birth cohort study on environment and children's health : cohort profile--updated 2013.2013

    • Author(s)
      Kishi R, Kobayashi S, Ikeno T, Araki A, Miyashita C, Itoh S, Sasaki S, Okada E, Kobayashi S, Kashino I, Itoh K, Nakajima S ; Members of the Hokkaido Study on Environment and Children's Health.
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 18 Issue: 6 Pages: 429-450

    • DOI

      10.1007/s12199-013-0357-3

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] MEGによるfunctional connectivityの解析 ‐Default Mode Networkモデルに関連した Autism Spectrum Disorderと定型発達の比較‐2013

    • Author(s)
      豊巻敦人, 渡辺隼人, 柳生一自, 室橋春光
    • Journal Title

      生理心理学と精神生理学

      Volume: 31(1) Pages: 41-49

    • NAID

      130004876235

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 臍帯血ビスフェノールA濃度と児のIGF2 DNAメチル化との関連—北海道スタディ2015

    • Author(s)
      小林祥子,安住薫,佐々木成子,松村徹,山本潤,石塚真由美,宮下ちひろ,池野多美子,荒木敦子,岸玲子
    • Organizer
      第85回日本衛生学会学術総会.
    • Place of Presentation
      和歌山県文化会館(和歌山県・和歌山市)
    • Year and Date
      2015-03-23 – 2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ダイオキシン類曝露と胎児発育との関連: 遺伝的なリスクについて―北海道スタディ―2015

    • Author(s)
      小林澄貴,宮下ちひろ,佐々木成子,荒木敦子,佐田文宏,坂晋,梶原淳睦,戸高尊,岸玲子
    • Organizer
      第85回日本衛生学会学術総会.
    • Place of Presentation
      和歌山県文化会館(和歌山県・和歌山市)
    • Year and Date
      2015-03-23 – 2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Not all but the most patients with CSWS are Atypical Benign Partial Epilepsy in Childhood.2014

    • Author(s)
      Hideaki Shiraishi, Kiyoshi Egawa, Kosuke Otsuka, Midori Nakajima, Tomoshiro Ito, Masashi Narugami, Shingo Nakane, Kayoko Takahashi
    • Organizer
      2014 AES 68th Annual Meeting
    • Place of Presentation
      Washington State Convention Center(Seattle, USA)
    • Year and Date
      2014-12-05 – 2014-12-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胎児期の母の受動喫煙が児の出生時体格に及ぼす影響: 遺伝環境交互作用について2014

    • Author(s)
      小林澄貴, 佐々木成子, 佐田文宏, 宮下ちひろ, 池野多美子, 荒木敦子, 岸玲子
    • Organizer
      第66回北海道公衆衛生学会.
    • Place of Presentation
      北海道大学 学術交流会館(北海道・札幌市)
    • Year and Date
      2014-12-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hokkaido Study on Environment and Children’s Health: Cohort profile and findings of perinatal Perfluoroalkyl acid (PFAAs)exposure and various health outcomes.2014

    • Author(s)
      Reiko Kishi, Atsuko Araki
    • Organizer
      2014 Conference of International Society for Environmental Epidemiology Asia Chapter
    • Place of Presentation
      Xinhua Hospital, Shanghai, China
    • Year and Date
      2014-11-30 – 2014-12-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 認知的機能のアンバランスな子どもの教育2014

    • Author(s)
      室橋 春光
    • Organizer
      日本LD学会第23回大会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2014-11-23 – 2014-11-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 北海道における妊婦の職域における化学物質曝露・受動喫煙および飲酒習慣が児の出生時体格に及ぼす影響.2014

    • Author(s)
      小林澄貴, 荒木敦子, 宮下ちひろ, 池野多美子, 伊藤佐智子, 伊藤久美子, Goudarzi Houman, 田村菜穂美, 岸玲子
    • Organizer
      平成26年度日本産業衛生学会北海道地方会.
    • Place of Presentation
      札幌市医師会館(北海道・札幌市)
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Twelve years of progress in the Hokkaido birth cohort study on environment and children's health: malformation, development and allergy.2014

    • Author(s)
      Kishi R.
    • Organizer
      International Symposium of Environmental Medicine Program
    • Place of Presentation
      National Taiwan University, Taipei Taiwan
    • Year and Date
      2014-10-16 – 2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Twelve Years of Progress in the Hokkaido Birth Cohort Study on Environment and Children's Health: Focused on Dioxins and PFCs.2014

    • Author(s)
      Kishi R
    • Organizer
      Summit on Child Health and the Environment 2014.
    • Place of Presentation
      Hong Kong Academy of medicine Building, Hong Kong, China
    • Year and Date
      2014-10-11 – 2014-10-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] てんかんと睡眠:睡眠中にみられるてんかん発作~発達期2014

    • Author(s)
      白石秀明
    • Organizer
      第48回日本てんかん学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2014-10-02 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] The effects of perfluoroalkyl acids (PFAAs) exposure in utero on IGF2/H19 DNA methylation in cord blood.2014

    • Author(s)
      Kobayashi S., Azumi K., Sasaki S., Ishizuka M., Nakazawa H., Okada E., Kobayashi S., Goudarzi H., Itoh S., Miyashita C., Ikeno T., Araki A., Kishi R
    • Organizer
      26th Annual International Society for Environmental Epidemiology Conference - From Local to Global: Advancing Science for Policy in Environmental Health
    • Place of Presentation
      University of Washington, Seattle USA
    • Year and Date
      2014-08-24 – 2014-08-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 妊婦の受動喫煙が児の出生時体格へ及ぼす影響:遺伝的なハイリスク群について-環境と子どもの健康に関する北海道スタディ-.2014

    • Author(s)
      小林澄貴, 佐々木成子, 佐田文宏, 宮下ちひろ, 池野多美子, 荒木敦子, 岸玲子
    • Organizer
      北海道小児保健研究会
    • Place of Presentation
      札幌医科大学(北海道・札幌市)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 妊婦葉酸値と8歳時ADHD関連症状の関係:環境と子どもの健康に関する北海道スタディ2013

    • Author(s)
      池野多美子, 喜多歳子, 小林澄貴, 岸玲子
    • Organizer
      第65回北海道公衆衛生学会
    • Place of Presentation
      札幌市生涯学習センター ちえりあ(札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 8歳の注意欠損多動性障害に関する要因--環境と子どもの健康に関する北海道スタディ--2013

    • Author(s)
      池野多美子, 小林澄貴, 喜多歳子, 中島そのみ, 岸玲子
    • Organizer
      第72回日本公衆衛生学会総会
    • Place of Presentation
      三重県総合文化センター(津市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 親の世帯収入と48か月児の知的能力(K-ABC)との関連;環境と子どもの健康に関する前向きコホート研究(北海道スタディ)の結果2013

    • Author(s)
      喜多歳子, 池野多美子, 中島そのみ, 小林澄貴, 岸玲子
    • Organizer
      第72回日本公衆衛生学会総会
    • Place of Presentation
      三重県総合文化センター(津市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 脳磁場計測を用いた乳児・小児障害脳における言語機能獲得の予後評価2013

    • Author(s)
      白石秀明, 竹内文也, 大塚耕右, 柳生一自, 朝比奈直子, 香坂忍, 高橋香代子, 中根進児
    • Organizer
      第43回日本臨床神経生理学会
    • Place of Presentation
      ザ クラウンパレス新阪急高知・三翠園(高知市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Multi-measured assessment for developmental dyslexia2013

    • Author(s)
      Murohashi,H., Itagaki S., Yokoyama, S., Yagyu K.
    • Organizer
      International Association for the Scientific Study of Intellectual and Developmental Disabilities(IASSID) Asia-Pacific Congress
    • Place of Presentation
      Waseda Univ.(東京都)
    • Related Report
      2013 Research-status Report
  • [Book] 睡眠とてんかん:睡眠と小児てんかん2015

    • Author(s)
      白石秀明(著)千葉 茂(編集)
    • Publisher
      ライフサイエンス
    • Related Report
      2014 Annual Research Report
  • [Book] 別冊 日本臨床 神経症候群(第2版)VI2014

    • Author(s)
      白石秀明(著) 日本臨床(編集)
    • Publisher
      日本臨床社
    • Related Report
      2014 Annual Research Report
  • [Book] 睡眠中にみられるてんかん発作:発達期 「睡眠医療」Vol.7 No.22013

    • Author(s)
      白石秀明(著), 千葉茂(編)
    • Publisher
      ライフサイエンス
    • Related Report
      2013 Research-status Report
  • [Remarks] 環境健康科学研究教育センター 研究業績

    • URL

      http://www.cehs.hokudai.ac.jp/research/yearly/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 環境と健康ひろば

    • URL

      http://www.cehs.hokudai.ac.jp/hiroba/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 環境健康科学研究教育センター 研究業績

    • URL

      http://www.cehs.hokudai.ac.jp/research/yearly/

    • Related Report
      2013 Research-status Report
  • [Remarks] 環境と健康ひろば

    • URL

      http://www.cehs.hokudai.ac.jp/hiroba/

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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