To assess the risk of Attention Deficit/ Hyper Activity Disorder cause by Epigenetic action and gene environment interaction.
| Project/Area Number |
25670291
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
KISHI Reiko 北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449)
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| Co-Investigator(Kenkyū-buntansha) |
MUROHASHI Harumitsu 北海道大学, 大学院教育学研究院, 教授 (00182147)
SHIRAISHI Hideaki 北海道大学, 北海道大学病院, 助教 (80374411)
IKENO Tamiko 北海道大学, 環境健康科学研究教育センター, 特任講師 (80569715)
MIYASHITA Chihiro 北海道大学, 環境健康科学研究教育センター, 特任講師 (70632389)
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| Co-Investigator(Renkei-kenkyūsha) |
TOMOYUKI Hanaoka 北海道大学, 環境健康科学研究教育センター, 教授 (00228503)
SEIKO Sasaki 北海道大学, 大学院医学研究院, 助教 (30448831)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 環境疫学 / ADHD / 喫煙曝露 / 環境遺伝交互作用 / 葉酸 |
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| Outline of Final Research Achievements |
Concerning 8 year old children who participated in Hokkaido study on Environmental and Children’s health, we investigated with the Conner3P Japanese version (attention deficit hyperactivity disorder), ADHD-RS and clarified the risk of environmental factors. For example, smoking during pregnancy, taking the folic acid supplements etc. The result of the 2,545 collected questionnaires was that smoking during pregnancy increased the prevalence of the ADHD trend (OR=2.2;95%CI,1.002-4.631).
Furthermore, the ADHD -suspected group (N=138) and control group in nested case control study, the SNPs of neurotransmitter related gene （DRD4,DAT1,HTR1B,COMT,SNAP25）and brain-derived neurotrophic factor （BDNF）were investigated by EP1 system (Fludigm.com). Analyzing 200 cases have completed and 190 cases are ongoing analyzing SNPs.
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] Demographic, behavioral, dietary and socioeconomic characteristics related to persistent organic pollutants and mercury levels in pregnant woman in Japan2015
Author(s)
Miyashita C., Sasaki S., Saijo Y., Okada E., Kobayashi S., Baba T., Kajiwara J., Todaka T., Iwasaki Y., Nakazawa H., Hachiya N., Yasutake A., Murata K., Kishi R.
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Journal Title
Chemosphere
Volume: 133
Pages: 13-21
DOI
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Peer Reviewed / Open Access
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[Journal Article] Ten years of progress in the Hokkaido birth cohort study on environment and children's health : cohort profile--updated 2013.2013
Author(s)
Kishi R, Kobayashi S, Ikeno T, Araki A, Miyashita C, Itoh S, Sasaki S, Okada E, Kobayashi S, Kashino I, Itoh K, Nakajima S ; Members of the Hokkaido Study on Environment and Children's Health.
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Journal Title
Environmental Health and Preventive Medicine
Volume: 18
Issue: 6
Pages: 429-450
DOI
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Peer Reviewed
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[Presentation] The effects of perfluoroalkyl acids (PFAAs) exposure in utero on IGF2/H19 DNA methylation in cord blood.2014
Author(s)
Kobayashi S., Azumi K., Sasaki S., Ishizuka M., Nakazawa H., Okada E., Kobayashi S., Goudarzi H., Itoh S., Miyashita C., Ikeno T., Araki A., Kishi R
Organizer
26th Annual International Society for Environmental Epidemiology Conference - From Local to Global: Advancing Science for Policy in Environmental Health
Place of Presentation
University of Washington, Seattle USA
Year and Date
2014-08-24 – 2014-08-28
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