Association of vitamin K deficiency and musculoskeletal disorders: a population-based cohort study

• Project/Area Number: 25670293
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Rehabilitation Center for Persons with Disabilities (2014-2015); The University of Tokyo (2013)
• Principal Investigator: AKUNE Toru 国立障害者リハビリテーションセンター(研究所), 病院(併任研究所), 副院長 (60282662)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Noriko 東京大学, 医学部附属病院, 特任准教授 (60240355) ; MURAKI Shigeyuki 東京大学, 医学部附属病院, 特任准教授 (40401070) ; OKA Hiroyuki 東京大学, 医学部附属病院, 特任助教 (60401064)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 医療・福祉 / 疫学 / コホート研究 / 栄養 / 運動器障害 / 要介護

Outline of Final Research Achievements

We performed epidemiologic surveys in 2453 participants of Japanese population-based cohorts. Dietary vitamin K intake was assessed by a questionnaire and the percentage of dietary vitamin K intake less than 150 microgram/d was 15%. Association of dietary vitamin K intake with minimum joint space width and osteophyte area on the plain X-ray film of the knee was examined in 827 participants. A multivariate logistic regression analysis revealed that low dietary intake of vitamins K was significantly associated with minimum joint space width and osteophyte area on the knee, indices of knee osteoarthritis.

Research Products

• [Journal Article] Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study. (2016)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Oka H, Minamide A, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: e0147565-e0147565
  • DOI: 10.1371/journal.pone.0147565
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Prevalence of radiographic hip osteoarthritis and its association with hip pain in Japanese men and women: The ROAD study. (2016)
  • Author(s): Iidaka T, Muraki S, Akune T, Oka H, Kodama R, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 24 Issue: 1 Pages: 117-123
  • DOI: 10.1016/j.joca.2015.07.017
  • Peer Reviewed
• [Journal Article] The association of combination of disc degeneration, endplate signal change, and Schmorl node with low back pain in a large population study: the Wakayama Spine Study (2015)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Oka H, Minamide A, Nakagawa H, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Journal Title: Spine J Volume: 15 Issue: 4 Pages: 622-628
  • DOI: 10.1016/j.spinee.2014.11.012
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Quadriceps muscle strength, radiographic knee osteoarthritis and knee pain: The ROAD study. (2015)
  • Author(s): Muraki S, Akune T, Teraguchi M, Kagotani R, Asai Y, Yoshida M, Tokimura F, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: BMC musculoskeltal disorders Volume: 16 Issue: 1 Pages: 305-305
  • DOI: 10.1186/s12891-015-0737-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Joint space narrowing, body mass index and knee pain: The ROAD study. (2015)
  • Author(s): Muraki S, Akune T, En-yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Tanaka S, Nakamura K, Kawaguchi H, Oka H, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 23 Issue: 6 Pages: 874-881
  • DOI: 10.1016/j.joca.2015.01.011
  • Peer Reviewed
• [Journal Article] Does osteophytosis at the knee predict health-related quality of life decline? A 3-year follow-up of the ROAD study. (2015)
  • Author(s): Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N.
  • Journal Title: Clin Rheumatol. Volume: 34 Issue: 9 Pages: 1589-1597
  • DOI: 10.1007/s10067-014-2687-y
  • Peer Reviewed
• [Journal Article] Association between new indices in the locomotive syndrome risk test and decline in mobility: third survey of the ROAD study. (2015)
  • Author(s): Yoshimura N, Musaki S, Oka H, Tanaka S, Ogata T, Kawaguchi H, Akune T, Nakamura K
  • Journal Title: J Orthop Sci Volume: 20 Issue: 5 Pages: 896-905
  • DOI: 10.1007/s00776-015-0741-5
  • Peer Reviewed / Open Access
• [Journal Article] Factors affecting changes in the serum levels of 25-hydroxyvitamin D: A 3-year follow-up of the ROAD study. (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Nakamura K, Kawaguchi H, Tanaka S, Akune T
  • Journal Title: Osteoporos Int Volume: 26 Issue: 11 Pages: 2597-605
  • DOI: 10.1007/s00198-015-3184-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Urinary 8-iso-prostaglandin F2a as a marker of metabolic risks in the general Japanese population: The ROAD study. (2015)
  • Author(s): Mure K, Yoshimura N, Hashimoto M, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Takeshita T
  • Journal Title: Obesity 23:1517-1524, 2015. Volume: 23 Issue: 7 Pages: 1517-1524
  • DOI: 10.1002/oby.21130
  • Peer Reviewed
• [Journal Article] Mutual associations among musculoskeletal diseases and metabolic syndrome components: A 3-year follow-up of the ROAD study. (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T.
  • Journal Title: Mod Rheumatol. Volume: 25 Issue: 3 Pages: 438-448
  • DOI: 10.3109/14397595.2014.972607
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Serum levels of 25-hydroxyvitamin D and occurrence of musculoskeletal diseases, such as osteoporosis, knee osteoarthritis and lumbar spondylosis: A three-year follow-up of the road study. (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Nakamura K, Kawaguchi H, Tanaka S, Akune T
  • Journal Title: Osteoporos Int Volume: 26 Issue: 1 Pages: 151-161
  • DOI: 10.1007/s00198-014-2844-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Incidence of disability and its associated factors in Japanese men and women: the Longitudinal Cohorts of Motor System Organ (LOCOMO) study. (2015)
  • Author(s): Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Nishiwaki Y, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K.
  • Journal Title: J Bone Miner Metab Volume: 33 Issue: 2 Pages: 186-191
  • DOI: 10.1007/s00774-014-0573-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) of the whole spine and its association with lumbar spondylosis and knee osteoarthritis: the ROAD study. (2015)
  • Author(s): Kagotani R, Yoshida M, Muraki S, Oka H, Hashizume H, Yamada H, Enyo Y, Nagata K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N.
  • Journal Title: J Bone Miner Metab Volume: 33 Issue: 2 Pages: 221-229
  • DOI: 10.1007/s00774-014-0583-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The prevalence of cervical myelopathy among subjects with narrow cervical spinal canal in a population-based MRI study: The Wakayama Spine Study. (2014)
  • Author(s): 52. Nagata K, Yoshimura N, Hashizume H, Muraki S, Ishimoto Y, Yamada H, Takiguchi N, Nakagawa Y, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Journal Title: Spine J Volume: in press Issue: 12 Pages: 2811-2817
  • DOI: 10.1016/j.spinee.2014.03.051
  • Peer Reviewed / Open Access
• [Journal Article] Association of knee osteoarthritis with onset and resolution of pain and physical functional disability: the ROAD study. (2014)
  • Author(s): Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Mod Rheumatol. Volume: 24 Issue: 6 Pages: 966-973
  • DOI: 10.3109/14397595.2014.883055
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Incidence of certified need of care in the long-term care insurance system and its risk factors in the elderly of Japanese population-based cohorts: The ROAD study. (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N
  • Journal Title: Geriatr Gerontol Int Volume: 14 Issue: 3 Pages: 695-701
  • DOI: 10.1007/s00776-014-0537-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prevalence, incidence and progression of lumbar spondylosis by gender and age strata. (2014)
  • Author(s): Muraki S, Yoshimura N, Akune T, Tanaka S, Takahashi I, Fujiwara S
  • Journal Title: Mod Rheumatol Volume: 24 Issue: 4 Pages: 657-661
  • DOI: 10.3109/14397595.2013.843761
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Incidence of certified need of care in the long-term care insurance system and its risk factors in the elderly of Japanese population-based cohorts: The ROAD study. (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N.
  • Journal Title: Geriatr Gerontol Int Volume: in press Issue: 3 Pages: 695-701
  • DOI: 10.1111/ggi.12155
  • Peer Reviewed / Open Access
• [Journal Article] Association of dietary intake with joint space narrowing and osteophytosis at the knee in Japanese men and women: the ROAD study. (2014)
  • Author(s): Muraki S, Akune T, En-Yo Y, Yoshida M, Tanaka S, Kawaguchi H, Nakamura K, Oka H, Yoshimura N
  • Journal Title: Mod Rheumatol Volume: 24 Issue: 2 Pages: 236-42
  • DOI: 10.3109/14397595.2013.854055
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study. (2014)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Minamide A, Oka H, Ishimoto Y, Nagata K, Kagotani R, Takiguchi N, Akune T, Kawaguchi H, Nakamura K, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: 22 Issue: 1 Pages: 104-110
  • DOI: 10.1016/j.joca.2013.10.019
  • Peer Reviewed
• [Journal Article] Exercise habits during middle age are associated with lower prevalence of sarcopenia: the ROAD study. (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Osteoporos Int Volume: 25 Issue: 3 Pages: 1081-8
  • DOI: 10.1007/s00198-013-2550-z
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence and progression of the radiographic ossification of posterior longitudinal ligament and its associated factors in the Japanese populations: A 3-year follow-up of the ROAD study. (2014)
  • Author(s): Yoshimura N, Nagata K, Muraki S, Oka H, Yoshida M, Enyo Y, Kagotani R, Hashizume H, Yamada H, Ishimoto Y, Teraguchi M, Tanaka S, Kawaguchi H, Toyama Y, Nakamura K, Akune T
  • Journal Title: Osteoporos Int Volume: 25 Issue: 3 Pages: 1089-1098
  • DOI: 10.1007/s00198-013-2489-0
  • Peer Reviewed
• [Journal Article] Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) of the whole spine and its association with lumbar spondylosis and knee osteoarthritis: the ROAD study. (2014)
  • Author(s): Kagotani R, Yoshida M, Muraki S, Oka H, Hashizume H, Yamada H, Enyo Y, Nagata K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N.
  • Journal Title: J Bone Miner Metab Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Association of knee osteoarthritis with onset and resolution of pain and physical functional disability: The ROAD study. (2014)
  • Author(s): Muraki S, Akune T, Nagata K, Ishimoto Y, Yoshida M, Tokimura F, Tanaka S, Oka H, Kawaguchi H, Nakamura K, Yoshimura N.
  • Journal Title: Mod Rheumatol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Association of physical activities of daily living with the incidence of certified need of care in the long-term care insurance system of Japan: the ROAD study. (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N.
  • Journal Title: J Orthop Sci Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Prevalence, incidence and progression of lumbar spondylosis by gender and age strata. (2014)
  • Author(s): Muraki S, Yoshimura N, Akune T, Tanaka S, Takahashi I, Fujiwara S.
  • Journal Title: Mod Rheumatol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Prevalence of knee pain, lumbar pain and its coexistence in Japanese men and women : The Longitudinal Cohorts of Motor System Organ (LOCOMO) study (2013)
  • Author(s): Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Omori G, Sudo A, Nishiwaki Y, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K
  • Journal Title: J Bone Miner Metab Volume: 32 Issue: 5 Pages: 524-532
  • DOI: 10.1007/s00774-013-0522-1
  • Peer Reviewed / Open Access
• [Journal Article] Profiles of vitamin D insufficiency and deficiency in Japanese men and women: association with biological, environmental, and nutritional factors and coexisting disorders: the ROAD study. (2013)
  • Author(s): Yoshimura N, Muraki S, Oka H, Morita M, Yamada H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: Osteoporos Int Volume: 24 Issue: 11 Pages: 2775-2787
  • DOI: 10.1007/s00198-013-2372-z
  • Peer Reviewed / Open Access
• [Journal Article] Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: The Wakayama Spine Study. (2013)
  • Author(s): Ishimoto Y
  • Journal Title: Osteoarthritis and Cartilage Volume: 印刷中 Issue: 6 Pages: 783-788
  • DOI: 10.1016/j.joca.2013.02.656
  • Peer Reviewed
• [Journal Article] The mid-term efficacy of intra-articular hyaluronic acid injections on joint structure: A nested case-control study. (2013)
  • Author(s): Oka H, Akune T, Muraki S, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N.
  • Journal Title: Modern Rheum Volume: 23 Issue: 4 Pages: 722-8
  • DOI: 10.1007/s10165-012-0725-7
  • NAID: 10031189167
  • Peer Reviewed
• [Presentation] 25水酸化ビタミンDと骨粗鬆症：ROAD studyから (2015)
  • Author(s): 吉村典子、村木重之、岡敬之、田中栄、川口浩、中村耕三、阿久根徹
  • Organizer: 第17回日本骨粗鬆症学会
  • Place of Presentation: 広島国際会議場（広島市）
  • Year and Date: 2015-09-17
• [Presentation] サルコペニアと骨粗鬆症の相互関係―The ROAD study 2nd visit (2015)
  • Author(s): 吉村典子、村木重之、岡敬之、田中栄、川口浩、中村耕三、阿久根徹
  • Organizer: 第33回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル（新宿区）
  • Year and Date: 2015-07-23
• [Presentation] 本邦における変形性股関節症の有病率―The ROAD study― (2015)
  • Author(s): 飯高世子、村木重之、岡敬之、田中栄、川口浩、中村耕三、阿久根徹、吉村典子
  • Organizer: 第27回日本運動器科学会
  • Place of Presentation: 宮崎観光ホテル（宮崎市）
  • Year and Date: 2015-07-04
• [Presentation] ロコモ度テストと要介護予測指標との関連：ROADスタディ第3回目疫学調査より (2015)
  • Author(s): 阿久根徹、村木重之、緒方徹、田中栄、中村耕三、吉村典子
  • Organizer: 第52回日本リハビリテーション医学会学術集会
  • Place of Presentation: 朱鷺メッセ（新潟市）
  • Year and Date: 2015-05-28
• [Presentation] 手指の変形性関節症と関連因子の検討―The ROAD study― (2015)
  • Author(s): 児玉理恵、岡敬之、村木重之、田中栄、川口浩、中村耕三、阿久根徹、吉村典子
  • Organizer: 第88回日本整形外科学会学術総会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2015-05-21
• [Presentation] 要介護三大原因の因果関係の検討：ロコモとメタボと認知症―ROADスタディ3年後の追跡― (2014)
  • Author(s): 吉村典子、村木重之、岡敬之、田中栄、川口浩、中村耕三、阿久根徹
  • Organizer: 第16回日本骨粗鬆症学会
  • Place of Presentation: 東京京王プラザホテル（新宿区）
  • Year and Date: 2014-10-23 – 2014-10-25
• [Presentation] 変形性膝関節症における骨棘形成の臨床的意義―ROADスタディ3年追跡調査― (2014)
  • Author(s): 村木重之、阿久根徹、田中栄、岡敬之、川口浩、中村耕三、吉村典子
  • Organizer: 第16回日本骨粗鬆症学会
  • Place of Presentation: 東京京王プラザホテル（新宿区）
  • Year and Date: 2014-10-23 – 2014-10-25
• [Presentation] 手指の変形性関節症の有病率と関連因子の検討―The ROAD study― (2014)
  • Author(s): 児玉理恵、岡敬之、村木重之、田中栄、中村耕三、阿久根徹、吉村典子
  • Organizer: 第16回日本骨粗鬆症学会
  • Place of Presentation: 東京京王プラザホテル（新宿区）
  • Year and Date: 2014-10-23 – 2014-10-25
• [Presentation] サルコペニアは膝痛・腰痛と関連し、中年期運動習慣は老年期サルコペニア有病率の低値と関連する The ROAD Study (2014)
  • Author(s): 阿久根 徹, 村木 重之, 岡 敬之, 田中 栄, 川口 浩, 中村 耕三, 吉村 典子
  • Organizer: 第87回日本整形外科学会学術総会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2014-05-22 – 2014-05-25
• [Presentation] 中高年一般住民集団の腰椎X線計測指標における腰痛関連因子の解明 The ROAD Study (2014)
  • Author(s): 阿久根 徹, 岡 敬之, 村木 重之, 田中 栄, 川口 浩, 中村 耕三, 吉村 典子
  • Organizer: 第87回日本整形外科学会学術総会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2014-05-22 – 2014-05-25
• [Presentation] 変形性膝関節症の疼痛およびADL障害への影響 ROAD追跡調査より (2014)
  • Author(s): 村木 重之, 阿久根 徹, 岡 敬之, 田中 栄, 川口 浩, 中村 耕三, 吉村 典子
  • Organizer: 第87回日本整形外科学会学術総会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2014-05-22 – 2014-05-25
• [Presentation] 運動機能関連項目における要介護移行リスクおよび高リスク者ピックアップツールの検討 The ROAD Study (2014)
  • Author(s): 阿久根 徹, 村木 重之, 岡 敬之, 田中 栄, 川口 浩, 中村 耕三, 吉村 典子
  • Organizer: 第87回日本整形外科学会学術総会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2014-05-22 – 2014-05-25
• [Presentation] 変形性膝関節症および筋力・運動能力低下は要介護移行リスクを増大させる：The ROAD study. (2013)
  • Author(s): 17. 阿久根徹、村木重之、岡敬之、田中栄、川口浩、中村耕三、吉村典子
  • Organizer: 第25回日本運動器科学会
  • Place of Presentation: 神戸市（神戸国際会議場）
• [Presentation] ロコモ5に準じた5項目評価法は要介護移行予測ツールとして有用である：The ROAD study. (2013)
  • Author(s): 18. 阿久根徹、村木重之、岡敬之、田中栄、川口浩、中村耕三、吉村典子
  • Organizer: 第25回日本運動器科学会
  • Place of Presentation: 神戸市（神戸国際会議場）
• [Presentation] サルコペニアの有病率の解明および運動機能・中年期運動習慣との関連―The ROAD study (2013)
  • Author(s): 20. 阿久根徹、村木重之、岡敬之、田中栄、川口浩、中村耕三、吉村典子
  • Organizer: 第15回日本骨粗鬆症学会
  • Place of Presentation: 大阪市（大阪国際会議場）
• [Presentation] 変形性膝関節症および筋力・運動能力低下は要介護のリスクである―The ROAD study (2013)
  • Author(s): 20. 阿久根徹、村木重之、岡敬之、田中栄、川口浩、中村耕三、吉村典子
  • Organizer: 第15回日本骨粗鬆症学会
  • Place of Presentation: 大阪市（大阪国際会議場）
• [Remarks] 平成26年度 月例報告
  • URL: http://www.rehab.go.jp/monthly/2014_7.html
• [Remarks] 平成26年度 月例報告
  • URL: http://www.rehab.go.jp/monthly/2014_9.html