Development of new preventive methods for allergy and obesity using of the analysis on intestinal flora microbiome
Project/Area Number |
25670295
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Kanazawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KAMBAYASHI Yasuhiro 金沢大学, 医学系, 講師 (20345630)
FUKUTOMI Yuma 独立行政法人国立病院機構(相模原病院臨床研究センター), 診断・治療薬開発研究室, 室長 (30463110)
人見 嘉哲 金沢大学, 医学系, 准教授 (70231545)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | アレルギー / 小児 / 腸内細菌 / 気管支喘息 / 食事 / 肥満 / マイクロバイオーム / メタゲノム |
Outline of Final Research Achievements |
The combination of allergic diseases such as asthma and obesity or overweight are considered to be produced by the eating habits. We have performed 3 years follow-up study on infants aged 3-5 years from 2013 and analyzed the strain of intestinal flora and metagenome. Four infants disappeared asthma and 5 did not, and 4 still showed pollinosis. We have observed the differences in the pattern of the expressions of enterobacteriaceae together with the intake of carbohydrates among the three groups. There was a correlation between the pattern of the expressions of the bidfidobacteriu and the increase in weight of infants after comparing between the infants with and without the disappearance of asthma. These results suggest that inhibiting unnecessary intake of carbohydrates, subsequently suppressing the excess of weight gain lead to the disappearance of asthma in infants.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] A Longitudinal Study of Association between Heavy Metals and Itchy Eyes, Coughing in Chronic Cough Patients: Related with Non-Immunoglobulin E Mediated Mechanism2016
Author(s)
Thao Thi Thu Nguyen , Tomomi Higashi , Yasuhiro Kambayashi , Enoch Olando Anyenda , Yoshimasa Michigami , Johsuke Hara , Masaki Fujimura , Hiromasa Tsujiguchi , Masami Kitaoka , Hiroki Asakura , Daisuke Hori , Yuri Hibino, Tadashi Konoshita and Hiroyuki Nakamura
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Journal Title
Int. J. Environ. Res. Public Health
Volume: 13
Issue: 1
Pages: 110-123
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Usefulness of Electrocardiographic Voltage to Determine Myocardial Fibrosis in Hypertrophic Cardiomyopathy.2016
Author(s)
Konno T, Nagata Y, Teramoto R, Fujino N, Nomura A, Tada H, Sakata K, Furusho H, Takamura M, Nakamura H, Kawashiri MA, Yamagishi M, Hayashi K.
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Journal Title
Am J Cardiol.
Volume: 117
Issue: 3
Pages: 443-449
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prevalence of Chronic Pain, Especially Headache, and Relationship with Health-Related Quality of Life in Middle-Aged Japanese Residents.2016
Author(s)
Mitoma J, Kitaoka M, Asakura H, Anyenda EO, Hori D, Nguyen TT, Hamagishi T, Hayashi K, Suzuki F, Shimizu Y, Tsujiguchi H, Kambayashi Y, Hibino Y, Konoshita T, Sagara T, Shibata A, Nakamura H
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Journal Title
Health
Volume: 8
Issue: 01
Pages: 116-124
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The relationship between hypertension and health-related quality of life: adjusted by chronic pain, chronic diseases, and life habits in the general middle-aged population in Japan.2016
Author(s)
Kitaoka M, Mitoma J, Asakura H, Anyenda EO, Nguyen TT, Hamagishi T, Hori D, Suzuki F, Shibata A, Horii M, Tsujiguchi H, Hibino Y, Kambayashi Y, Hitomi Y, Shikura N, Nakamura H
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Journal Title
Environ Health Prev Med.
Volume: -
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A Genetic Variant in the Distal Enhancer Region of the Human Renin Gene Affects Renin Expression.2015
Author(s)
Makino Y, Konoshita T, Omori A, Maegawa N, Nakaya T, Ichikawa M, Yamamoto K, Wakahara S, Ishizuka T, Onoe T, Nakamura H; Genomic Disease Outcome Consortium (G-DOC) Study Investigators
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Journal Title
PLoS One.
Volume: 10(9)
Issue: 9
Pages: e0137469-e0137469
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Electrocardiographic QRS Fragmentation as a Marker for Myocardial Fibrosis in Hypertrophic Cardiomyopathy.2015
Author(s)
Konno T, Hayashi K, Fujino N, Oka R, Nomura A, Nagata Y, Hodatsu A, Sakata K, Furusho H, Takamura M, Nakamura H, Kawashiri MA, Yamagishi M.
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Journal Title
J Cardiovasc Electrophysiol.
Volume: 26
Issue: 10
Pages: 1081-1087
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Theobromine, the primary methylxanthine found in Theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclear factor-kappa B2014
Author(s)
Sugimoto N, Miwa S, Hitomi Y, Nakamura H, Tsuchiya H, Yachie A
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Journal Title
Nutr Cancer
Volume: 66(3)
Issue: 3
Pages: 419-23
DOI
Related Report
Peer Reviewed
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[Journal Article] Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline.2014
Author(s)
Noguchi-Shinohara M, Yuki S, Dohmoto C, Ikeda Y, Samuraki M, Iwasa K, Yokogawa M, Asai K, Komai K, Nakamura H, Yamada M.
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Journal Title
PLoS One
Volume: 14;9(5)
Issue: 5
Pages: e96013-e96013
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of Asian dust on daily cough occurrence in patients with chronic cough: A panel study.2014
Author(s)
Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakai S, Honda Y, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Anyenda EO, Hitomi Y, Nakamura H.
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Journal Title
Atmospheric Environment
Volume: 92
Pages: 506-513
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical impacts of albuminuria and glomerular filtration rate on renal, cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes.2014
Author(s)
Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H; The Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan
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Journal Title
Clin Exp Nephrol
Volume: -
Issue: 4
Pages: 613-620
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Erratum to: Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes.2014
Author(s)
Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H, The Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan.
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Journal Title
Clin Exp Nephrol
Volume: 18(4)
Issue: 4
Pages: 621-622
DOI
Related Report
Peer Reviewed
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[Journal Article] Long-term Heat Exposure Prevents Hypoxia-Induced Apoptosis in Mouse Fibroblast Cells2014
Author(s)
Sugimoto N, Shido O, Matsuzaki K, Katakura M, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
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Journal Title
Cell biochemistry and biophysics
Volume: (in press)
Issue: 1
Pages: 301-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Exacerbation of daily cough and allergic symptpms in adult patients with chronic cough by Asian dust: A hospital-based study in Kanazawa2014
Author(s)
Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakanishi S, Yoshizaki T, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Hitomi Y, and Nakamura H
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Journal Title
Atmospheric Environment
Volume: in press
Pages: 537-543
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Antipsychotics for delirium in the general hospital setting in consecutive 2453 inpatients : a prospective observational study2014
Author(s)
Hatta K, Kishi Y, Wada K, Odawara T, Takeuchi T, Shiganami T, Tsuchida K, Oshima Y, Uchimura N, Akaho R, Watanabe A, Taira T, Nishimura K, Hashimoto N, Usui C, Nakamura H
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Journal Title
Int J Geriatr Psychiatry
Volume: 29(3)
Issue: 3
Pages: 253-262
DOI
Related Report
Peer Reviewed
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[Journal Article] The possibility that requiring high-dose olanzapine cannot be explained by pharmacokinetics in the treatment of acute-phase schizophrenia2013
Author(s)
Hatta K, Takebayashi H, Sudo Y, Katayama S, Kasuya M, Shirai Y, Morikawa F, Nakase R, Nakamura M, Ito S, Kuga H, Nakamura M, Ohnuma T, Usui C, Nakamura H, Hirata T, Sawa Y, for the JAST study group
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Journal Title
Psychiatry Res
Volume: 210(2)
Issue: 2
Pages: 396-401
DOI
Related Report
Peer Reviewed
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[Journal Article] Vulnerability to traumatic stress in fibromyalgia patients : 19 months follow-up after the Great East Japan Disaster2013
Author(s)
Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Itoh K, Yamano Y, Nakamura H, Asukai N, Nakajima T, Nishioka K
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Journal Title
Arthritis Research & Therapy
Volume: 15(5)
Issue: 5
Pages: R130-R130
DOI
Related Report
Peer Reviewed
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[Journal Article] The Japanese version of the modified ACR preliminary diagnostic criteria for fibromyalgia and the fibromyalgia symptom scale : reliability and validity2013
Author(s)
Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Kanazawa T, Itoh K, Yamano Y, Nakamura H, Nakajima T, Nishioka K
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Journal Title
Mod Rheumatol
Volume: 23(5)
Issue: 5
Pages: 846-850
DOI
NAID
Related Report
Peer Reviewed
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