Evaluation of fish-related biomarkers in the impact on risk of coronary heart disease in the general population

• Project/Area Number: 25670298
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Osaka University
• Principal Investigator: Iso Hiroyasu 大阪大学, 医学(系)研究科(研究院), 教授 (50223053)
• Co-Investigator(Kenkyū-buntansha): Sawada Norie 国立研究開発法人国立がん研究センター, その他部局等, 室長 (00446551) ; Yamagishi Kazumasa 筑波大学, 医学医療系, 講師 (20375504)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 魚 / バイオマーカー / n-3系多価不飽和脂肪酸 / 重金属 / 虚血性心疾患 / コホート研究 / 予防医学 / 1

Outline of Final Research Achievements

The aim of this study was to examine the impact of fish-related biomarkers (plasma n-3 polyunsaturated fatty acids, mercury and cadmium) on risk of coronary heart disease in general population with intracohort case-control methods. An inverse association was observed between plasma eicosapenatenoic acid levels and risk of incident coronary heart disease. Stratified by plasma mercury and cadmium, the similar inverse trends were observed for each stratum. Though the conclusion was not definitive, our priory hypothesis that the preventive effect of fish on coronary heart disease would be weakened among persons with high plasma mercury or cadmium was not supported. In the Japanese general population, fish intake may be protective against risk of coronary heart disease regardless of mercury and cadmium levels.

Research Products

• [Journal Article] Is the association between healthy lifestyle behaviors and cardiovascular mortality modified by overweight status? The Japan Collaborative Cohort Study (2014)
  • Author(s): Eguchi E, Iso H, Tanabe N, Yatsuya H, Tamakoshi A; on behalf of the Japan Collaborative Cohort Study Group
  • Journal Title: Prev Med Volume: 62 Pages: 142-147
  • Peer Reviewed
• [Journal Article] Association between dietary behavior and risk of hypertension among Japanese male workers (2013)
  • Author(s): Umesawa M, Kitamura A, Kiyama M, Okada T, Shimizu Y, Imano H, Ohira T, Nakamura M, Maruyama K, Iso H
  • Journal Title: Hypertens Res Volume: 36(4) Pages: 374-80
  • Peer Reviewed
• [Journal Article] Dietary intake of saturated fatty acids and incident stroke and coronary heart disease in Japanese communities: the JPHC Study (2013)
  • Author(s): Yamagishi K, Iso H, Kokubo Y, Saito I, Yatsuya H, Ishihara J, Inoue M, Tsugane S; JPHC Study Group
  • Journal Title: Eur Heart J Volume: 34(16) Pages: 1225-32
  • NAID: 120007136192
  • Peer Reviewed
• [Journal Article] The impact of green tea and coffee consumption on the reduced risk of stroke incidence in Japanese population: the Japan public health center-based study cohort (2013)
  • Author(s): Kokubo Y, Iso H, Saito I, Yamagishi K, Yatsuya H, Ishihara J, Inoue M, Tsugane S.
  • Journal Title: Stroke Volume: 44(5) Pages: 1369-74
  • Peer Reviewed
• [Journal Article] Dietary patterns and risk of cardiovascular deaths among middle-aged Japanese: JACC Study (2013)
  • Author(s): Maruyama K, Iso H, Date C, Kikuchi S, Watanabe Y, Wada Y, Inaba Y, Tamakoshi A; JACC Study Group
  • Journal Title: Nutr Metab Cardiovasc Dis Volume: 23(6) Pages: 519-27
  • Peer Reviewed