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Evaluation of fish-related biomarkers in the impact on risk of coronary heart disease in the general population

Research Project

Project/Area Number 25670298
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Epidemiology and preventive medicine
Research InstitutionOsaka University

Principal Investigator

Iso Hiroyasu  大阪大学, 医学(系)研究科(研究院), 教授 (50223053)

Co-Investigator(Kenkyū-buntansha) Sawada Norie  国立研究開発法人国立がん研究センター, その他部局等, 室長 (00446551)
Yamagishi Kazumasa  筑波大学, 医学医療系, 講師 (20375504)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords魚 / バイオマーカー / n-3系多価不飽和脂肪酸 / 重金属 / 虚血性心疾患 / コホート研究 / 予防医学 / 1
Outline of Final Research Achievements

The aim of this study was to examine the impact of fish-related biomarkers (plasma n-3 polyunsaturated fatty acids, mercury and cadmium) on risk of coronary heart disease in general population with intracohort case-control methods. An inverse association was observed between plasma eicosapenatenoic acid levels and risk of incident coronary heart disease. Stratified by plasma mercury and cadmium, the similar inverse trends were observed for each stratum. Though the conclusion was not definitive, our priory hypothesis that the preventive effect of fish on coronary heart disease would be weakened among persons with high plasma mercury or cadmium was not supported. In the Japanese general population, fish intake may be protective against risk of coronary heart disease regardless of mercury and cadmium levels.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results)

  • [Journal Article] Is the association between healthy lifestyle behaviors and cardiovascular mortality modified by overweight status? The Japan Collaborative Cohort Study2014

    • Author(s)
      Eguchi E, Iso H, Tanabe N, Yatsuya H, Tamakoshi A; on behalf of the Japan Collaborative Cohort Study Group
    • Journal Title

      Prev Med

      Volume: 62 Pages: 142-147

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between dietary behavior and risk of hypertension among Japanese male workers2013

    • Author(s)
      Umesawa M, Kitamura A, Kiyama M, Okada T, Shimizu Y, Imano H, Ohira T, Nakamura M, Maruyama K, Iso H
    • Journal Title

      Hypertens Res

      Volume: 36(4) Pages: 374-80

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dietary intake of saturated fatty acids and incident stroke and coronary heart disease in Japanese communities: the JPHC Study2013

    • Author(s)
      Yamagishi K, Iso H, Kokubo Y, Saito I, Yatsuya H, Ishihara J, Inoue M, Tsugane S; JPHC Study Group
    • Journal Title

      Eur Heart J

      Volume: 34(16) Pages: 1225-32

    • NAID

      120007136192

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The impact of green tea and coffee consumption on the reduced risk of stroke incidence in Japanese population: the Japan public health center-based study cohort2013

    • Author(s)
      Kokubo Y, Iso H, Saito I, Yamagishi K, Yatsuya H, Ishihara J, Inoue M, Tsugane S.
    • Journal Title

      Stroke

      Volume: 44(5) Pages: 1369-74

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dietary patterns and risk of cardiovascular deaths among middle-aged Japanese: JACC Study2013

    • Author(s)
      Maruyama K, Iso H, Date C, Kikuchi S, Watanabe Y, Wada Y, Inaba Y, Tamakoshi A; JACC Study Group
    • Journal Title

      Nutr Metab Cardiovasc Dis

      Volume: 23(6) Pages: 519-27

    • Related Report
      2013 Research-status Report
    • Peer Reviewed

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Published: 2014-07-25   Modified: 2019-07-29  

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