| Project/Area Number |
25670303
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Kazutaka 慶應義塾大学, 政策・メディア研究科, 特任助教 (10466732)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMURA Tomonori 慶應義塾大学, 医学部, 教授 (00324567)
SOGA Tomoyoshi 慶應義塾大学, 環境情報学部, 教授 (60338217)
TOMITA Masaru 慶應義塾大学, 環境情報学部, 教授 (60227626)
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| Research Collaborator |
KURIHARA Ayako 慶應義塾大学, 医学部, 教授
HARADA Sei 慶應義塾大学, 医学部, 大学院生
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | メタボローム / 疫学 / バイオマーカー / 予防医学 / 運動 / 食事 / 飲酒 |
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| Research Abstract |
In this project, we developed metabolomics methodology for epidemiological setting both for CE-MS (polar) and LC-MS (lipids). In the statistical analysis, the association between health-related life style factors such as physical activity, alcohol drinking, diet intake and risk factors of non-communicable diseases including hepatopathy, hypertension, metabolic syndrome. As a result, various polar metabolites determined by CE-MS were determined with relation to alcohol drinking, hypertension, and physical activity. Branched-chain amino acids, leucine, isoleucine and valine, were significantly associated with degree of physical activity or clustering of metabolic syndrome. Further follow-up study is needed to elucidate whether these metabolites can be used for preventive biomarkers.
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