A novel epidemiological approach for primary prevention with metabolomics

• Project/Area Number: 25670303
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Epidemiology and preventive medicine
• Research Institution: Keio University
• Principal Investigator: TAKEBAYASHI Toru 慶應義塾大学, 医学部, 教授 (30265780)
• Co-Investigator(Kenkyū-buntansha): IKEDA Kazutaka 慶應義塾大学, 政策・メディア研究科, 特任助教 (10466732)
• Co-Investigator(Renkei-kenkyūsha): OKAMURA Tomonori 慶應義塾大学, 医学部, 教授 (00324567) ; SOGA Tomoyoshi 慶應義塾大学, 環境情報学部, 教授 (60338217) ; TOMITA Masaru 慶應義塾大学, 環境情報学部, 教授 (60227626)
• Research Collaborator: KURIHARA Ayako 慶應義塾大学, 医学部, 教授 ; HARADA Sei 慶應義塾大学, 医学部, 大学院生
• Project Period (FY): 2013-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: メタボローム / 疫学 / バイオマーカー / 予防医学 / 運動 / 食事 / 飲酒

Research Abstract

In this project, we developed metabolomics methodology for epidemiological setting both for CE-MS (polar) and LC-MS (lipids). In the statistical analysis, the association between health-related life style factors such as physical activity, alcohol drinking, diet intake and risk factors of non-communicable diseases including hepatopathy, hypertension, metabolic syndrome. As a result, various polar metabolites determined by CE-MS were determined with relation to alcohol drinking, hypertension, and physical activity. Branched-chain amino acids, leucine, isoleucine and valine, were significantly associated with degree of physical activity or clustering of metabolic syndrome. Further follow-up study is needed to elucidate whether these metabolites can be used for preventive biomarkers.

Research Products

• [Journal Article] メタボローム (2014)
  • Author(s): 武林亨
  • Journal Title: 動脈硬化予防 Volume: 12巻4号
• [Presentation] Accumulation of metabolic syndrome risk factors and plasma amino acids and their related metabolites : Tsuruoka Metabolomic Cohort Study (2014)
  • Author(s): Toru Takebayashi, Sei Harada, Ayako Kurihara, Miki Akiyama, Tomonori Okamura, Yuji Nishiwaki, Taichiro Tanaka, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita
  • Organizer: 10th Annual Meeting of Metabolomics Society
  • Place of Presentation: Tsuruoka
• [Presentation] Metabolomic profiling reveals novel biomarkers of alcohol-induced hypertension in community-dwelling men : Tsuruoka metabolomic study (2014)
  • Author(s): Sei Harada, Toru Takebayashi, Ayako Kurihara, Miki Akiyama, Daisuke Sugiyama, Kazuyo Kuwabara, Ayano Takeuchi, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita
  • Organizer: 10th Annual Meeting of Metabolomics Society
  • Place of Presentation: Tsuruoka
• [Presentation] Accumulation of metabolic syndrome risk factors and plasma amino acids and their related metabolites: Tsuruoka Metabolomic Cohort Study (2014)
  • Author(s): Takebayashi T
  • Organizer: 10th Annual Conference of Metabolomic Society
  • Place of Presentation: 鶴岡
• [Presentation] Metabolomic profiling reveals novel biomarkers of alcohol-induced hypertension in community-dwelling men: Tsuruoka metabolomic study (2014)
  • Author(s): Harada S
  • Organizer: 10th Annual Conference of Metabolomic Society
  • Place of Presentation: 鶴岡
• [Remarks]
  • URL: http://tsuruoka-mirai.net/
• [Remarks] 鶴岡みらい健康調査
  • URL: http://tsuruoka-mirai.net/