| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Inhalation exposure to fine particlate matters induces chronic inflammation, leading to carcinogenesis and fibrosis in respiratory systems. We examined the mechanism of infllamatory responses caused by these materials by focusing on molecules that reside in endosomes and lysosomes. Multi-walled carbon nanotube induced inflammatory responses and DNA damage in lung prithelial cells via the release of the nuclear protein HMGB1 and DNA and the activation of Toll-like receptor 9 in lysosomes of naiboring cells. This is a new mechanism of carcinogenesis induced by multi-walled carbon nanotube. Carbon black and indium oxide nanoparticles induced inflammatory responses and DNA damage in cultured cells via a similar mechanism. In lung tissues of rats exposed to indium compounds, numerous inflammation- and lysosome-related genes were significantly upregulated.
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