Role of endosomes and lysosomes in inflammatory responses induced by fine particulate matters
| Project/Area Number |
25670313
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Mie University |
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Principal Investigator |
Hiraku Yusuke 三重大学, 医学(系)研究科(研究院), 講師 (30324510)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 粒子状物質 / エンドサイトーシス / リソソーム / 炎症 / 発がん / カーボンナノチューブ / HMGB１ / Toll-like receptor / HMGB1 / 石綿 / 繊維・粒子状物質 / 肺上皮細胞 |
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| Outline of Final Research Achievements |
Inhalation exposure to fine particlate matters induces chronic inflammation, leading to carcinogenesis and fibrosis in respiratory systems. We examined the mechanism of infllamatory responses caused by these materials by focusing on molecules that reside in endosomes and lysosomes. Multi-walled carbon nanotube induced inflammatory responses and DNA damage in lung prithelial cells via the release of the nuclear protein HMGB1 and DNA and the activation of Toll-like receptor 9 in lysosomes of naiboring cells. This is a new mechanism of carcinogenesis induced by multi-walled carbon nanotube. Carbon black and indium oxide nanoparticles induced inflammatory responses and DNA damage in cultured cells via a similar mechanism. In lung tissues of rats exposed to indium compounds, numerous inflammation- and lysosome-related genes were significantly upregulated.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Exposure assessment and heart rate variability monitoring in workers handling titanium dioxide particles-a pilot study.2016
Author(s)
Ichihara S, Li W, Omura S, Fujitani Y, Liu Y, Wang Q, Hiraku Y, Hisanaga N, Wakai K, Ding X, Kobayashi T, Ichihara G.
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Journal Title
J. Nanopart. Res.
Volume: 18
Issue: 3
Pages: 52-52
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Inflammation-related DNA damage and expression of CD133 and Oct3/4 in cholangiocarcinoma patients with poor prognosis2013
Author(s)
Thanan R, Pairojkul C, Pinlaor S, Khuntikeo N, Wongkham C, Sripa B, Ma N, Vaeteewoottacharn K, Furukawa A, Kobayashi H, Hiraku Y, Oikawa S, Kawanishi S, Yongvanit P, Murata M
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Journal Title
Free Radic Biol Med
Volume: 65
Pages: 1464-1472
DOI
Related Report
Peer Reviewed
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[Presentation] Inflammation-related DNA damage in relation to the expression of cancer stemness markers in human nasopharyngeal carcinoma2015
Author(s)
Wang S, Ma N, Kawanishi S, Zhao W, Midorikawa K, Hiraku Y, Oikawa S, Zhang Z, Huang G, Murata M
Organizer
SFRR-E/SNFS Meeting Stuttgart 2015: Redox Biology Meets Nutrition
Place of Presentation
University of Hohenheim, Stuttgart, Germany
Year and Date
2015-09-01
Related Report
Int'l Joint Research
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