Effect of infertility treatment on pregnancy associated complications and child development.

• Project/Area Number: 25670314
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Teikyo University
• Principal Investigator: Ohkubo Takayoshi 帝京大学, 医学部, 教授 (60344652)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 母子保健 / 不妊治療 / 胎児

Outline of Final Research Achievements

In a total of 544 nulliparous pregnant women with normal blood pressure at entry who participated in the Babies and Their Parents’ Longitudinal Observation in Suzuki Memorial Hospital in the Intrauterine Period (BOSHI) Study, home diastolic blood pressure value just before delivery was significantly higher in women with a experience of infertility treatment than those without the experience of the treatment. No significant difference was observed according to the experience of infertility treatment in infant’s gestational week, sex, height, head and chest circumferences and apgar scores.

Research Products

• [Journal Article] Maternal clinic and home blood pressure measurements during pregnancy and infant birth weight: the BOSHI study. (2016)
  • Author(s): 5.Iwama N, Metoki H, Ohkubo T, Ishikuro M, Obara T, Kikuya M, Yagihashi K, Nishigori H, Sugiyama T, Sugawara J, Yaegashi N, Hoshi K, Suzuki M, Kuriyama S, Imai Y; BOSHI Study Group
  • Journal Title: Hypertens Res. Volume: 39 Issue: 3 Pages: 151-157
  • DOI: 10.1038/hr.2015.108
  • Peer Reviewed
• [Journal Article] Reference values and associated factors for Japanese newborns' blood pressure and pulse rate: the babies' and their parents' longitudinal observation in Suzuki Memorial Hospital on intrauterine period (BOSHI) study. (2016)
  • Author(s): Satoh M, Inoue R, Tada H, Hosaka M, Metoki H, Asayama K, Murakami T, Mano N, Ohkubo T, Yagihashi K, Hoshi K, Suzuki M, Imai Y.
  • Journal Title: J Hypertens. Volume: 34 Issue: 8 Pages: 1578-1585
  • DOI: 10.1097/hjh.0000000000000976
  • Peer Reviewed
• [Journal Article] Parity as a factor affecting the white-coat effect in pregnant women: the BOSHI study. (2015)
  • Author(s): Ishikuro M, Obara T, Metoki H, Ohkubo T, Iwama N, Katagiri M, Nishigori H, Narikawa Y, Yagihashi K, Kikuya M, Yaegashi N, Hoshi K, Suzuki M, Kuriyama S, Imai Y.
  • Journal Title: Hypertens Res. Volume: 38 Issue: 11 Pages: 770-775
  • DOI: 10.1038/hr.2015.97
  • Peer Reviewed
• [Journal Article] Differences between clinic and home blood pressure measurements during pregnancy. (2015)
  • Author(s): Ishikuro M, Obara T, Metoki H, Ohkubo T, Kikuya M, Yaegashi N, Kuriyama S, Imai Y.
  • Journal Title: J Hypertens. Volume: 33 Issue: 7 Pages: 1492-1493
  • DOI: 10.1097/hjh.0000000000000608
  • Peer Reviewed
• [Presentation] 不妊症既往と妊娠中の血圧との関連 (2015)
  • Author(s): 石黒真美、小原拓、目時弘仁、菊谷昌浩、栗山進一、大久保孝義、今井潤
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: ひめぎんホール（愛媛県松山市）
  • Year and Date: 2015-10-11
• [Presentation] 妊婦における尿中塩分排泄量と塩分・栄養診断システム算出の塩分摂取量の相関 (2014)
  • Author(s): 佐藤倫広、丹野由美、保坂実樹、目時弘仁、小原拓、浅山敬、眞野成康、星和彦、鈴木雅洲、今井潤
  • Organizer: 第37回日本高血圧学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-10-19
• [Presentation] Out-of-office blood pressure monitoring during pregnancy (2014)
  • Author(s): Hirohito Metoki, Takayoshi Ohkubo, Noriyuki Iwama, Mami Ishikuro, Taku Obara, Hidekazu Nishigori, Takashi Sugiyama, Junichi Sugawara, Shinichi Kuriyama, Kazuhiko Hoshi, Masakuni Suzuki, Nobuo Yaegashi, Yutaka Imai
  • Organizer: The 35th Meeting of Japan Society for the Study of Hypertension in Pregnancy
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-09-19