| Project/Area Number |
25670321
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MASUDA Mitsuharu 京都府立医科大学, 医学(系)研究科(研究院), 博士研究員 (10305568)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIKAWA Hideki 京都府立医科大学, 医学研究科, 特任教授 (30351795)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌予防 / 大腸癌 / 天然物 / ジュース / 複合成分 |
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| Outline of Final Research Achievements |
We evaluated the effects of a variety of natural fruit juices on inhibitory activity of cellular proliferation by reactivating RB function and anti-inflammatory ability based on the concept of “molecular-targeting cancer prevention” to prevent colon cancer.
As the results, a part of fruit juices showed growth-inhibitory activity by G1-phase arrest with reactivation of RB protein. Moreover, several juices also showed anti-inflammatory effects. However, most of juices did not show these effects. We would like to find the more ideal juices for “molecular-targeting cancer prevention”.
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