| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Because multiple chemicals exist in the workplace environment, the risk assessments for workers are needed to consider co-exposures to multiple chemicals. However, the risk assessments are generally handled on a chemical-by-chemical basis; the risk assessments based on multiple exposures to chemicals have yet to be established. This study was aimed to evaluate the risk for cancer incidence among workers exposed to multiple chemicals by using historical cohort study, nested case-control study, and meta-analysis. The results of this study suggest the following. 1. Carcinogenic chemicals had the potential to cause cancer at site other than established target organ, but multiple exposures to carcinogenic chemicals had neither additive effect nor synergistic effect. 2. Workers without exposure to carcinogenic chemicals did not have an increased risk for cancer incidence associated with multiple exposures to chemicals in workplace.
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