• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Historical cohort study on cancer risk among workers with combined exposure to multiple chemicals

Research Project

Project/Area Number 25670323
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Research InstitutionNara Medical University

Principal Investigator

Tomioka Kimiko  奈良県立医科大学, 医学部, 特任准教授 (20393259)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords産業保健 / 疫学 / 化学物質 / リスク・アセスメント / 発癌リスク / 発がんリスク / 複合曝露 / 職業性曝露
Outline of Final Research Achievements

Because multiple chemicals exist in the workplace environment, the risk assessments for workers are needed to consider co-exposures to multiple chemicals. However, the risk assessments are generally handled on a chemical-by-chemical basis; the risk assessments based on multiple exposures to chemicals have yet to be established. This study was aimed to evaluate the risk for cancer incidence among workers exposed to multiple chemicals by using historical cohort study, nested case-control study, and meta-analysis. The results of this study suggest the following. 1. Carcinogenic chemicals had the potential to cause cancer at site other than established target organ, but multiple exposures to carcinogenic chemicals had neither additive effect nor synergistic effect. 2. Workers without exposure to carcinogenic chemicals did not have an increased risk for cancer incidence associated with multiple exposures to chemicals in workplace.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (3 results)

  • [Journal Article] Risk of Lung Cancer in Workers Exposed to Benzidine and/or Beta-Naphthylamine: A Systematic Review and Meta-Analysis2016

    • Author(s)
      Kimiko Tomioka, Keigo Saeki, Kenji Obayashi, Norio Kurumatani.
    • Journal Title

      Journal of Epidemiology

      Volume: 26 Issue: 9 Pages: 447-458

    • DOI

      10.2188/jea.JE20150233

    • NAID

      130005409017

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Increased risk of lung cancer associated with occupational exposure to benzidine and/or beta-naphthylamine.2015

    • Author(s)
      Tomioka K, Obayashi K, Saeki K, Okamoto N, Kurumatani N.
    • Journal Title

      International archives of occupational and environmental health

      Volume: 88 Issue: 4 Pages: 455-65

    • DOI

      10.1007/s00420-014-0974-1

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Risk for lung cancer in workers exposed to benzidine and/or beta-naphthylamine: a protocol for systematic review and meta-analysis.2014

    • Author(s)
      Tomioka K, Saeki K, Obayashi K, Tanaka Y, Kurumatani N.
    • Journal Title

      Systematic reviews

      Volume: 3 Issue: 1 Pages: 112-112

    • DOI

      10.1186/2046-4053-3-112

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Lung cancer risk in workers exposed to benzidine and/or beta-naphthylamine: a systematic review and meta-analysis2016

    • Author(s)
      Kimiko Tomioka, Keigo Saeki, Kenji Obayashi, and Norio Kurumatani
    • Organizer
      第26回日本疫学会学術総会
    • Place of Presentation
      米子コンベンションセンター
    • Year and Date
      2016-01-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 芳香族アミン曝露作業者の肝臓癌リスク―メタ・アナリシスによる検討―2016

    • Author(s)
      冨岡公子、毛利一平、中村賢治
    • Organizer
      第56回近畿産業衛生学会
    • Place of Presentation
      ピアザ淡海(滋賀県大津市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 芳香族アミン曝露作業者の複合曝露による発癌リスク2013

    • Author(s)
      冨岡公子、大林賢史、佐伯圭吾、岡本 希、車谷典男
    • Organizer
      第53回近畿産業衛生学会
    • Place of Presentation
      京都大学医学部
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi