Application of a non-invasive assessment method for lumbar spine trabecular bone microarchitecture to the Japanese population: its validity in vertebral fracture risk assessment

• Project/Area Number: 25670326
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Kinki University
• Principal Investigator: IKI Masayuki 近畿大学, 医学部, 教授 (50184388)
• Co-Investigator(Kenkyū-buntansha): TAMAKI Junko 大阪医科大学, 医学部, 教授 (90326356) ; SATO Yuho 仁愛大学, 人間生活学部, 教授 (10337115) ; MOON Jong-Song 畿央大学, 健康科学部, 准教授 (50460960)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 骨粗鬆症 / 椎体骨折 / Trabecular bone score / 海綿骨微細構造 / リスク評価 / 骨密度 / 骨微細構造指標 / trabecular bone score / 骨折リスク評価

Outline of Final Research Achievements

We examined whether or not trabecular bone score (TBS) predicts the risk of incident vertebral fracture in community dwelling 890 women and 855 men. Prediction accuracy of TBS represented by area under ROC curve was 0.682 and 0.630 for women and men, respectively, which were significantly better than chance, but was not sufficient enough to use in clinical settings. The follow-up period was short in men and should be extended so as to be analyzed with a greater statistical power. In addition, prediction models incorporating risk factors other than TBS and bone density should be developed to improve their validity.

Research Products

• [Journal Article] Trabecular bone score may improve FRAX prediction accuracy for major osteoporotic fractures in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in men (FORMEN) Study. (2015)
  • Author(s): Iki M, Fujita Y, Tamaki J, Kouda K, Yura A, Sato Y, Moon JS, Winzenrieth R, Okamoto N, Kurumatani N.
  • Journal Title: Osteoporos Int Volume: 印刷中 Issue: 6 Pages: 1841-1848
  • DOI: 10.1007/s00198-015-3092-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Age-related normative values of trabecular bone score (TBS) for Japanese women: the Japanese Population-based Osteoporosis (JPOS) study (2015)
  • Author(s): Iki M, Tamaki J, Sato Y, Winzenrieth R, Kagamimori S, Kagawa Y, Yoneshima H
  • Journal Title: Osteoporos Int. Volume: 26 Issue: 1 Pages: 245-52
  • DOI: 10.1007/s00198-014-2856-5
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Trabecular bone score (TBS) predicts vertebral fractures in Japanese women over 10 years independently of bone density and prevalent vertebral deformity : the Japanese Population-Based Osteoporosis (JPOS) cohort study (2014)
  • Author(s): Iki M, Tamaki J, Kadowaki E, Sato Y, Dongmei N, Winzenrieth R, Kagamimori S, Kagawa Y, Yoneshima H
  • Journal Title: Journal of Bone and Mineral Research Volume: 29 Issue: 2 Pages: 399-407
  • DOI: 10.1002/jbmr.2048
  • Peer Reviewed
• [Presentation] Trabecular Bone Score Improves Prediction accuracy of FRAX for Major Osteoporotic Fractures in Elderly Japanese Men: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study (2014)
  • Author(s): Iki M, Fujita Y, Tamaki J, Sato Y, Winzenrieth R, Kouda K, Yura A, Moon JS, Okamoto N, Kurumatani N
  • Organizer: American Society of Bone and Mineral Research Annual Meeting 2014
  • Place of Presentation: Houston, Texas, USA
  • Year and Date: 2014-09-12 – 2014-09-15
• [Presentation] Dose Trabecular Bone Score (TBS) Improve the Predictive Ability of FRAX ? : The Japanese Population-based Osteoporosis (JPOS) Cohort Study (2014)
  • Author(s): Tamaki J, Iki M, Sato Y, Winzenrieth R, Kajita E, Kagamimori S, Kagawa Y, Yoneshima H for JPOS Study Group
  • Organizer: American Society of Bone and Mineral Research Annual Meeting 2014
  • Place of Presentation: Houston, Texas, USA
  • Year and Date: 2014-09-12 – 2014-09-15
• [Presentation] 日本人女性における海綿骨微細構造指標Trabecular bone score (TBS) の標準値とその国際比較 (2014)
  • Author(s): 伊木雅之、玉置淳子、佐藤裕保、Renaud Winzenrieth、鏡森定信、香川芳子、米島秀夫
  • Organizer: 第32回日本骨代謝学会
  • Place of Presentation: 大阪(大阪国際会議場)
  • Year and Date: 2014-07-23 – 2014-07-26
• [Presentation] 日本人女性における海綿骨微細構造指標Trabecular bone score (TBS) の標準値 (2014)
  • Author(s): 伊木雅之、玉置淳子、佐藤裕保、Renaud Winzenrieth、鏡森定信、香川芳子、米島秀夫
  • Organizer: 第34回日本骨形態計測学会
  • Place of Presentation: 札幌(さっぽろ芸文館)
  • Year and Date: 2014-06-12 – 2014-06-14
• [Remarks] JPOS研究（The JPOS Study）
• [Remarks] The JPOS Study
  • URL: http://www.med.kindai.ac.jp/pubheal/jpos/index.html