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Determinants of endotoxin levels in suspended particles and their associations with asthma

Research Project

Project/Area Number 25670327
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Research InstitutionHyogo Medical University

Principal Investigator

Shima Masayuki  兵庫医科大学, 医学部, 教授 (40226197)

Co-Investigator(Kenkyū-buntansha) OTANI Naruhito  兵庫医科大学, 医学部, 助教 (10561772)
Research Collaborator YODA Yoshiko  兵庫医科大学, 医学部, 助教 (80748434)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsエンドトキシン / 微小粒子状物質 / 粗大粒子 / 喘息 / アレルギー / 生活環境 / 空気清浄機 / ペット / 浮遊粒子
Outline of Final Research Achievements

The endotoxin levels in indoor fine particles (PM2.5) and coarse particles (PM10-2.5) were correlated with the levels in outdoor respective particles. The levels were higher in higher in homes using tatami or carpet for floor than in homes of wooden flooring. The endotoxin levels in indoor PM2.5 were also higher in homes with pets, and lower in homes using air purifier.
The increase in endotoxin levels in PM2.5 and PM10-2.5 were associated with significant decrease in PEF and FEV1 among subjects with wheezing after exercise. On the other hand, among subjects without wheezing, no association between endotoxin levels and pulmonary function was observed.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] Association between traffic-related air pollution and asthma in preschool children in a national Japanese nested case-control study2016

    • Author(s)
      Hasunuma H, Sato T, Iwata T, Kohno Y, Nitta H, Odajima H, Ohara T, Omori T, Ono M, Yamazaki S, Shima M
    • Journal Title

      BMJ Open

      Volume: 6 Issue: 2 Pages: e010410-e010410

    • DOI

      10.1136/bmjopen-2015-010410

    • NAID

      120005822741

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interleukin-10 and interleukin-5 balance in patients with active asthma, those in remission, and healthy controls2015

    • Author(s)
      Tomiita M, Campos-Alberto E, Shima M, Namiki M, Sugimoto K, Kojima H, Watanabe H, Sekine K, Nishimuta T, Kohno Y, Shimojo N.
    • Journal Title

      Asia Pac Allergy

      Volume: 5 Issue: 4 Pages: 210-215

    • DOI

      10.5415/apallergy.2015.5.4.210

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Patterns of sensitization to inhalant allergens in Japanese lower-grade schoolchildren and related factors.2015

    • Author(s)
      Yamazaki S, Shima M, Nakadate T, Ohara T, Omori T, Ono M, Sato T, Nitta H
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 167 Issue: 4 Pages: 253-263

    • DOI

      10.1159/000439534

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 吸入アレルゲンの感作とアレルギー症状の発症・寛解2014

    • Author(s)
      島 正之
    • Journal Title

      喘息

      Volume: 27 Pages: 134-140

    • Related Report
      2014 Research-status Report
  • [Journal Article] 大気中微小粒子状物質(PM 2.5)の健康影響2014

    • Author(s)
      島 正之
    • Journal Title

      ビルと環境

      Volume: 144 Pages: 24-30

    • Related Report
      2013 Research-status Report
  • [Journal Article] 呼吸器系に対する微小粒子状物質(PM 2.5)の影響2013

    • Author(s)
      島 正之
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 667-672

    • Related Report
      2013 Research-status Report
  • [Presentation] 小学生のダニ・スギ特異lgEと関連要因2015

    • Author(s)
      島正之, 山崎新, 中館俊夫, 小野雅司, 大原利眞, 大森崇, 佐藤俊哉, 新田裕史
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] PM2.5の呼吸器系への影響に関する疫学研究2014

    • Author(s)
      島 正之
    • Organizer
      第23回日本臨床環境医学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2014-06-14 – 2014-06-15
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 大気汚染物質への個人暴露濃度が呼吸機能に与える急性影響2014

    • Author(s)
      余田 佳子, 櫻井 四郎, 大谷 成人, 島 正之
    • Organizer
      第84回日本衛生学会学術総会
    • Place of Presentation
      倉敷市
    • Year and Date
      2014-05-26 – 2014-05-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 大気汚染物質が喘息およびアレルギー症状を有する者の肺機能に与える急性影響2014

    • Author(s)
      余田 佳子, 高木 洋,若松 純子,大谷 成人,島 正之
    • Organizer
      第26回アレルギー学会春季臨床大会
    • Place of Presentation
      京都市
    • Year and Date
      2014-05-09 – 2014-05-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 大気中微小粒子状物質(PM 2.5)が健常者の気道炎症に与える影響

    • Author(s)
      余田 佳子、島 正之
    • Organizer
      第23回 日本健康医学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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