Determinants of endotoxin levels in suspended particles and their associations with asthma
| Project/Area Number |
25670327
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTANI Naruhito 兵庫医科大学, 医学部, 助教 (10561772)
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| Research Collaborator |
YODA Yoshiko 兵庫医科大学, 医学部, 助教 (80748434)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | エンドトキシン / 微小粒子状物質 / 粗大粒子 / 喘息 / アレルギー / 生活環境 / 空気清浄機 / ペット / 浮遊粒子 |
|---|
| Outline of Final Research Achievements |
The endotoxin levels in indoor fine particles (PM2.5) and coarse particles (PM10-2.5) were correlated with the levels in outdoor respective particles. The levels were higher in higher in homes using tatami or carpet for floor than in homes of wooden flooring. The endotoxin levels in indoor PM2.5 were also higher in homes with pets, and lower in homes using air purifier.
The increase in endotoxin levels in PM2.5 and PM10-2.5 were associated with significant decrease in PEF and FEV1 among subjects with wheezing after exercise. On the other hand, among subjects without wheezing, no association between endotoxin levels and pulmonary function was observed.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Association between traffic-related air pollution and asthma in preschool children in a national Japanese nested case-control study2016
Author(s)
Hasunuma H, Sato T, Iwata T, Kohno Y, Nitta H, Odajima H, Ohara T, Omori T, Ono M, Yamazaki S, Shima M
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Journal Title
BMJ Open
Volume: 6
Issue: 2
Pages: e010410-e010410
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interleukin-10 and interleukin-5 balance in patients with active asthma, those in remission, and healthy controls2015
Author(s)
Tomiita M, Campos-Alberto E, Shima M, Namiki M, Sugimoto K, Kojima H, Watanabe H, Sekine K, Nishimuta T, Kohno Y, Shimojo N.
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Journal Title
Asia Pac Allergy
Volume: 5
Issue: 4
Pages: 210-215
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 小学生のダニ・スギ特異lgEと関連要因2015
Author(s)
島正之, 山崎新, 中館俊夫, 小野雅司, 大原利眞, 大森崇, 佐藤俊哉, 新田裕史
Organizer
第64回日本アレルギー学会学術大会
Place of Presentation
グランドプリンスホテル新高輪（東京都）
Year and Date
2015-05-26
Related Report
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