Detection of novel interspersed repeat regions to differentiate among human populations in/near Japan and development of a method to estimate the populations
| Project/Area Number |
25670342
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAITOU Naruya 国立遺伝学研究所, 集団遺伝学系, 教授 (30192587)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 法医学 / 人類学 / 遺伝的異質性 / 反復配列 / 分散型 / Alu配列 / 縦列型 / STR / ヒト集団遺伝学 / ゲノム科学 / 繰り返し配列 |
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| Outline of Final Research Achievements |
In the present study, younger Alu Y family was focused on among some kind of interspersed Alu elements which have very high mutation rates to differentiate between genetically very close populations such as Japanese and Koreans. A transposon display method as the first step to detect novel interspersed repeat regions to differentiate among human populations in/near Japan and development was completed.
Alternatively, using more than 100 loci for short tandem repeats (STRs), a kind of tandem repeats, 2D dots for individuals by a factorial correspondence analysis revealed that Japanese and Korean populations could be categorized into two groups. When we calculated Bayes factors for these individuals based on Dirichlet multi-nominal distribution. Summary of those factors for two populations, showed about 92% of Japanese were strongly suggested as Japanese. More number of data for each population could be necessary to differentiate between both populations more accurately.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] CD109 attenuates TGF-β1 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells.2015
Author(s)
Jing-Min Zhang, Yoshiki Murakumo, Sumitaka Hagiwara, Ping Jiang, Shinji Mii, Emir Kalyoncu, Shoji Saito, Chikage Suzuki, Yasutaka Sakurai, Yoshiko Numata, Toshimichi Yamamoto, Masahide Takahashi
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 459
Issue: 2
Pages: 252-258
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Y-STR haplotype network analysis in Mongolian populations.2014
Author(s)
Toshimichi Yamamoto, Yuuji Hiroshige, Hisae Ogawa, Tomoki Senda, Daiki Horiba, Masayoshi Sakuma, Yuuka Kawaguchi, Yuuichi Kano, Kei Zaitsu, Takashi Yoshimoto, Akira Ishii
Organizer
9th International Symposium on Advances in Legal Medicine
Place of Presentation
福岡国際会議場（福岡県・福岡市）
Year and Date
2014-06-16 – 2014-06-20
Related Report
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