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Developing Animal Medel of Fraility to Reproduce the Symptoms of Human Fraility

Research Project

Project/Area Number 25670349
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionNagoya University

Principal Investigator

KUZUYA Masahumi  名古屋大学, 未来社会創造機構, 教授 (10283441)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords老化 / 虚弱 / 動物 / サルコぺニア / フレイル / サルコペニア
Outline of Final Research Achievements

The aim of this study is to develop animal model of frailty that reproduce the symptoms of human frailty. We used SAMP10 as a candidate of the human frailty model. Body weight (BW) of SAMP10 and control SAMR1 mice decreased after 28 weeks old and 36 weeks old, respectively. Compared with SAMR1 mice, spontaneous activity of SAMP10 was lower. Significant decline of grip strength or grip strength/BW was observed in SAMP10 after 28 weeks of age. Endurance capacity of SAMP10 decreased after 16 weeks of age. The significant decline of muscle weight of hindlimb was observed in SAMP10 at 64 weeks compared at 40 weeks of age, and muscle weigh of SAMP10 was significantly lower than those of SAMR1 at the same age. Compared with SAMR1, the levels of mRNA MuRF-1 mRNA were increased in soleus and gastrocnemius of SAMP10, whereas the levels of PGC-1α and IGF-1 mRNAs were decreased in soleus of SAMP10. These results may suggest that SAMP10 is useful model of human frailty.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (27 results)

All 2015 2014 2013

All Journal Article (19 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (8 results) (of which Invited: 2 results)

  • [Journal Article] 高齢者の介護予防・虚弱(フレイル)予防のための食の在り方2015

    • Author(s)
      葛谷雅文
    • Journal Title

      日本医師会雑誌

      Volume: 143(11)

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 特集 サルコペニアの基礎と臨床 序論2015

    • Author(s)
      葛谷雅文
    • Journal Title

      最新醫學

      Volume: 70(1) Pages: 5-6

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 特集 介護予防のカギはフレイル フレイルとは-その概念と定義を中心として2015

    • Author(s)
      葛谷雅文
    • Journal Title

      Aging&health

      Volume: 冬号No.72 23(4) Pages: 12-14

    • Related Report
      2014 Annual Research Report
  • [Journal Article] β-Hydroxy-β- methylbutyrate facilitates PI3K/Aktdependent mammalian target of rapamycin and FoxO1/3a phosphorylations and alleviates tumor necrosis factor α/ interferon γ-induced MuRF-1 expression in C2C12 cells2014

    • Author(s)
      Kimura K, Cheng XW, Inoue A, Hu L, Koike T, Kuzuya M
    • Journal Title

      Nutr Res

      Volume: 34(4) Issue: 4 Pages: 368-74

    • DOI

      10.1016/j.nutres.2014.02.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 特集 老年医学の視点から見た高齢者糖尿病 2高齢者糖尿病とサルコぺニア・フレイル2014

    • Author(s)
      佐竹昭介、葛谷雅文
    • Journal Title

      月刊糖尿病

      Volume: 6(11) Pages: 15-23

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 糖尿病とサルコペニア(総説)2014

    • Author(s)
      梅垣宏行、葛谷雅文
    • Journal Title

      Diabetes Journal: 糖尿病と代謝

      Volume: 42(3) Pages: 106-111

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 生活習慣病キーワード Glossaru of Topics サルコぺニアとNSTの役割2014

    • Author(s)
      葛谷雅文
    • Journal Title

      メディカル・ビューポイント

      Volume: 35(9) Pages: 6-6

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 高齢者におけるリハビリテーションの意義 第5回高齢者におけるリハビリテーションの阻害因子とそれに対する一般的対応 1.フレイル 4)フレイルの原因としての低栄養とその対策2014

    • Author(s)
      葛谷雅文
    • Journal Title

      Geriatric Medicine

      Volume: 52(8) Pages: 973-976

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 特集 サルコぺニアとフレイル 巻頭言2014

    • Author(s)
      葛谷雅文
    • Journal Title

      メディカル・ビューポイント

      Volume: 35(8) Pages: 1-1

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 特集/高齢者のフレイル(虚弱)とリハビリテーション 虚弱(フレイル)の原因としての低栄養とその対策2014

    • Author(s)
      葛谷雅文
    • Journal Title

      MB Med Reha

      Volume: 170 Pages: 126-130

    • Related Report
      2014 Annual Research Report
  • [Journal Article] バイオサイエンススコープ サルコぺニアと栄養2014

    • Author(s)
      葛谷雅文
    • Journal Title

      化学と生物

      Volume: 52(5) Pages: 328-330

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 今後の「食」を探る サルコぺニアの予防・改善2014

    • Author(s)
      葛谷雅文
    • Journal Title

      乳酸菌ニュース

      Volume: 484(2014春季号) Pages: 23-26

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 特集 肥満症の診療 update サルコぺニア肥満2014

    • Author(s)
      葛谷雅文
    • Journal Title

      日医雑誌

      Volume: 143(1) Pages: 72-72

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Cathepsin K-Mediated Notch1 Activation Contributes to Neovascularisation in Response to Hypoxia.2014

    • Author(s)
      Jiang H, Cheng XW, Shi GP, Hu L, Inoue A, Yamamura Y, Wu H, Takeshita K, Li X, Huang Z, Song H, Asai M, Hao CN, Unno K, Koike T, Oshida Y, Okumura K, Murohara T, Kuzuya M.
    • Journal Title

      Nature Communications.

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] β-Hydroxy-β-methylbutyrate facilitates PI3K/Akt-depednet mTOR and FoxO1/3 phosphorylations and alleviates TNF-1α/IFN-γ-induced MuRF expression in C2C12 Cells.2014

    • Author(s)
      Kimura K, Cheng XW, Inoue A, Hu L, Koike T ,Kuzuya M.
    • Journal Title

      Nutrition Research.

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes.2014

    • Author(s)
      Hayashi T, Kotani H, Yamaguchi T, Taguchi K, Iida M, Ina K, Maeda M, Kuzuya M, Hattori Y, Ignarro LJ.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111(3) Issue: 3 Pages: 1168-1173

    • DOI

      10.1073/pnas.1322153111

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cathepsin K activity controls injury-related vascular repair in mice.2014

    • Author(s)
      Hu L, Cheng XW, Song H, Inoue A, Jiang H, Li X, Shi GP, Kozawa E, Okumura K, Kuzuya M.
    • Journal Title

      Hypertension.

      Volume: 63(3) Issue: 3 Pages: 607-615

    • DOI

      10.1161/hypertensionaha.113.02141

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Circulating cathepsin K as a potential novel biomarker of coronary artery disease.2013

    • Author(s)
      Cheng XW, Kikuchi R, Ishii H, Yoshikawa D, Hu L, Takahashi R, Shibata R, Ikeda N, Kuzuya M, Okumura K, Murohara T.
    • Journal Title

      Atherosclerosis.

      Volume: 228(1) Issue: 1 Pages: 211-216

    • DOI

      10.1016/j.atherosclerosis.2013.01.004

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase-2 deficiency impairs aortic atherosclerotic calcification in ApoE-deficient mice.2013

    • Author(s)
      Sasaki T, Nakamura K, Sasada K, Okada S, Cheng XW, Suzuki T, Murohara T, Sato K, Kuzuya M.
    • Journal Title

      Atherosclerosis.

      Volume: 227(1) Issue: 1 Pages: 43-50

    • DOI

      10.1016/j.atherosclerosis.2012.12.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] シンポジウム8チーム医療でロコモ・サルコペニアを防ぐには 老年医学とサルコペニア・フレイル2015

    • Author(s)
      葛谷雅文
    • Organizer
      第18回日本病態栄養学会年次学術集会
    • Place of Presentation
      国立京都国際会館、京都市左京区
    • Year and Date
      2015-01-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] シンポジウム37 「サルコペニアと臨床薬理」超高齢社会におけるサルコペニアの重要性2014

    • Author(s)
      葛谷雅文
    • Organizer
      第35回日本臨床薬理学会学術集会
    • Place of Presentation
      ひめぎんホール 、愛媛県松山市
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 健常高齢者を基準としたサルコペニア診断基準の検討2014

    • Author(s)
      松下英二、伊藤ゆい、岡田希和子、佐竹昭介、葛谷雅文
    • Organizer
      第1回日本サルコペニア・フレイル研究会研究発表会
    • Place of Presentation
      伊藤国際学術研究センター、東京都文京区
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 運動介入が老化促進モデルマウスのサルコぺニアに及ぼす影響2014

    • Author(s)
      井上愛子、成憲武、黄哲、佐々木健、胡麗娜、姜海英、木村薫、小笠原真雄、葛谷雅文
    • Organizer
      第1回日本サルコペニア・フレイル研究会研究発表会
    • Place of Presentation
      伊藤国際学術研究センター、東京都文京区
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] C2C12 細胞におけるタンパク合成・分解に対する HMB の効果2014

    • Author(s)
      木村薫、成憲武、井上愛子、胡麗娜、小池晃彦、葛谷雅文
    • Organizer
      第1回日本サルコペニア・フレイル研究会研究発表会
    • Place of Presentation
      伊藤国際学術研究センター、東京都文京区
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Investigation of predictors of decreased skeketal muscle mass un community-dwelling elderly individuals.2014

    • Author(s)
      N Shiraishi, M Kuzuya,yY Suzuki, T Hirose, H Umegaki,K Okada, S Jeong
    • Organizer
      10th International Congress of the European Union Geriatric Medicine Society
    • Place of Presentation
      EU-GMS congress, Rotterdam, the Netherlands
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高齢者の歩行速度と高次機能障害の関係2014

    • Author(s)
      一柳知里、梅垣宏行、牧野多恵子、中嶋宏貴、野々垣禅、栁川まどか、葛谷雅文
    • Organizer
      第56回日本老年医学会学術集会
    • Place of Presentation
      福岡国際会議場、福岡県福岡市
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高齢者における「サルコペニア予備軍」と「非サルコペニア群」の運動機能の検討2014

    • Author(s)
      青山満喜、鈴木裕介、葛谷雅文
    • Organizer
      第56回日本老年医学会学術集会
    • Place of Presentation
      福岡国際会議場、福岡県福岡市
    • Year and Date
      2014-06-12
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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