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Metabolomic analysis for improvement of healthy lifespan

Research Project

Project/Area Number 25670350
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionKyoto University

Principal Investigator

Hiroshi Kondoh  京都大学, 医学(系)研究科(研究院), 助教 (80402890)

Co-Investigator(Kenkyū-buntansha) 横出 正之  京都大学, 医学(系)研究科(研究院), 教授 (20252447)
Co-Investigator(Renkei-kenkyūsha) Yanagida Mitsuhiro  沖縄科学技術大学大学院, 教授 (80025428)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords老化
Outline of Final Research Achievements

Metabolic analysis is utilized to detect metabolite profile quantatively and qualitatively, by using LC-MS. BY applying these techniques, We identified glucnoid forms of Reveratorol in skin absorbed condition (Plos One 2014) . Moreover we found the significant overlapping of metabolites between human blood and fission yeast(Mol Biosys 2014). Thus metabolmic approach is highly valuable tool to develop future diagnostic marker or therapuetic targets.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (23 results)

All 2015 2014 2013 Other

All Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 10 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Invited: 2 results) Book (2 results) Remarks (2 results)

  • [Journal Article] The Warburg-like regulation of PGAM in tumor.2015

    • Author(s)
      Taisuke Izumi, Takumi Mikawa, Hiroshi Kondoh, Matilde E LLeonart and Akifumi Takaori-Kondo.
    • Journal Title

      Trends in Cancer Research

      Volume: 10 Pages: 103-108

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.2015

    • Author(s)
      Goodson WH 3rd, 他合計173名。Hiroshi Kondohは59番目
    • Journal Title

      Carcinogenesis

      Volume: 36 Issue: Suppl 1 Pages: S254-S296

    • DOI

      10.1093/carcin/bgv039

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Disruptive chemicals, senescence and immortality.2015

    • Author(s)
      Amancio Carnero, Carmen Blanco-Aparicio , Hiroshi Kondoh , Matilde Lleonart , Juan Fernando Martinez-Leal , Chiara Mondello , A. Ivana Scovassi , John Pierce Wise Sr., Sandra S. Wise and Hemad Yasaey.
    • Journal Title

      Carcinogenesis

      Volume: 36 Issue: Suppl 1 Pages: S19-S37

    • DOI

      10.1093/carcin/bgv029

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dysregulated glycolysis as an oncogenic event.2015

    • Author(s)
      Takumi Mikawa, Matilde E LLeonart, Akifumi Takaori-Kondo, Nobuya Inagaki, Masayuki Yokode, and Hiroshi Kondoh
    • Journal Title

      Cell. Mol. Life Sci.

      Volume: 72 Issue: 10 Pages: 1881-92

    • DOI

      10.1007/s00018-015-1840-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Unexpected similarities between the Schizosaccharomyces and human blood metabolomes, and novel human metabolites2014

    • Author(s)
      Romanas Chaleckis, Masahiro Ebe, Tomáš Pluskal, Itsuo Murakami, Hiroshi Kondoh, and Mitsuhiro Yanagida
    • Journal Title

      Molecular BioSystems

      Volume: 10 Issue: 10 Pages: 2538-51

    • DOI

      10.1039/c4mb00346b

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Metabolism of skin-absorbed resveratrol into its glucuronized form in mouse skin.2014

    • Author(s)
      Itsuo Murakami, Romanas Chaleckis, Tomáš Pluskal, Ken Ito, Kousuke Hori, Masahiro Ebe, Mitsuhiro Yanagida and Hiroshi Kondoh.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 12 Pages: e115359-e115359

    • DOI

      10.1371/journal.pone.0115359

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm22014

    • Author(s)
      T Mikawa, T Maruyama, K Okamoto, H Nakagama, ME LLeonart, T Tsusaka, K Hori, I Murakami, T Izumi, A T-Kondo, M Yokode, G Peters, D Beach, & H Kondoh
    • Journal Title

      Journal of Cell Biology

      Volume: 204 Issue: 5 Pages: 729

    • DOI

      10.1083/jcb.201306149

    • NAID

      120005385888

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hepatocyte nuclear factor-1β promotes glucose uptake and glycolytic activity in ovarian clear carcinoma2013

    • Author(s)
      T Okamoto, M Mandai, N Matsumura, K Yamaguchi, H Kondoh, Y Amano, T Baba, J Hamanishi, K Abiko, K Kosaka, S K, Murphy, S Mori, I Konishi
    • Journal Title

      Molecular carcinogenesis

      Volume: Sep 17 Issue: 1 Pages: 1-15

    • DOI

      10.1002/mc.22072

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] miR-125b act as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-<alpha>, CCNJ, and MEGF92013

    • Author(s)
      A Feliciano; J Castellvi; A Artero-Castro; J A Leal; C Romagosa; J Hernández-Losa; V Peg; A Fabra; F Vidal; H Kondoh; S Ramón y Cajal; M E. Lleonart
    • Journal Title

      PLoS One

      Volume: 8(10) Issue: 10 Pages: e76247-e76247

    • DOI

      10.1371/journal.pone.0076247

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice2013

    • Author(s)
      Okuda, J., Niizuma, S., Shioi, T., Kato, T., Inuzuka, Y., Kawashima, T., Tamaki, Y., Kawamoto, A., Tanada, Y., Iwanaga, Y., Narazaki, M., Matsuda, T., Adachi, S., Soga, T., Takemura, G., Kondoh, H., Kita, T., Kimura, T.
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 8 Pages: e72173-e72173

    • DOI

      10.1371/journal.pone.0072173

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 老化の多様性を規定する代謝特性~進化におけるトレードオフ2015

    • Author(s)
      近藤祥司
    • Organizer
      第6回 癌・炎症と抗酸化研究会
    • Place of Presentation
      大分
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] ストレス老化シグナルに拮抗するワールブルグ解糖系転写後制御2015

    • Author(s)
      近藤祥司
    • Organizer
      第36回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] メタボロームアプローチによるヒト血液メタボライト解析2015

    • Author(s)
      近藤祥司
    • Organizer
      基礎老化学会
    • Place of Presentation
      横浜
    • Year and Date
      2015-06-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 老化はなぜ進むのか2015

    • Author(s)
      近藤祥司
    • Organizer
      第29回日本医学会総会
    • Place of Presentation
      京都
    • Year and Date
      2015-04-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Metabolomic approach for human blood2014

    • Author(s)
      近藤祥司
    • Organizer
      日本基礎老化学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-06-26 – 2014-06-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 高齢者の多様性を反映する代謝マーカーの血液メタボローム探索2014

    • Author(s)
      近藤祥司
    • Organizer
      第14回日本抗加齢医学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-06 – 2014-06-08
    • Related Report
      2014 Research-status Report
  • [Presentation] ストレス老化シグナルによる解糖系調節の誘導する生体防御バリアー形成

    • Author(s)
      近藤祥司
    • Organizer
      生化学若手の会
    • Place of Presentation
      大阪大学
    • Related Report
      2013 Research-status Report
  • [Presentation] ストレス老化シグナルによる解糖系調節の誘導する癌化バリアー形成

    • Author(s)
      近藤祥司
    • Organizer
      第一回癌と代謝研究会
    • Place of Presentation
      慶応大学山形キャンパス
    • Related Report
      2013 Research-status Report
  • [Presentation] マウスにおけるレスベラトロールの経皮吸収と代謝

    • Author(s)
      村上逸雄、Romanas Chaleckis、伊藤健、近藤祥司
    • Organizer
      老年医学会近畿地方会
    • Place of Presentation
      京都大学
    • Related Report
      2013 Research-status Report
  • [Book] シリーズ進化生物学の新潮流;老化という生存戦略;進化におけるトレードオフ2015

    • Author(s)
      近藤祥司
    • Total Pages
      222
    • Publisher
      日本評論社
    • Related Report
      2015 Annual Research Report
  • [Book] 老化生物学 老いと寿命のメカニズム2015

    • Author(s)
      近藤祥司
    • Total Pages
      390
    • Publisher
      MEDSI
    • Related Report
      2015 Annual Research Report
  • [Remarks] 近藤祥司ラボホームページ

    • URL

      http://www.anti-aging.jpn.com/

    • Related Report
      2015 Annual Research Report
  • [Remarks] http://www.anti-aging.jpn.com/research/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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