Autonomic nervous dysfunction as a risk factor for frailty: evaluation with standing load
Project/Area Number |
25670353
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
General internal medicine(including psychosomatic medicine)
|
Research Institution | National Hospital Organization, Ehime Medical Center (Clinical Research) (2015) Ehime University (2013-2014) |
Principal Investigator |
Kohara Katsuhiko 独立行政法人国立病院機構愛媛医療センター(臨床研究部), その他部局等, その他 (30260384)
|
Co-Investigator(Kenkyū-buntansha) |
OCHI MASAYUKI 愛媛大学, 医学部附属病院, 助教 (80648171)
NAGAI TOKIHISA 愛媛大学, 医学部総合医学教育センター, 講師 (90464370)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 自律神経機能 / フレイル / 起立負荷 / 重心動揺 / 転倒リスク / 起立性低血圧 / フレイルティ / 老年医学 / 動脈硬化 / 食後性低血圧 / 高齢者 |
Outline of Final Research Achievements |
Possible involvement of autonomic dysfunction in the frailty was investigated. Changes in autonomic nervous function were evaluated by power spectral analysis of heart rate in 288 participants in Anti-aging doc in Ehime University Hospital. Diastolic blood pressure was significantly increased after standing, while systolic BP was not. Low frequency power area (LF) (0.04-0.15Hz) was significantly increased (p<0.0001) after standing, while high frequency power area (HF) was significantly decreased (p<0.0001) 3 minutes after standing. Neither LF nor HF was associated with basal BP as well as BP after standing. Both LF and HF were significantly associated with age, one leg standing time and indices of body sway in standing position. These findings indicate autonomic dysfunction may associate to the frailty related to the fall.
|
Report
(4 results)
Research Products
(60 results)
-
-
-
-
-
-
-
[Journal Article] Association Between Genetic Variation in the <i>SCN10A</i> Gene and Cardiac Conduction Abnormalities in Patients With Hypertrophic Cardiomyopathy2015
Author(s)
Iio C, Ogimoto A, Nagai T, Suzuki J, Inoue K, Nishimura K, Uetani T, Okayama H, Okura T, Shigematsu Y, Tabara Y, Kohara K, Miki T, Hamada M, Higaki J.
-
Journal Title
International Heart Journal
Volume: 56
Issue: 4
Pages: 421-427
DOI
NAID
ISSN
1349-2365, 1349-3299
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Association of postural instability with asymptomatic cerebrovascular damage and cognitive decline: the Japan Shimanami Health Promoting Program study.2015
Author(s)
Tabara Y, Okada Y, Ohara M, Uetani E, Kido T, Ochi N, Nagai T, Igase M, Miki T, Matsuda F, Kohara K.
-
Journal Title
Stroke.
Volume: 46
Issue: 1
Pages: 16-22
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
[Journal Article] Postprandial hypotension as a risk marker for asymptomatic lacunar infarction.2014
Author(s)
Tabara Y, Okada Y, Uetani E, Nagai T, Igase M, Kido T, Ochi N, Ohara M, Takita R, Kohara K, Miki T.
-
Journal Title
J Hypertens
Volume: 32
Issue: 5
Pages: 1084-1090
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Genetic variation in CDH13 is associated with lower plasma adiponectin levels but greater adiponectin sensitivity in East Asian populations.2013
Author(s)
Gao H, Kim YM, Chen P, Igase M, Kawamoto R, Kim MK, Kohara K, Lee J, Miki T, Ong RT, Onuma H, Osawa H, Sim X, Teo YY, Tabara Y, Tai ES, van Dam RM.
-
Journal Title
Diabetes
Volume: 62
Issue: 12
Pages: 4277-4283
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Association of longer QT interval with arterial waveform and lower pulse pressure amplification: the Nagahama Study.2013
Author(s)
Tabara Y, Takahashi Y, Kohara K, Setoh K, Kawaguchi T, Terao C, Igase M, Yamada R, Kosugi S, Sekine A, Miki T, Nakayama T, Matsuda F; Nagahama Study Group.
-
Journal Title
Am J Hypertens
Volume: 26
Issue: 8
Pages: 973-980
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia.2013
Author(s)
Nakayama K, Ogawa A, Miyashita H, Tabara Y, Igase M, Kohara K, Miki T, Kagawa Y, Yanagisawa Y, Katashima M, Onda T, Okada K, Fukushima S, Iwamoto S
-
Journal Title
Hum Genet
Volume: 132
Issue: 2
Pages: 201-217
DOI
Related Report
Peer Reviewed
-
[Journal Article] Association of Chr17q25 with cerebral white matter hyperintensities and cognitive impairment: the J-SHIPP study2013
Author(s)
Tabara Y, Igase M, Okada Y, Nagai T, Uetani E, Kido T, Ochi N, Takita R, Yamamoto M, Kohara K, Miki T
-
Journal Title
Eur J Neurol
Volume: 20
Issue: 5
Pages: 860-882
DOI
Related Report
Peer Reviewed
-
[Journal Article] Association of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage: The J-SHIP Toon Health Study2012
Author(s)
Tabara Y, Igase M, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Okada Y, Hitsumoto S, Onuma H, Nagai T, Takata Y, Uetani E, Takita R, Kido T, Ochi N, Osawa H, Tanigawa T, Miki T
-
Journal Title
Clin Hemorheol Microcirc
Volume: in press
Issue: 3
Pages: 297-311
DOI
NAID
Related Report
Peer Reviewed
-
-
[Presentation] 血管不全と健康2016
Author(s)
小原克彦
Organizer
第1回日本血管不全学術集会
Place of Presentation
東京
Year and Date
2016-04-17
Related Report
Invited
-
-
-
[Presentation] 認知症合併高血圧2015
Author(s)
小原克彦
Organizer
第4回臨床高血圧フォーラム
Place of Presentation
福岡
Year and Date
2015-05-23
Related Report
Invited
-
[Presentation] 高血圧と認知症2015
Author(s)
小原克彦
Organizer
第56回日本神経学会
Place of Presentation
新潟
Year and Date
2015-05-20
Related Report
Invited
-
-
[Presentation] 高血圧と認知症2014
Author(s)
小原克彦
Organizer
第56回 日本老年医学会
Place of Presentation
福岡
Year and Date
2014-06-12 – 2014-06-14
Related Report
Invited
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-