Novel Therapy for CIPO

• Project/Area Number: 25670356
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Yokohama City University
• Principal Investigator: NAKAJIMA Atsushi 横浜市立大学, 医学(系)研究科(研究院), 教授 (30326037)
• Co-Investigator(Kenkyū-buntansha): WADA Koichiro 島根大学, 医学部, 教授 (90263467)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 希少難病 / 新規治療法 / 消化管難病 / 腸閉塞 / 消化器難病 / 希少疾患

Outline of Final Research Achievements

Chronic intestinal pseudo-obstructon (CIPO) is a rare severe digestive disease in which clinical symptoms of intestinal obstruction appear without any mechanical cause.
In this study we demonstrate the novel CIPO therapy utilizing percutaneous endoscopic gastrojejunostomy (PEG-J) tube which may be burdenless compared to conventional ileus tube.

Research Products

• [Journal Article] 慢性特発性偽性腸閉塞 (2014)
  • Author(s): 中島淳、冬木晶子、稲生優海、大久保秀則
  • Journal Title: 先端医学社 Volume: 23 Pages: 61-70
• [Journal Article] Oral choline tolerance test as a novel noninvasive method for predicting nonalcoholic steatohepatitis. (2014)
  • Author(s): Imajo K, Yoneda M, Fujita K, Kessoku T, Tomeno W, Ogawa Y, Shinohara Y, Sekino Y, Mawatari H, Nozaki Y, Kirikoshi H, Taguri M, Toshima G, Takahashi J, Saito S, Wada K, Nakajima A.
  • Journal Title: Journal of Gastroenterology Volume: 49 Issue: 2 Pages: 295-304
  • DOI: 10.1007/s00535-013-0776-3
  • Peer Reviewed
• [Journal Article] Assessment of small bowel motility in patients with chronic intestinal pseudo-obstruction using cine-MRI. (2013)
  • Author(s): Ohkubo H, Kessoku T, Fuyuki A, Iida H, Inamori M, Fujii T, Kawamura H, Hata Y, Nakajima A, Tkahara T
  • Journal Title: Am J Gastroenterol Volume: １０８ Issue: 7 Pages: 1130-9
  • DOI: 10.1038/ajg.2013.57
  • Peer Reviewed
• [Presentation] 慢性偽性腸閉塞症（CIPO）に対する新たな腸管減圧方法の提案 (2014)
  • Author(s): 大久保秀則、稲生優海、冬木晶子、稲森正彦、中島淳
  • Organizer: 第16回日本神経消化器病学会
  • Place of Presentation: 学術総合センター（東京都千代田区）
  • Year and Date: 2014-11-06